Fentanyl

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







40 Article(s)
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1 34877660 Effect of CYP3A5 and CYP3A4 Genetic Variants on Fentanyl Pharmacokinetics in a Pediatric Population. 2022 Apr 4
2 33298744 Intravenous Infusion of Fentanyl Has No Effect on Blood Concentration of Tacrolimus in Patients Receiving Hematopoietic Stem-Cell Transplantation. 2021 Oct 1 1
3 34045960 Development of a Virtual Chinese Pediatric Population Physiological Model Targeting Specific Metabolism and Kidney Elimination Pathways. 2021 1
4 34337735 Should we be concerned when COVID-19-positive patients take opioids to control their pain? Insights from a pharmacological point of view. 2021 Jul 2
5 31794512 Influence of St. John's Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial. 2020 Mar 2
6 30371861 Identification of Cytochrome P450 Polymorphisms in Burn Patients and Impact on Fentanyl Pharmacokinetics: A Pilot Study. 2019 Jan 1 1
7 31168770 Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children. 2019 Dec 1
8 31601999 Minor contribution of cytochrome P450 3A activity on fentanyl exposure in palliative care cancer patients. 2019 Oct 10 3
9 29363349 Drug metabolism in early infancy: opioids as an illustration. 2018 Mar 1
10 29601950 Association between MDR1/CYP3A4/OPRM1 gene polymorphisms and the post-caesarean fentanyl analgesic effect on Chinese women. 2018 Jun 30 5
11 30381583 Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy. 2018 Nov 20 2
12 28226339 Current Concepts of Phenylpiperidine Derivatives Use in the Treatment of Acute and Chronic Pain. 2017 Feb 3
13 25176283 Clinical pharmacology of fentanyl in preterm infants. A review. 2015 Jun 1
14 25651378 Pharmacokinetic interaction of intravenous fentanyl with ketoconazole. 2015 Jun 4
15 25948306 [Interindividual variation of pharmacokinetic disposition of and clinical responses to opioid analgesics in cancer pain patients]. 2015 1
16 26088794 CYP3A4 * 1G Genetic Polymorphism Influences Metabolism of Fentanyl in Human Liver Microsomes in Chinese Patients. 2015 5
17 24333052 Effect of ritonavir-induced cytochrome P450 3A4 inhibition on plasma fentanyl concentrations during patient-controlled epidural labor analgesia: a pharmacokinetic simulation. 2014 Feb 2
18 24469018 Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study. 2014 Apr 4
19 23257955 A simple liquid chromatography-tandem mass spectrometry method for determination of plasma fentanyl concentration in rats and patients with cancer pain. 2013 2
20 23313934 Effect of CYP3A4*18B polymorphisms and interactions with OPRM1 A118G on postoperative fentanyl requirements in patients undergoing radical gastrectomy. 2013 Mar 4
21 23557865 Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on postoperative fentanyl consumption in Korean gynecologic patients. 2013 May 1
22 24161162 Impact of CYP3A and ABCB1 polymorphisms on the pharmacokinetics and pharmacodynamics of fentanyl. 2013 Dec 1
23 21128989 Cytochrome P450 3A4 genetic polymorphisms and post-operative fentanyl requirements. 2012 Feb 2
24 21535061 Effect of CYP3A4*1G on the fentanyl consumption for intravenous patient-controlled analgesia after total abdominal hysterectomy in Chinese Han population. 2012 Apr 9
25 22764844 Population pharmacokinetics of transdermal fentanyl in patients with cancer-related pain. 2012 Jun 3
26 21223952 Impact of CYP3A4*1G polymorphism on metabolism of fentanyl in Chinese patients undergoing lower abdominal surgery. 2011 Apr 11 8
27 21513075 Influence of CYP3A5*3 polymorphism and interaction between CYP3A5*3 and CYP3A4*1G polymorphisms on post-operative fentanyl analgesia in Chinese patients undergoing gynaecological surgery. 2011 Apr 3
28 19784640 CYP3A4*1G genetic polymorphism influences CYP3A activity and response to fentanyl in Chinese gynecologic patients. 2010 Jan 7
29 17987285 Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl. 2008 Jan 2
30 16634729 Withdrawal symptoms from transdermal fentanyl (TDF) after an allogeneic peripheral blood stem cell transplant (PBSCT). 2006 Mar-Apr 1
31 16419387 Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases. 2005 Oct 2
32 12657846 Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil. 2003 Apr 1
33 12824820 Induction of CYP3A by ethanol in multiple in vitro and in vivo models. 2003 Jun 2
34 11811955 The paradoxical effect of acetaminophen on CYP3A4 activity and content in transfected HepG2 cells. 2002 Feb 1 1
35 10786743 The effect of paracetamol (acetaminophen) on fentanyl metabolism in vitro. 2000 May 3
36 10562786 Fentanyl inhibits metabolism of midazolam: competitive inhibition of CYP3A4 in vitro. 1999 Jun 3
37 9264313 Possible involvement of multiple cytochrome P450S in fentanyl and sufentanil metabolism as opposed to alfentanil. 1997 Jun 1 3
38 9311623 Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions. 1997 Sep 1
39 8712396 Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. 1996 Jan 6
40 8886601 Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4. 1996 Sep 3