2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

mitogen-activated protein kinase 1 ; Homo sapiens







1260 Article(s)
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101 30335889 Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells. 2018 Oct 18 2
102 30337961 Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells. 2018 3
103 30458452 Sulforaphane-N-Acetyl-Cysteine Induces Autophagy Through Activation of ERK1/2 in U87MG and U373MG Cells. 2018 1
104 30465574 Licochalcone A inhibits the invasive potential of human glioma cells by targeting the MEK/ERK and ADAM9 signaling pathways. 2018 Dec 13 1
105 30555255 Inhibiting GIT1 reduces the growth, invasion, and angiogenesis of osteosarcoma. 2018 1
106 30562745 MACROD1/LRP16 Enhances LPS-Stimulated Inflammatory Responses by Up-Regulating a Rac1-Dependent Pathway in Adipocytes. 2018 1
107 30622592 Neuroprotective Effects of Gagam-Sipjeondaebo-Tang, a Novel Herbal Formula, against MPTP-Induced Parkinsonian Mice and MPP+-Induced Cell Death in SH-SY5Y Cells. 2018 1
108 30662622 CXCL16 is activated by p-JNK and is involved in H2O2-induced HK-2 cell injury via p-ERK signaling. 2018 1
109 27864646 Low-level laser irradiation modulates brain-derived neurotrophic factor mRNA transcription through calcium-dependent activation of the ERK/CREB pathway. 2017 Jan 1
110 28000882 Modulation of low shear stress‑induced eNOS multi‑site phosphorylation and nitric oxide production via protein kinase and ERK1/2 signaling. 2017 Feb 1
111 28167851 IL-1β-Induced Accumulation of Amyloid: Macroautophagy in Skeletal Muscle Depends on ERK. 2017 1
112 28178193 Cearoin Induces Autophagy, ERK Activation and Apoptosis via ROS Generation in SH-SY5Y Neuroblastoma Cells. 2017 Feb 6 2
113 28223944 IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes. 2017 1
114 28381458 Protein phosphatase 2C is responsible for VP-induced dephosphorylation of AQP2 serine 261. 2017 Aug 1 2
115 28383556 Synovial cell death is regulated by TNF-α-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1α. 2017 Apr 6 1
116 28487957 Chemokine (C‑C motif) ligand 21/C‑C chemokine receptor type 7 triggers migration and invasion of human lung cancer cells by epithelial‑mesenchymal transition via the extracellular signal‑regulated kinase signaling pathway. 2017 Jun 1
117 28524116 Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells. 2017 May 18 4
118 28535663 Up-Regulation of RANK Expression via ERK1/2 by Insulin Contributes to the Enhancement of Osteoclast Differentiation. 2017 May 31 1
119 28543279 Role of AMPA receptors in homocysteine-NMDA receptor-induced crosstalk between ERK and p38 MAPK. 2017 Aug 2
120 28572744 Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines. 2017 1
121 28629997 Membrane translocation of transient receptor potential ankyrin 1 induced by inflammatory cytokines in lung cancer cells. 2017 Aug 26 2
122 28641719 Surfactant Protein D Inhibits Interleukin-12p40 Production by Macrophages Through the SIRPα/ROCK/ERK Signaling Pathway. 2017 Jun 2
123 28647515 A phytoestrogen supplement prevents the altered gene expression associated with pregnancy implantation induced by IL-1β in endometrial epithelial cells. 2017 Sep 1
124 28726203 Cysteine-Containing Peptides Stimulate Monocyte Migration through NADPH-Oxidase Activation. 2017 Jun 1
125 28791359 Stromal cell-derived factor 1 protects human periodontal ligament stem cells against hydrogen peroxide-induced apoptosis. 2017 Oct 2
