| 1 |
34743990 | Regulation of NAD+ metabolism in aging and disease. | 2022 Jan |
1 |
| 2 |
33550969 | Novel Niacin Receptor Agonists: A Promising Strategy for the Treatment of Dyslipidemia. | 2021 |
1 |
| 3 |
33674782 | Expanding the drug discovery space with predicted metabolite-target interactions. | 2021 Mar 5 |
1 |
| 4 |
33708203 | Role of HCA2 in Regulating Intestinal Homeostasis and Suppressing Colon Carcinogenesis. | 2021 |
1 |
| 5 |
34681211 | The Specificity and Broad Multitarget Properties of Ligands for the Free Fatty Acid Receptors FFA3/GPR41 and FFA2/GPR43 and the Related Hydroxycarboxylic Acid Receptor HCA2/GPR109A. | 2021 Sep 28 |
2 |
| 6 |
34803497 | GPR109A alleviate mastitis and enhances the blood milk barrier by activating AMPK/Nrf2 and autophagy. | 2021 |
1 |
| 7 |
34866904 | Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor. | 2021 |
4 |
| 8 |
34916973 | Inflammation and JNK's Role in Niacin-GPR109A Diminished Flushed Effect in Microglial and Neuronal Cells With Relevance to Schizophrenia. | 2021 |
1 |
| 9 |
33374784 | Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease. | 2020 Dec 23 |
1 |
| 10 |
31268250 | A Randomized, Placebo-Controlled Trial to Assess the Effects of 8 Weeks of Administration of GSK256073, a Selective GPR109A Agonist, on High-Density Lipoprotein Cholesterol in Subjects With Dyslipidemia. | 2019 Oct |
2 |
| 11 |
31273921 | Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2 ). | 2019 Sep |
4 |
| 12 |
31617441 | Activation of HCAR2 by niacin: benefits beyond lipid lowering. | 2019 Nov |
3 |
| 13 |
29473951 | 4-Hydroxynonenal-induced GPR109A (HCA2 receptor) activation elicits bipolar responses, Gαi -mediated anti-inflammatory effects and Gβγ -mediated cell death. | 2018 Jul |
1 |
| 14 |
29759143 | Niacin modulates macrophage polarization in Parkinson's disease. | 2018 Jul 15 |
1 |
| 15 |
30270326 | Hydroxycarboxylic Acid Receptor Ligands Modulate Proinflammatory Cytokine Expression in Human Macrophages and Adipocytes without Affecting Adipose Differentiation. | 2018 |
1 |
| 16 |
28186140 | Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization. | 2017 Feb 10 |
2 |
| 17 |
26656756 | The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells. | 2016 Jan 5 |
1 |
| 18 |
26932224 | Niacin Alternatives for Dyslipidemia: Fool's Gold or Gold Mine? Part II: Novel Niacin Mimetics. | 2016 Apr |
2 |
| 19 |
25599616 | Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptor. | 2015 Jun |
1 |
| 20 |
25773497 | Discovery and characterization of GSK256073, a non-flushing hydroxy-carboxylic acid receptor 2 (HCA2) agonist. | 2015 Jun 5 |
6 |
| 21 |
26273459 | Low-dose niacin supplementation modulates GPR109A, niacin index and ameliorates Parkinson's disease symptoms without side effects. | 2015 Jul |
1 |
| 22 |
26531288 | Formulation and in vitro evaluation of niacin-loaded nanoparticles to reduce prostaglandin mediated vasodilatory flushing. | 2015 Oct |
2 |
| 23 |
24371223 | The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival. | 2014 Feb 15 |
1 |
| 24 |
24433041 | Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery. | 2014 Mar |
1 |
| 25 |
24662263 | Niacin activates the G protein estrogen receptor (GPER)-mediated signalling. | 2014 Jul |
1 |
| 26 |
24767308 | Structure-dependent effects of pyridine derivatives on mechanisms of intestinal fatty acid uptake: regulation of nicotinic acid receptor and fatty acid transporter expression. | 2014 Jul |
1 |
| 27 |
24768191 | Short-term effects of extended-release niacin with and without the addition of laropiprant on endothelial function in individuals with low HDL-C: a randomized, controlled crossover trial. | 2014 Jun 1 |
1 |
| 28 |
25320346 | Inflammation stimulates niacin receptor (GPR109A/HCA2) expression in adipose tissue and macrophages. | 2014 Dec |
2 |
| 29 |
25329911 | Upregulation of GPR109A in Parkinson's disease. | 2014 |
1 |
| 30 |
25375133 | Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2. | 2014 |
4 |
| 31 |
25455298 | A novel treatment target for Parkinson's disease. | 2014 Dec 15 |
3 |
| 32 |
25463108 | Niacin receptor activation improves human microvascular endothelial cell angiogenic function during lipotoxicity. | 2014 Dec |
1 |
| 33 |
25911818 | [Discovery of potential nicotinic acid receptor agonists from Chinese herbal medicines based on molecular simulation]. | 2014 Dec |
1 |
| 34 |
23526298 | GPR109A and vascular inflammation. | 2013 May |
2 |
| 35 |
23770183 | Differential tissue and ligand-dependent signaling of GPR109A receptor: implications for anti-atherosclerotic therapeutic potential. | 2013 Oct |
6 |
| 36 |
24184940 | Niacin: a long history, but a questionable future. | 2013 Dec |
4 |
| 37 |
22267479 | Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms. | 2012 Mar |
1 |
| 38 |
22435740 | (1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. | 2012 Apr 26 |
1 |
| 39 |
22743741 | Role of HCA₂ (GPR109A) in nicotinic acid and fumaric acid ester-induced effects on the skin. | 2012 Oct |
2 |
| 40 |
22914620 | It ain't over 'til the fat lady sings. | 2012 Aug 22 |
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| 41 |
22914621 | Niacin lipid efficacy is independent of both the niacin receptor GPR109A and free fatty acid suppression. | 2012 Aug 22 |
3 |
| 42 |
22962331 | Identification and characterization of distinct C-terminal domains of the human hydroxycarboxylic acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization. | 2012 Dec |
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| 43 |
21418500 | Future of GPR109A agonists in the treatment of dyslipidaemia. | 2011 Aug |
3 |
| 44 |
21655214 | Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. | 2011 |
1 |
| 45 |
21768093 | Distinct kinetic and spatial patterns of protein kinase C (PKC)- and epidermal growth factor receptor (EGFR)-dependent activation of extracellular signal-regulated kinases 1 and 2 by human nicotinic acid receptor GPR109A. | 2011 Sep 9 |
4 |
| 46 |
21907911 | Biological and pharmacological roles of HCA receptors. | 2011 |
3 |
| 47 |
21943747 | An unusual distribution of the niacin receptor in cattle. | 2011 Oct |
3 |
| 48 |
19781706 | Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin. | 2010 Mar |
1 |
| 49 |
20460384 | Internalization of the human nicotinic acid receptor GPR109A is regulated by G(i), GRK2, and arrestin3. | 2010 Jul 16 |
3 |
| 50 |
20615702 | GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a. | 2010 Aug 1 |
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