| 1 |
34461224 | Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation. | 2021 Oct |
1 |
| 2 |
33597925 | Simvastatin and ROCK Inhibitor Y-27632 Inhibit Myofibroblast Differentiation of Graves' Ophthalmopathy-Derived Orbital Fibroblasts via RhoA-Mediated ERK and p38 Signaling Pathways. | 2020 |
3 |
| 3 |
31325047 | 20(S)-hydroxycholesterol and simvastatin synergistically enhance osteogenic differentiation of marrow stromal cells and bone regeneration by initiation of Raf/MEK/ERK signaling. | 2019 Jul 19 |
1 |
| 4 |
29257256 | Simvastatin ameliorates cognitive impairments via inhibition of oxidative stress‑induced apoptosis of hippocampal cells through the ERK/AKT signaling pathway in a rat model of senile dementia. | 2018 Jan |
1 |
| 5 |
30513525 | Simvastatin Protects Dopaminergic Neurons Against MPP+-Induced Oxidative Stress and Regulates the Endogenous Anti-Oxidant System Through ERK. | 2018 |
2 |
| 6 |
26470769 | Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells. | 2016 Mar |
1 |
| 7 |
26565813 | Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. | 2016 Jan 19 |
3 |
| 8 |
26875818 | Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways. | 2016 Jun |
1 |
| 9 |
27123120 | Simvastatin blocks TGF-β1-induced epithelial-mesenchymal transition in human prostate cancer cells. | 2016 May |
1 |
| 10 |
27323826 | Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer. | 2016 Jul 19 |
3 |
| 11 |
27347133 | Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. | 2016 Jul |
4 |
| 12 |
25631750 | Simvastatin downregulates expression of TGF-βRII and inhibits proliferation of A549 cells via ERK. | 2015 Jun |
3 |
| 13 |
24856644 | Effects of peroxisome proliferator-activated receptor γ in simvastatin antiplatelet activity: influences on cAMP and mitogen-activated protein kinases. | 2014 Jul |
2 |
| 14 |
25262449 | Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition. | 2014 Nov |
2 |
| 15 |
23228261 | Combined effects of simvastatin and enamel matrix derivative on odontoblastic differentiation of human dental pulp cells. | 2013 Jan |
5 |
| 16 |
23558220 | Decreased tissue levels of cyclophilin A, a cyclosporine a target and phospho-ERK1/2 in simvastatin patients with abdominal aortic aneurysm. | 2013 Jun |
1 |
| 17 |
23690956 | Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway. | 2013 |
3 |
| 18 |
24080182 | Simvastatin increases Prolyl-4-Hydroxylase α1 expression in atherosclerotic plaque and ox-LDL-stimulated human aortic smooth muscle cells via p38 MAPK and ERK1/2 signaling. | 2013 Dec |
4 |
| 19 |
22386866 | Different signaling mechanisms regulating IL-6 expression by LPS between gingival fibroblasts and mononuclear cells: seeking the common target. | 2012 May |
1 |
| 20 |
23045963 | Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells. | 2012 Dec |
2 |
| 21 |
20346376 | Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling. | 2010 Jun 8 |
3 |
| 22 |
20417880 | Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway. | 2010 Mar |
3 |
| 23 |
18371146 | Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. | 2008 Apr |
2 |
| 24 |
18489904 | Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. | 2008 Jul 25 |
1 |
| 25 |
18625914 | Simvastatin suppresses LPS-induced MMP-1 expression in U937 mononuclear cells by inhibiting protein isoprenylation-mediated ERK activation. | 2008 Oct |
4 |
| 26 |
17428261 | Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. | 2007 Jun |
1 |
| 27 |
17464346 | The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells. | 2007 Feb |
2 |
| 28 |
16170339 | Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling. | 2006 Feb 9 |
3 |
| 29 |
15069546 | Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells. | 2004 May |
1 |
| 30 |
15136060 | Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDL. | 2004 Jun |
1 |
| 31 |
15262179 | Simvastatin suppresses coronary artery endothelial tube formation by disrupting Ras/Raf/ERK signaling. | 2004 Aug |
4 |