Guanine Nucleotides

TIAM Rac1 associated GEF 1 ; Homo sapiens







17 Article(s)
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Title
Pub. Year
#Total Relationships
1 34624316 Identification of Rac guanine nucleotide exchange factors promoting Lgl1 phosphorylation in glioblastoma. 2021 Nov 1
2 33200195 Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease. 2020 Dec 18 2
3 29178143 Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases. 2017 Nov 27 1
4 24501217 Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells. 2014 Apr 3 2
5 25014207 Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1. 2014 1
6 21111731 p190RhoGAP mediates protective effects of oxidized phospholipids in the models of ventilator-induced lung injury. 2011 Apr 1 1
7 21943825 Inactivation of Rac1 reduces Trastuzumab resistance in PTEN deficient and insulin-like growth factor I receptor overexpressing human breast cancer SKBR3 cells. 2011 Dec 26 1
8 19893486 The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. 2010 Jan 6 1
9 20496116 EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor. 2010 Jun 1
10 18925966 The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer. 2008 Oct 16 1
11 18997336 Crystallographic characterization of the membrane-targeting domains of the Rac-specific guanine nucleotide-exchange factors Tiam1 and Tiam2. 2008 Nov 1 2
12 12810717 Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. 2003 Sep 5 1
13 12134164 Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. 2002 Aug 1
14 10835422 Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands. 2000 Aug 18 1
15 11130063 Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. 2000 Dec 7 2
16 10320937 Rho-like GTPases: their role in cell adhesion and invasion. 1999 1
17 10579721 Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior. 1999 Nov 29 1