4-amidinoindan-1-one 2'-amidinohydrazone

adenosylmethionine decarboxylase 1 ; Homo sapiens







14 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 31140554 Polyamine synthesis enzyme AMD1 is closely associated with tumorigenesis and prognosis of human gastric cancers. 2020 Apr 22 1
2 19584241 Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma. 2009 Jul 2
3 15965903 Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha. 2006 Jan 2
4 16007177 Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells. 2005 Aug 25 2
5 16170669 Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells. 2005 2
6 15547724 Biological activity of the S-adenosylmethionine decarboxylase inhibitor SAM486A in human breast cancer cells in vitro and in vivo. 2004 Dec 3
7 15704548 The role of polyamines in human cancer: prospects for drug combination therapies. 2004 Dec 1
8 14535654 Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 1. Selective enzyme inhibitors. 2003 Oct 1
9 12114416 A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies. 2002 Jul 3
10 11698350 Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines. 2001 Nov 2
11 10944598 A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. 2000 Sep 6
12 8877009 Structure-activity relations of S-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells. 1996 1
13 7635576 Biochemical and growth-modulatory effects of the new S-adenosylmethionine decarboxylase inhibitor CGP 48664 in malignant and immortalized normal human breast epithelial cells in culture. 1995 Aug 9 2
14 7640515 Treatment of nude mice with 4-amidinoindan -1- one2 '- amidinohydrazone, a new S-adenosylmethionine decarboxylase inhibitor, delays growth and inhibits metastasis of human melanoma cells. 1995 Jun 2