Itraconazole

cytochrome P450 family 3 subfamily A member 4 ; Homo sapiens







165 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
51 26045286 Acute Invasive Pulmonary Aspergillosis Complicating Allergic Bronchopulmonary Aspergillosis: Case Report and Systematic Review. 2015 Oct 1
52 26184414 Effect of CYP3A5 and ABCB1 polymorphisms on the interaction between tacrolimus and itraconazole in patients with connective tissue disease. 2015 Sep 1
53 26736983 A semi-mechanistic pharmacokinetic model of saquinavir combined with itraconazole in HIV-1-positive patients. 2015 1
54 26736984 Pharmacokinetic model for the inhibition of simvastatin metabolism by itraconazole. 2015 1
55 24405193 Longitudinal monitoring of CYP3A activity in patients receiving 3 cycles of itraconazole pulse therapy for onychomycosis. 2014 Apr 4
56 24484539 Comparison of catalytic properties of cytochromes P450 3A4 and 3A5 by molecular docking simulation. 2014 2
57 25106415 Clinical CYP3A inhibitor alternatives to ketoconazole, clarithromycin and itraconazole, are not transported into the liver by hepatic organic anion transporting polypeptides and organic cation transporter 1. 2014 Nov 2
58 25216238 Liver injury associated with ketoconazole: review of the published evidence. 2014 Dec 1
59 25359648 Vitamin and mineral supplements: friend or foe when combined with medications? 2014 Nov 1
60 25429674 Drug interactions between nine antifungal agents and drugs metabolized by human cytochromes P450. 2014 4
61 23139378 Analysis of the repaglinide concentration increase produced by gemfibrozil and itraconazole based on the inhibition of the hepatic uptake transporter and metabolic enzymes. 2013 Feb 1
62 23462027 Colchicine-antimicrobial drug interactions: what pharmacists need to know in treating gout. 2013 Mar 1
63 24114622 Pharmacology of the new P2Y12 receptor inhibitors: insights on pharmacokinetic and pharmacodynamic properties. 2013 Oct 1
64 21838784 CYP2C8 but not CYP3A4 is important in the pharmacokinetics of montelukast. 2012 Feb 1
65 22106171 Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals. 2012 Mar 5
66 20400651 Itraconazole, a P-glycoprotein and CYP3A4 inhibitor, markedly raises the plasma concentrations and enhances the renin-inhibiting effect of aliskiren. 2011 Mar 1
67 21142269 Effect of inhibition of cytochrome P450 enzymes 2D6 and 3A4 on the pharmacokinetics of intravenous oxycodone: a randomized, three-phase, crossover, placebo-controlled study. 2011 1
68 21147222 Identification of permeability-related hurdles in oral delivery of curcumin using the Caco-2 cell model. 2011 Feb 1
69 21212239 Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants. 2011 Apr 3
70 21219398 4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans. 2011 Feb 1
71 21360715 Pharmacokinetic interactions between ciprofloxacin and itraconazole in healthy male volunteers. 2011 Apr 1
72 21410294 Pharmacokinetic drug interactions with vandetanib during coadministration with rifampicin or itraconazole. 2011 2
73 21490593 Evaluation of 6β-hydroxycortisol, 6β-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo. 2011 Jun 1
74 21716267 Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine. 2011 Aug 1
75 21771587 Drug interaction of (S)-warfarin, and not (R)-warfarin, with itraconazole in a hematopoietic stem cell transplant recipient. 2011 Oct 9 1
76 21832990 Identification of the rate-determining process in the hepatic clearance of atorvastatin in a clinical cassette microdosing study. 2011 Oct 1
77 20000889 Semi-mechanistic population pharmacokinetic drug-drug interaction modelling of a long half-life substrate and itraconazole. 2010 1
78 20076952 Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone. 2010 Apr 1
79 20497744 Pharmacokinetic modeling of the dosing interval dependency for the interaction between itraconazole and triazolam. 2010 Jun 2
80 20575631 Drug interaction between itraconazole and bortezomib: exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib. 2010 Jul 1
81 20642550 Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. 2010 Jul 1
82 20739919 Accurate prediction of dose-dependent CYP3A4 inhibition by itraconazole and its metabolites from in vitro inhibition data. 2010 Oct 4
83 19309762 Bioanalytical methods for the determination of itraconazole and hydroxyitraconazole: overview from clinical pharmacology, pharmacokinetic, pharmacodynamic and metabolism perspectives. 2009 Jul 1
84 19954708 4beta-hydroxycholesterol as a marker of CYP3A4 inhibition in vivo - effects of itraconazole in man. 2009 Dec 3
85 20230761 Subtype-selective GABA(A) receptor modulation yields a novel pharmacological profile: the design and development of TPA023. 2009 1
86 17495874 Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo. 2008 Jan 3
87 18218784 Effect of itraconazole on the pharmacokinetics of imidafenacin in healthy subjects. 2008 Mar 1
88 18520601 Effects of cyclosporine a on single-dose pharmacokinetics of intravenous itraconazole in patients with hematologic malignancies. 2008 Jun 1
89 18783297 General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information. 2008 1
90 19025521 Itraconazole, a potent inhibitor of P-glycoprotein, moderately increases plasma concentrations of oral morphine. 2008 Nov 1
91 19356088 Effects of cyclosporine A and itraconazole on permeability, biliary excretion and pharmacokinetics of amlodipine. 2008 Aug 2
92 17003527 Itraconazole comedication increases systemic levels of inhaled fluticasone in lung transplant recipients. 2007 1
93 17386084 Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models. 2007 Mar 26 1
94 17484517 Drug-drug interactions in the metabolism of imidafenacin: role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymes. 2007 Feb 1
95 17517842 Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescents. 2007 Aug 1
96 16418697 Effects of itraconazole and tandospirone on the pharmacokinetics of perospirone. 2006 Feb 2
97 16556082 Drug interactions during therapy with three major groups of antimicrobial agents. 2006 Apr 1
98 16700545 Surface plasmon resonance analysis of antifungal azoles binding to CYP3A4 with kinetic resolution of multiple binding orientations. 2006 May 23 4
99 17178259 Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance. 2006 Dec 1
100 15684493 Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. 2005 Feb 2