polyglutamine

ataxin 7 ; Homo sapiens







84 Article(s)
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51 17344386 A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes. 2007 Mar 7 3
52 17646170 Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation. 2007 Oct 12 1
53 17868456 HAP1 can sequester a subset of TBP in cytoplasmic inclusions via specific interaction with the conserved TBP(CORE). 2007 Sep 14 4
54 17994014 Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. 2007 Dec 2
55 15964171 Polyglutamine-expanded ataxin-7 activates mitochondrial apoptotic pathway of cerebellar neurons by upregulating Bax and downregulating Bcl-x(L). 2006 Apr 7
56 16314424 Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal. 2006 Feb 3 5
57 16325416 Polyglutamine and polyalanine expansions in ataxin7 result in different types of aggregation and levels of toxicity. 2006 Mar 4
58 16626296 Both normal and polyglutamine- expanded ataxin-7 are components of TFTC-type GCN5 histone acetyltransferase- containing complexes. 2006 2
59 16962040 [Role of chromatin alterations in neurodegeneration induced by polyglutamine-expanded ataxin-7]. 2006 Aug-Sep 1
60 15895563 The pathogenesis of spinocerebellar ataxia. 2005 2
61 15932940 Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. 2005 Jun 14 7
62 15932941 Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity. 2005 Jun 14 3
63 15936949 A role for both wild-type and expanded ataxin-7 in transcriptional regulation. 2005 Dec 1
64 15989694 Spinocerebellar ataxia type 17: report of a family with reduced penetrance of an unstable Gln49 TBP allele, haplotype analysis supporting a founder effect for unstable alleles and comparative analysis of SCA17 genotypes. 2005 Jul 1 2
65 14571264 Spinocerebellar ataxia type 7 associated with pigmentary retinal dystrophy. 2004 Jan 4
66 14613968 Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization. 2004 Jan 1 3
67 15115762 Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes. 2004 Jun 15 5
68 12490531 Genomic context drives SCA7 CAG repeat instability, while expressed SCA7 cDNAs are intergenerationally and somatically stable in transgenic mice. 2003 Jan 1 1
69 12533095 A novel central nervous system-enriched spinocerebellar ataxia type 7 gene product. 2003 Jan 5
70 12699716 Dysregulatory dysequilibrium of gene transcription and of nuclear transport in polyglutamine neuro-degeneration. 2003 Jun 1
71 12758065 Molecular investigation of TBP allele length: a SCA17 cellular model and population study. 2003 Jun 1
72 14526176 Spinocerebellar ataxia 7 (SCA7). 2003 1
73 12070661 Expression of ataxin-7 in CNS and non-CNS tissue of normal and SCA7 individuals. 2002 Jul 1
74 12077003 Two populations of neuronal intranuclear inclusions in SCA7 differ in size and promyelocytic leukaemia protein content. 2002 Jul 2
75 11354830 Ataxin-7 expression analysis in controls and spinocerebellar ataxia type 7 patients. 2001 Mar 1
76 11448935 SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. 2001 Jul 1 1
77 11719247 Transglutaminase-dependent formation of protein aggregates as possible biochemical mechanism for polyglutamine diseases. 2001 Oct-Nov 1 1
78 12235815 [SCA17, a novel polyglutamine disease caused by the expansion of polyglutamine tracts in TATA-binding protein]. 2001 Dec 1
79 10712199 High germinal instability of the (CTG)n at the SCA8 locus of both expanded and normal alleles. 2000 Mar 1
80 10841760 Conserved phosphoprotein interaction motif is functionally interchangeable between ataxin-7 and arrestins. 2000 Jun 13 2
81 10885657 Expression analysis of ataxin-7 mRNA and protein in human brain: evidence for a widespread distribution and focal protein accumulation. 2000 Jul 1
82 10928570 The molecular biology of the autosomal-dominant cerebellar ataxias. 2000 Jul 1
83 10970064 Recent advances in degenerative ataxias. 2000 Aug 1
84 10640674 Identification and localization of ataxin-7 in brain and retina of a patient with cerebellar ataxia type II using anti-peptide antibody. 1999 Dec 10 2