| 1 |
33894161 | Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury. | 2021 Sep 16 |
1 |
| 2 |
34809463 | Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. | 2021 Dec 21 |
2 |
| 3 |
32369692 | Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells. | 2020 May 6 |
2 |
| 4 |
32622856 | FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention. | 2020 Nov |
2 |
| 5 |
32661607 | Role of FK506 Binding Protein on Tacrolimus Distribution in Red Blood Cells. | 2020 Jul 13 |
3 |
| 6 |
33195437 | Interactions of FK506 and Rapamycin With FK506 Binding Protein 12 in Opportunistic Human Fungal Pathogens. | 2020 |
7 |
| 7 |
30827938 | Activation of BMP Signaling by FKBP12 Ligands Synergizes with Inhibition of CXCR4 to Accelerate Wound Healing. | 2019 May 16 |
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| 8 |
31100260 | BMPing Up Healing Capacity with FKBP12 Ligand. | 2019 May 16 |
1 |
| 9 |
31531197 | One-step Heck Reaction Generates Nonimmunosuppressive FK506 Analogs for Pharmacological BMP Activation. | 2019 Sep 12 |
1 |
| 10 |
31537789 | Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. | 2019 Sep 19 |
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| 11 |
29131377 | New insights of subfertility among transplanted women: Immunosuppressive drug FK506 leads to calcium leak and oocyte activation before fertilization. | 2018 Mar |
2 |
| 12 |
30181374 | In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates. | 2018 Nov |
1 |
| 13 |
28108248 | A new efficient method of generating photoaffinity beads for drug target identification. | 2017 Feb 15 |
1 |
| 14 |
27193181 | II. Dissociation free energies in drug-receptor systems via nonequilibrium alchemical simulations: application to the FK506-related immunophilin ligands. | 2016 Jun 1 |
2 |
| 15 |
24471694 | The full electron structure of the FKBP12/FK506 complex. | 2015 |
4 |
| 16 |
25986568 | FK506-Binding Proteins and Their Diverse Functions. | 2015 |
1 |
| 17 |
26073814 | Label-free quantification of Tacrolimus in biological samples by atomic force microscopy. | 2015 Jul 16 |
1 |
| 18 |
26322864 | Selective Targeting of Cells via Bispecific Molecules That Exploit Coexpression of Two Intracellular Proteins. | 2015 Nov 20 |
1 |
| 19 |
26561008 | Differential Large-Amplitude Breathing Motions in the Interface of FKBP12-Drug Complexes. | 2015 Dec 1 |
1 |
| 20 |
24816588 | Tacrolimus increases Nox4 expression in human renal fibroblasts and induces fibrosis-related genes by aberrant TGF-beta receptor signalling. | 2014 |
1 |
| 21 |
24846380 | Bioluminescence resonance energy transfer system for measuring dynamic protein-protein interactions in bacteria. | 2014 May 20 |
2 |
| 22 |
26579923 | Energy-Driven Undocking (EDU-HREM) in Solute Tempering Replica Exchange Simulations. | 2014 Jan 14 |
1 |
| 23 |
23224428 | Functional diversity and pharmacological profiles of the FKBPs and their complexes with small natural ligands. | 2013 Sep |
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| 24 |
23989449 | ScFKBP12 bridges rapamycin and AtTOR in Arabidopsis. | 2013 Nov |
4 |
| 25 |
24092409 | A new protein-protein interaction sensor based on tripartite split-GFP association. | 2013 Oct 4 |
1 |
| 26 |
21466465 | Targeting FK506 binding proteins to fight malarial and bacterial infections: current advances and future perspectives. | 2011 |
2 |
| 27 |
21518964 | Tacrolimus-induced hypertension: what's endothelial and hematopoietic FKBP12 got to do with it? | 2011 Jun |
1 |
| 28 |
21182472 | FK506 binding proteins as targets in anticancer therapy. | 2010 Nov 1 |
2 |
| 29 |
19201607 | Improvement of monolithic solid material by utilization of spacer for identification of the target using affinity resins. | 2009 Mar 1 |
1 |
| 30 |
19361439 | Differential responses of the backbone and side-chain conformational dynamics in FKBP12 upon binding the transition-state analog FK506: implications for transition-state stabilization and target protein recognition. | 2009 Mar 20 |
4 |
| 31 |
18465874 | Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506. | 2008 Jun 3 |
4 |
| 32 |
18038971 | Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors. | 2007 Dec 27 |
1 |
| 33 |
16290149 | Development of chemically stable solid phases for the target isolation with reduced nonspecific binding proteins. | 2006 Jan 15 |
1 |
| 34 |
16410343 | The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy. | 2006 Mar |
1 |
| 35 |
16490780 | Establishment of a cell model based on FKBP12 dimerization for screening of FK506-like neurotrophic small molecular compounds. | 2006 Apr |
4 |
| 36 |
16844742 | Absolute binding free energy calculations using molecular dynamics simulations with restraining potentials. | 2006 Oct 15 |
1 |
| 37 |
17082615 | The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes. | 2006 Nov 15 |
1 |
| 38 |
17176100 | Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins. | 2006 Dec 26 |
3 |
| 39 |
15937899 | Statistical and molecular dynamics studies of buried waters in globular proteins. | 2005 Aug 15 |
1 |
| 40 |
15144206 | A mammalian genetic system to screen for small molecules capable of disrupting protein-protein interactions. | 2004 May 15 |
1 |
| 41 |
12499534 | Structure of the N-terminal domain of human FKBP52. | 2003 Jan |
2 |
| 42 |
12502928 | Expression of FKBP12 in benign and malignant vascular endothelium: an immunohistochemical study on conventional sections and tissue microarrays. | 2003 Jan |
1 |
| 43 |
14581219 | Design and structure-based study of new potential FKBP12 inhibitors. | 2003 Nov |
2 |
| 44 |
14623295 | Structures of calcineurin and its complexes with immunophilins-immunosuppressants. | 2003 Nov 28 |
2 |
| 45 |
11841938 | Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors. | 2002 Jan |
1 |
| 46 |
12135494 | Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit. | 2002 Jul |
1 |
| 47 |
12137728 | Tacrolimus ointment: a new therapy for atopic dermatitis--review of the literature. | 2002 Mar |
1 |
| 48 |
14599350 | High-throughput fluorescence polarization method for identification of FKBP12 ligands. | 2002 Dec |
1 |
| 49 |
11054412 | Selectively suppressed Ca2+-induced Ca2+ release activity of alpha-ryanodine receptor (alpha-RyR) in frog skeletal muscle sarcoplasmic reticulum: potential distinct modes in Ca2+ release between alpha- and beta-RyR. | 2001 Jan 26 |
1 |
| 50 |
11418477 | Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages. | 2001 Jul 1 |
1 |