| 1 |
33263786 | Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells. | 2021 Mar |
1 |
| 2 |
34345857 | Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR. | 2021 |
1 |
| 3 |
31432507 | Long-term maintenance of functional primary human hepatocytes using small molecules. | 2020 Jan |
1 |
| 4 |
32788213 | Nuclear receptor phosphorylation in xenobiotic signal transduction. | 2020 Nov 6 |
2 |
| 5 |
33551819 | Transporter Gene Regulation in Sandwich Cultured Human Hepatocytes Through the Activation of Constitutive Androstane Receptor (CAR) or Aryl Hydrocarbon Receptor (AhR). | 2020 |
1 |
| 6 |
31168770 | Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children. | 2019 Dec |
1 |
| 7 |
31202736 | Indirect activation of constitutive androstane receptor in three-dimensionally cultured HepG2 cells. | 2019 Oct |
2 |
| 8 |
31256150 | Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia. | 2019 |
1 |
| 9 |
31270214 | Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver-Derived Cells by Attenuating Splicing. | 2019 Sep |
2 |
| 10 |
31436536 | Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor. | 2019 Sep |
2 |
| 11 |
29357810 | Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells. | 2018 |
3 |
| 12 |
29649093 | Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker. | 2018 Aug |
4 |
| 13 |
30581412 | Pharmacokinetic Interactions of Clinical Interest Between Direct Oral Anticoagulants and Antiepileptic Drugs. | 2018 |
1 |
| 14 |
26966071 | Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells. | 2016 Apr 15 |
1 |
| 15 |
27450623 | Interactions between non-vitamin K oral anticoagulants and antiepileptic drugs. | 2016 Oct |
1 |
| 16 |
27713827 | Evaluation of a novel PXR-knockout in HepaRG™ cells. | 2016 Oct |
1 |
| 17 |
25600204 | Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays. | 2015 |
1 |
| 18 |
24553381 | Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes P450. | 2014 May |
1 |
| 19 |
24674673 | Cytochrome P450 genetic polymorphism in neonatal drug metabolism: role and practical consequences towards a new drug culture in neonatology. | 2014 Jan-Mar |
1 |
| 20 |
23212742 | Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: implications for drug-induced osteomalacia. | 2013 May |
1 |
| 21 |
21998292 | The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction. | 2012 Jan |
1 |
| 22 |
21111054 | Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2. | 2011 May-Jun |
1 |
| 23 |
21832258 | Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction. | 2011 Sep |
1 |
| 24 |
20019244 | Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. | 2010 Mar |
1 |
| 25 |
20369030 | Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives. | 2010 Mar 1 |
1 |
| 26 |
20583967 | A multi-endpoint evaluation of cytochrome P450 1A2, 2B6 and 3A4 induction response in human hepatocyte cultures after treatment with β-naphthoflavone, phenobarbital and rifampicin. | 2010 Dec |
1 |
| 27 |
20837660 | Metabolism and action of proteasome inhibitors in primary human hepatocytes. | 2010 Dec |
1 |
| 28 |
18983865 | Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes. | 2009 Jan 15 |
2 |
| 29 |
19202563 | Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes. | 2009 Jan-Feb |
1 |
| 30 |
19451401 | Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers. | 2009 Aug |
1 |
| 31 |
17826359 | Effects of mammalian CYP3A inducers on CYP3A-related enzyme activities in grass carp (Ctenopharyngodon idellus): Possible implications for the establishment of a fish CYP3A induction model. | 2008 Jan |
2 |
| 32 |
18022748 | Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes. | 2008 Jan 14 |
1 |
| 33 |
18094037 | Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. | 2008 Mar |
2 |
| 34 |
18328680 | Coordinated induction of drug transporters and phase I and II metabolism in human liver slices. | 2008 Apr 23 |
1 |
| 35 |
18332078 | Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction. | 2008 Jun |
1 |
| 36 |
18468591 | Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes. | 2008 Jun 17 |
1 |
| 37 |
18989830 | Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies. | 2008 Dec |
1 |
| 38 |
16291874 | Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. | 2006 Mar |
2 |
| 39 |
17190925 | Optimizing therapy of seizures in women who use oral contraceptives. | 2006 Dec 26 |
1 |
| 40 |
15747502 | Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2. | 2005 |
1 |
| 41 |
15832810 | Induction of phase I, II and III drug metabolism/transport by xenobiotics. | 2005 Mar |
1 |
| 42 |
15833926 | Arsenite decreases CYP3A4 and RXRalpha in primary human hepatocytes. | 2005 Jul |
2 |
| 43 |
16276979 | Effect of Cimetidine and Phenobarbital on metabolite kinetics of Omeprazole in rats. | 2005 Oct |
1 |
| 44 |
14977870 | Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers. | 2004 Mar |
1 |
| 45 |
15100175 | Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene. | 2004 May |
1 |
| 46 |
15382119 | Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance. | 2004 Oct |
1 |
| 47 |
12673034 | Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor. | 2003 Apr |
3 |
| 48 |
12815172 | Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation. | 2003 Jul |
1 |
| 49 |
14522368 | The role of chemotherapy in brain metastases. | 2003 Oct |
1 |
| 50 |
12065438 | CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. | 2002 Jul |
2 |