2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

mitogen-activated protein kinase 1 ; Homo sapiens







132 Article(s)
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1 35100937 2-(Naphthalene-2-thio)-5,8-dimethoxy-1,4-naphthoquinone induces apoptosis via ROS-mediated MAPK, AKT, and STAT3 signaling pathways in HepG2 human hepatocellular carcinoma cells. 2022 Jan 1
2 35164673 Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma. 2022 Feb 14 1
3 33290316 A PI3K inhibitor-induced growth inhibition of cancer cells is linked to MEK-ERK pathway. 2021 Jun 1 2
4 33505496 Effect and Molecular Mechanisms of Jiedu Recipe on Hypoxia-Induced Angiogenesis after Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma. 2021 1
5 35111045 An ApoA-I Mimic Peptide of 4F Promotes SDF-1α Expression in Endothelial Cells Through PI3K/Akt/ERK/HIF-1α Signaling Pathway. 2021 2
6 31894254 Anti‑platelet activity of mineral‑balanced deep sea water is mediated via the regulation of Akt and ERK pathway crosstalk. 2020 Feb 1
7 32393432 Connective tissue growth factor (CCN2) inhibits TNF-α-induced apoptosis by enhancing autophagy through the Akt and Erk pathways in osteoblasts. 2020 May 1 1
8 32553076 Dexmedetomidine Attenuates High Glucose-induced HK-2 Epithelial-mesenchymal Transition by Inhibiting AKT and ERK. 2020 May 20 1
9 31034822 Nitric oxide: Is it the culprit for the continued expansion of keloids? 2019 Jul 5 1
10 31076999 Naringenin Inhibit the Hydrogen Peroxide-Induced SH-SY5Y Cells Injury Through Nrf2/HO-1 Pathway. 2019 Nov 1
11 31270642 Decellularized and solubilized pancreatic stroma promotes the in vitro proliferation, migration and differentiation of BMSCs into IPCs. 2019 Sep 1
12 31348616 Chemokine receptor 7 targets the vascular endothelial growth factor via the AKT/ERK pathway to regulate angiogenesis in colon cancer. 2019 Sep 1
13 31534465 Dracohodin Perochlorate Stimulates Fibroblast Proliferation via EGFR Activation and Downstream ERK/CREB and PI3K/Akt/mTOR Pathways In Vitro. 2019 1
14 31807174 Tanshinone IIA reverses EGF- and TGF-β1-mediated epithelial-mesenchymal transition in HepG2 cells via the PI3K/Akt/ERK signaling pathway. 2019 Dec 1
15 29207091 Fibroblast activation protein-α in tumor cells promotes colorectal cancer angiogenesis via the Akt and ERK signaling pathways. 2018 Feb 1
16 29524295 MICAL1 facilitates breast cancer cell proliferation via ROS-sensitive ERK/cyclin D pathway. 2018 Jun 1
17 29913144 Paraquat toxicity is attenuated by 4-phenylbutyrate-induced phosphorylation of ERK2 via PI3K in A549 cells. 2018 Sep 5 1
18 30622592 Neuroprotective Effects of Gagam-Sipjeondaebo-Tang, a Novel Herbal Formula, against MPTP-Induced Parkinsonian Mice and MPP+-Induced Cell Death in SH-SY5Y Cells. 2018 1
19 28461772 PI3K and ERK signaling pathways are involved in differentiation of monocytic cells induced by 27-hydroxycholesterol. 2017 May 1
20 26808296 Helicobacter pylori induces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3β in human gastric cancer cells. 2016 Dec 1
21 26919896 The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells. 2016 May 1 1
22 26934554 VEGF promotes gastric cancer development by upregulating CRMP4. 2016 Mar 29 1
23 27035160 Salinomycin causes migration and invasion of human fibrosarcoma cells by inducing MMP-2 expression via PI3-kinase, ERK-1/2 and p38 kinase pathways. 2016 Jun 1
24 27240591 S100A16 promotes cell proliferation and metastasis via AKT and ERK cell signaling pathways in human prostate cancer. 2016 Sep 1
