2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

mitogen-activated protein kinase 1 ; Homo sapiens







132 Article(s)
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51 22509540 [Effect of epidermal growth factor on migration of human amniotic mesenchymal stem cells]. 2011 Dec 1
52 19889638 Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway. 2010 Jan 1 1
53 19956885 Imatinib mesylate (STI571) enhances amrubicin-induced cytotoxic activity through inhibition of the phosphatidylinositol 3-kinase/Akt pathway in small cell lung cancer cells. 2010 Jan 1
54 20336745 Type I collagen promotes proliferation and osteogenesis of human mesenchymal stem cells via activation of ERK and Akt pathways. 2010 Sep 1 3
55 20398401 HAb18G/CD147 cell-cell contacts confer resistance of a HEK293 subpopulation to anoikis in an E-cadherin-dependent manner. 2010 Apr 17 2
56 20664988 PTEN sensitizes MDA-MB-468 cells to inhibition of MEK/Erk signaling for the blockade of cell proliferation. 2010 Sep 1
57 20926971 Leptin and its intracellular signaling pathway maintains the neurosphere. 2010 Dec 29 1
58 21205476 [Cross-talk between PI3K/Akt and MEK/ERK pathways regulates human hepatocellular carcinoma cell cycle progression under endoplasmic reticulum stress]. 2010 Dec 1
59 21209852 Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling. 2010 Dec 30 1
60 19082492 RNAi-mediated downregulation of radiation-induced MMP-9 leads to apoptosis via activation of ERK and Akt in IOMM-Lee cells. 2009 Jan 1
61 19139269 Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells. 2009 Apr 1
62 19223550 LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. 2009 Mar 1 1
63 19380828 HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism. 2009 May 1 1
64 19424594 Cross-talk between PI3K/Akt and MEK/ERK pathways mediates endoplasmic reticulum stress-induced cell cycle progression and cell death in human hepatocellular carcinoma cells. 2009 Jun 1
65 19610136 Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. 2009 Jul 21 1
66 19775474 A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated ERK and Akt activation in endometrial cancer Hec1A cells. 2009 Sep 24 1
67 17949889 Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors. 2008 Jan 1
68 18256541 Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells. 2008 Mar 1 1
69 18468510 Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells. 2008 Jul 18 1
70 18520705 A role for IL-18 in human neutrophil apoptosis. 2008 Dec 1
71 18729215 Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling. 2008 Sep 1
72 18953090 Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons. 2008 Sep 2
73 19077250 Protein kinase Cepsilon is important for migration of neuroblastoma cells. 2008 Dec 11 1
74 17067555 Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. 2007 Jan 15 1
75 17222412 Involvement of phosphatidylinositol-3-kinase and ERK pathways in the production of TGF-beta1 by macrophages treated with liposomes composed of phosphatidylserine. 2007 Jan 23 1
76 17303382 Hypoxia induces apoptosis of HUVECs in an in vitro capillary model by activating proapoptotic signal p38 through suppression of ERK1/2. 2007 Jun 1
77 17473185 Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1 alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells. 2007 May 1 1
78 17581202 Leukotriene B(4) enhances tumour necrosis factor-alpha-induced CCL27 production in human keratinocytes. 2007 Jul 1
79 17643958 Activation of calcium-dependent kinases and epidermal growth factor receptor regulate muscarinic acetylcholine receptor-mediated MAPK/ERK activation in thyroid epithelial cells. 2007 Oct 1
80 17878755 Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha/CXCR4 via PI3K/Akt/eNOS signal transduction pathway. 2007 Sep 1
81 17950696 Hypoxia inhibits the SDF-1-dependent migration of human leukemic cell line HL-60 via blocking of Akt activation. 2007 Dec 14 1
82 16287813 Centaurin-alpha1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases. 2006 Jan 20 1
83 16387404 Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation. 2006 Jun 1
84 16722795 EGF-induced cell migration is mediated by ERK and PI3K/AKT pathways in cultured human lens epithelial cells. 2006 Apr 1
85 16788844 Culture of human cervical cancer cells, SiHa, in the presence of fibronectin activates MMP-2. 2006 Aug 1
86 16914897 P2Y receptors activate MAPK/ERK through a pathway involving PI3K/PDK1/PKC-zeta in human vein endothelial cells. 2006 1
87 16959214 Malignant hematopoietic cells induce an increased expression of VEGFR-1 and VEGFR-3 on bone marrow endothelial cells via AKT and mTOR signalling pathways. 2006 Oct 27 1
88 17341207 Culture of human fibrosarcoma HT-1080 cells in presence of fibronectin activates MMP-2. 2006 1
89 15607817 Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase. 2005 Mar 1
90 15744749 Activation of MAP kinase by muscarinic cholinergic receptors induces cell proliferation and protein synthesis in human breast cancer cells. 2005 Aug 1
91 15791648 Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers. 2005 May 1
92 15850772 Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. 2005 Jun 3 1
93 15857748 Effects of FSH and 17beta-estradiol on the transactivation of estrogen-regulated promoters and cell proliferation in L cells. 2005 Mar 1
94 15934945 NT3 inhibits FGF2-induced neural progenitor cell proliferation via the PI3K/GSK3 pathway. 2005 Jun 1
95 16164642 VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells. 2005 Oct 2
96 16211241 Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death. 2005 Nov 1
97 16211242 Effects of MEK1 and PI3K inhibitors on allyl-, benzyl- and phenylethyl-isothiocyanate-induced G2/M arrest and cell death in Caco-2 cells. 2005 Nov 1
98 15144225 Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway. 2004 May 1
99 15147515 Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells. 2004 Jun 1
100 15177934 Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells. 2004 Aug 15 1