4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole

mitogen-activated protein kinase 1 ; Homo sapiens







75 Article(s)
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1 35294968 Oxidative Stress-induced Autophagy Compromises Stem Cell Viability. 2022 May 27 1
2 34959222 Free fatty acids-induced neutrophil extracellular traps lead to dendritic cells activation and T cell differentiation in acute lung injury. 2021 Dec 27 1
3 32104150 Dexmedetomidine Attenuates Monocyte-Endothelial Adherence via Inhibiting Connexin43 on Vascular Endothelial Cells. 2020 1
4 29466417 Epinephrine modulates Na+/K+ ATPase activity in Caco-2 cells via Src, p38MAPK, ERK and PGE2. 2018 1
5 29577978 Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation. 2018 Jul 1
6 28314481 Benzophenones and xanthone derivatives from Garcinia schomburgkiana-induced P-glycoprotein overexpression in human colorectal Caco-2 cells via oxidative stress-mediated mechanisms. 2017 Apr 15 1
7 28393288 Differential effects of p38 MAP kinase inhibitors SB203580 and SB202190 on growth and migration of human MDA-MB-231 cancer cell line. 2017 Aug 2
8 28537766 Pirfenidone Induces G1 Arrest in Human Tenon's Fibroblasts In Vitro Involving AKT and MAPK Signaling Pathways. 2017 Jun 1
9 28801998 Resistin-Like Molecule Beta (RELM-β) Regulates Proliferation of Human Diabetic Nephropathy Mesangial Cells via Mitogen-Activated Protein Kinases (MAPK) Signaling Pathway. 2017 Aug 12 1
10 29118901 Impacts of berberine on oxidized LDL-induced proliferation of human umbilical vein endothelial cells. 2017 1
11 26861294 p38 MAPK Is Activated but Does Not Play a Key Role during Apoptosis Induction by Saturated Fatty Acid in Human Pancreatic β-Cells. 2016 Feb 5 2
12 25998312 Cadmium Induced Apoptosis in MG63 Cells by Increasing ROS, Activation of p38 MAPK and Inhibition of ERK 1/2 Pathways. 2015 1
13 24874889 Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells. 2014 Aug 1
14 25530682 LPS- and LTA-induced expression of IL-6 and TNF-α in neonatal and adult blood: role of MAPKs and NF-κB. 2014 1
15 23784034 Acid‑induced cell injury and death in lung epithelial cells is associated with the activation of mitogen‑activated protein kinases. 2013 Aug 1
16 22490436 Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells. 2012 May 1
17 21853067 SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition. 2011 2
18 22074828 Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells. 2011 Dec 2 1
19 20067818 Cellular and molecular mechanisms of bromate-induced cytotoxicity in human and rat kidney cells. 2010 Feb 28 1
20 20405237 Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage. 2010 Jun 1
21 20419833 Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells. 2010 Apr 28 1
22 20506406 Taiwan cobra phospholipase A2 elicits posttranscriptional up-regulation of ADAM17 in human neuroblastoma SK-N-SH cells. 2010 Sep 1 1
23 19180563 ROS-mediated p38alpha MAPK activation and ERK inactivation responsible for upregulation of Fas and FasL and autocrine Fas-mediated cell death in Taiwan cobra phospholipase A(2)-treated U937 cells. 2009 Jun 1
24 19652200 Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation. 2009 Sep 24 1
25 17996917 Fluoride-induced IL-8 release in human epithelial lung cells: relationship to EGF-receptor-, SRC- and MAP-kinase activation. 2008 Feb 15 1
26 18074350 p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4. 2008 Apr 15 2
27 18285354 Effects of advanced glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chondrocytes. 2008 Apr 1
28 18588859 TGF-beta activates ERK5 in human renal epithelial cells. 2008 Aug 29 1
29 17433832 Mitogen-activated protein kinase proteins regulate LPS-stimulated release of pro-inflammatory cytokines and prostaglandins from human gestational tissues. 2007 Aug-Sep 1
30 17457195 Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. 2007 May 1
31 17464174 p38 MAPK and ERK activation by 9-cis-retinoic acid induces chemokine receptors CCR1 and CCR2 expression in human monocytic THP-1 cells. 2007 Apr 30 2
32 17482227 2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB. 2007 Jun 15 1
33 17543571 ERK1/2 inactivation and p38 MAPK-dependent caspase activation during guanosine 5'-triphosphate-mediated terminal erythroid differentiation of K562 cells. 2007 2
34 17617469 Involvement of p38 MAP kinase in lipopolysaccharide-induced production of pro- and anti-inflammatory cytokines and prostaglandin E(2) in human choriodecidua. 2007 Oct 2
35 17671214 Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. 2007 Aug 1 1
36 16186797 A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis. 2006 Feb 2 2
37 16202406 JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. 2006 Apr 1
38 16475830 Inhibition of apolipoprotein AI gene expression by tumor necrosis factor alpha: roles for MEK/ERK and JNK signaling. 2006 Feb 21 1
39 16497166 Modulation of autocrine TNF-alpha-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogen-activated protein kinases in THP-1 monocytic cells. 2006 Jan 1
40 16672323 Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis. 2006 Aug 1
41 16963169 Mechanisms of silica-induced IL-8 release from A549 cells: initial kinase-activation does not require EGFR activation or particle uptake. 2006 Oct 3 2
42 17202844 The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways. 2006 Dec 31 1
43 15833272 The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain. 2005 Jul 1
44 14722101 Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase. 2004 Mar 19 1
45 14977049 Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation. 2004 Jan 1
46 15075366 The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho. 2004 Jun 1
47 15100728 [Angiotensin II-induced podocyte apoptosis: role of the MAPK subtypes]. 2004 Apr 1
48 15256218 Combined action of extracellular signal-regulated kinase and p38 kinase rescues Molt4 T cells from nitric oxide-induced apoptotic and necrotic cell death. 2004 Aug 15 1
49 15489211 Methyl selenium-induced vascular endothelial apoptosis is executed by caspases and principally mediated by p38 MAPK pathway. 2004 1
50 12605455 MAPK signal transduction pathway mediates agrin effects on neurite elongation in cultured hippocampal neurons. 2003 Apr 2