25 27641443 Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes. 2016 Oct 2
26 27802437 Valproic Acid Promotes Human Glioma U87 Cells Apoptosis and Inhibits Glycogen Synthase Kinase-3β Through ERK/Akt Signaling. 2016 1
27 27806094 EGF-Induced VEGF Exerts a PI3K-Dependent Positive Feedback on ERK and AKT through VEGFR2 in Hematological In Vitro Models. 2016 1
28 25638063 Octacosanol enhances the proliferation and migration of human umbilical vein endothelial cells via activation of the PI3K/Akt and MAPK/Erk pathways. 2015 Mar 1
29 25638174 Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer. 2015 Feb 1 1
30 25663277 Involvement of nucleotides in glial growth following scratch injury in avian retinal cell monolayer cultures. 2015 Jun 1
31 25701261 Insulin priming effect on estradiol-induced breast cancer metabolism and growth. 2015 1
32 25748730 Paeoniflorin diminishes ConA-induced IL-8 production in primary human hepatic sinusoidal endothelial cells in the involvement of ERK1/2 and Akt phosphorylation. 2015 May 1
33 26075254 Deguelin induces apoptosis by targeting both EGFR-Akt and IGF1R-Akt pathways in head and neck squamous cell cancer cell lines. 2015 1
34 26302186 Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury. 2015 Nov 1
35 26347199 A bioinformatic and mechanistic study elicits the antifibrotic effect of ursolic acid through the attenuation of oxidative stress with the involvement of ERK, PI3K/Akt, and p38 MAPK signaling pathways in human hepatic stellate cells and rat liver. 2015 1
36 24206109 Stimulating ERK/PI3K/NFκB signaling pathways upon activation of mGluR2/3 restores OGD-induced impairment in glutamate clearance in astrocytes. 2014 Jan 1
37 22716951 Maslinic acid inhibits the metastatic capacity of DU145 human prostate cancer cells: possible mediation via hypoxia-inducible factor-1α signalling. 2013 Jan 28 2
38 23142153 Retinoic acid protects against proteasome inhibition associated cell death in SH-SY5Y cells via the AKT pathway. 2013 Jan 1
39 23233127 Knockdown of integrin α3β1 expression induces proliferation and migration of non-small cell lung cancer cells. 2013 Feb 1
40 23469688 8-(Tosylamino)quinoline inhibits tumour progression through targeting phosphoinositide-3-kinase/Akt pathway. 2013 Feb 1
41 23948751 Reversal of boswellic acid analog BA145 induced caspase dependent apoptosis by PI3K inhibitor LY294002 and MEK inhibitor PD98059. 2013 Dec 1
42 23951091 Angiogenic properties of human dental pulp stem cells. 2013 1
43 24227918 Apelin-13 induces proliferation, migration, and collagen I mRNA expression in human RPE cells via PI3K/Akt and MEK/Erk signaling pathways. 2013 1
44 22441145 Transforming growth factor β and Ras/MEK/ERK signaling regulate the expression level of a novel tumor suppressor Lefty. 2012 Jul 1
45 22509106 NGF promotes cell cycle progression by regulating D-type cyclins via PI3K/Akt and MAPK/Erk activation in human corneal epithelial cells. 2012 1
46 22716253 Anti-ageing effects of alpha-naphthoflavone on normal and UVB-irradiated human skin fibroblasts. 2012 Jul 1
47 22879882 PI3K contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs. 2012 1
48 23185517 Anti-myeloma activity of Akt inhibition is linked to the activation status of PI3K/Akt and MEK/ERK pathway. 2012 1
49 20857402 Homocysteine induces smooth muscle cell proliferation through differential regulation of cyclins A and D1 expression. 2011 Apr 2
50 21544242 MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1α expression. 2011 Apr 22 1