Cerulenin

fatty acid synthase ; Homo sapiens







70 Article(s)
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51 14999148 Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/ neu -overexpressing human breast cancer cells to docetaxel (taxotere). 2004 Mar 1
52 15047835 Fatty acid synthase expression is induced by the Epstein-Barr virus immediate-early protein BRLF1 and is required for lytic viral gene expression. 2004 Apr 1
53 15138577 Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. 2004 Jun 2
54 15172643 Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells. 2004 Aug 1
55 15235125 Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. 2004 Jul 20 1
56 15254710 Inhibition of tumor-associated fatty acid synthase activity enhances vinorelbine (Navelbine)-induced cytotoxicity and apoptotic cell death in human breast cancer cells. 2004 Aug 1
57 15390078 Pharmacological inhibition of fatty acid synthase (FAS): a novel therapeutic approach for breast cancer chemoprevention through its ability to suppress Her-2/neu (erbB-2) oncogene-induced malignant transformation. 2004 Nov 1
58 12820377 Characterization and inhibition of fatty acid synthase in pediatric tumor cell lines. 2003 Mar-Apr 2
59 11935210 Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells. 2002 Mar 1
60 12181752 Key role of mitochondria in cerulenin-mediated apoptosis. 2002 Sep 1
61 12213216 Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. 2002 Sep 10 1
62 11245456 Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. 2001 Feb 15 2
63 11866903 [An experimental study on cerulenin induced apoptosis of human colonic cancer cells]. 2000 Apr 1
64 11866947 [Cerulenin inhibits growth of human colonic carcinoma in nude mice]. 2000 Dec 1
65 11876988 [Proliferation inhibition and apoptosis induction of K562 cells by fatty acid synthase inhibitor--cerulenin]. 2000 May 4
66 9593836 Characterization of fatty acid synthase in cell lines derived from experimental mammary tumors. 1998 May 20 2
67 9788612 Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines. 1998 Oct 15 2
68 8631008 Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells. 1996 Feb 15 3
69 8665507 Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells. 1996 Jun 15 1
70 8022791 Fatty acid synthesis: a potential selective target for antineoplastic therapy. 1994 Jul 5 2