Lacosamide

dihydropyrimidinase like 2 ; Homo sapiens







12 Article(s)
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1 35334412 CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy. 2022 May 21 1
2 34685760 CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons. 2021 Oct 17 2
3 30022576 Mammalian target of rapamycin complex 1 and its downstream effector collapsin response mediator protein-2 drive reinstatement of alcohol reward seeking. 2019 Sep 1
4 28660485 CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation. 2018 May 1
5 30169428 Lacosamide modulates collapsin response mediator protein 2 and inhibits mossy fiber sprouting after kainic acid-induced status epilepticus. 2018 Nov 7 4
6 26952865 mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors. 2017 Jan 1
7 28809766 CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide. 2017 Dec 2
8 25846820 (S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5. 2016 Apr 2
9 26967696 (S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology. 2016 Jul 2
10 24944082 Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide. 2015 Apr 10
11 25104922 The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth. 2014 3
12 18972867 [Lacosamide. A new antiepileptic drug as adjunctive therapy in patients with partial-onset seizures]. 2008 Oct 2