126 28842382 Varenicline promotes endothelial cell migration by lowering vascular endothelial-cadherin levels via the activated α7 nicotinic acetylcholine receptor-mitogen activated protein kinase axis. 2017 Sep 1 1
127 28849149 Rab5a is overexpressed in oral cancer and promotes invasion through ERK/MMP signaling. 2017 Oct 1
128 28867541 miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma. 2017 Oct 1
129 28921713 Chebulinic Acid Isolated From the Fruits of Terminalia chebula Specifically Induces Apoptosis in Acute Myeloid Leukemia Cells. 2017 Dec 1
130 28945007 Nonmineralized and Mineralized Collagen Scaffolds Induce Differential Osteogenic Signaling Pathways in Human Mesenchymal Stem Cells. 2017 Dec 2
131 28977593 Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway. 2017 Oct 1 1
132 28983584 Na+/K+‑ATPase DR region‑specific antibody protects U251 cells against hypoxia reperfusion‑induced injury via the PI3K/AKT and ERK pathways. 2017 Dec 1
133 28988530 Hyperexpression of Integrin α5β1 Promotes Resistance of MCF-7 Human Breast Carcinoma Cells to Doxorubicin via ERK Protein Kinase Down-regulation. 2017 Sep 1
134 28990053 P38/ERK MAPK signaling pathways are involved in the regulation of filaggrin and involucrin by IL‑17. 2017 Dec 1
135 29050311 TMEM17 depresses invasion and metastasis in lung cancer cells via ERK signaling pathway. 2017 Sep 19 1
136 29070145 [Effect of ERK1/2 Signaling Pathway Inhibitor PD98059 on the Expression of Ras, BRaf, MEK, ERK1/2 in Marrow Nucleated Red Blood Cells of CMS Patients]. 2017 Oct 1
137 29073620 Activation of ERK and Mutual Regulation of Stat3 and SP1 Contribute to Inhibition of PDK1 Expression by Atractylenolide-1 in Human Lung Cancer Cells. 2017 1
138 29103028 PD98059 impairs the cisplatin-resistance of ovarian cancer cells by suppressing ERK pathway and epithelial mesenchymal transition process. 2017 Dec 12 3
139 29152067 Propoxur enhances MMP-2 expression and the corresponding invasion of human breast cancer cells via the ERK/Nrf2 signaling pathway. 2017 Oct 20 1
140 31966619 Hydroxyapatite nanocrystals stimulate osteogenic differentiation in primary human aortic smooth muscle cells by activation of oxidative stress and the ERK pathway. 2017 1
141 31966844 Inhibitory effect of the mitogen activated protein kinase specific inhibitor PD98059 on Mtb-Ag-activated γδΤ cells. 2017 2
142 25683703 Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells. 2016 May 1
143 26263195 Inhibitory effects of N,N,N-trimethyl phytosphingosine-iodide on melanogenesis via ERK activation-mediated MITF degradation. 2016 1
144 26320741 The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1β transcription and processing in monocytes. 2016 Nov 1
145 26346882 Agmatine Protects Against 6-OHDA-Induced Apoptosis, and ERK and Akt/GSK Disruption in SH-SY5Y Cells. 2016 Aug 1
146 26460784 Activation of ERK pathway is required for 15-HETE-induced angiogenesis in human umbilical vascular endothelial cells. 2016 2
147 26497030 The Ras/Raf/Erk Pathway Mediates the Subarachnoid Hemorrhage-Induced Apoptosis of Hippocampal Neurons Through Phosphorylation of p53. 2016 Oct 1
148 26519986 Mechanism of action of the breast cancer-promoter hormone, 5α-dihydroprogesterone (5αP), involves plasma membrane-associated receptors and MAPK activation. 2016 Jan 1
149 26526982 Modulation of expression of 17-Hydroxylase/17,20 lyase (CYP17) and P450 aromatase (CYP19) by inhibition of MEK1 in a human ovarian granulosa-like tumor cell line. 2016 1
150 26596264 Calcitonin gene-related peptide mediates an inflammatory response in Schwann cells via cAMP-dependent ERK signaling cascade. 2016 Jan 1 1