Paclitaxel

mitogen-activated protein kinase 1 ; Homo sapiens







82 Article(s)
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51 17390065 The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis. 2007 May 11
52 16051289 Enhancement of esculetin on Taxol-induced apoptosis in human hepatoma HepG2 cells. 2006 Jan 1 1
53 16395709 p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis. 2006 Jun 15 2
54 16397234 Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt. 2006 Jan 1 3
55 16515784 ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistance. 2006 May 15 4
56 16721826 Different signaling responses to anti-proliferative agents in human aortic and venous smooth muscle cells. 2006 Oct 15 2
57 16969513 Paclitaxel and ceramide synergistically induce cell death with transient activation of EGFR and ERK pathway in pancreatic cancer cells. 2006 Oct 4
58 15592521 A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway. 2005 Jan 27 1
59 15657900 Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity. 2005 May 20 2
60 15778245 MAP kinases in lung endothelial permeability induced by microtubule disassembly. 2005 Jul 2
61 15805287 Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants. 2005 Apr 1 1
62 15870880 Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells. 2005 Jun 1
63 16101130 Biomarkers of anticancer activity of R115777 (Tipifarnib, Zarnestra) in human breast cancer models in vitro. 2005 Sep-Oct 2
64 16211241 Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death. 2005 Nov 5
65 15241487 MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. 2004 Jul 8 1
66 12691824 Down-regulation of Raf-1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells. 2003 Apr 10 2
67 12087097 Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel. 2002 Sep 6 3
68 12121974 Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. 2002 Sep 20 1
69 12181740 Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants. 2002 Sep 1
70 11170175 Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells. 2001 Feb 1 2
71 11245462 Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells. 2001 Feb 15 1
72 11278851 Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machinery. 2001 Jun 1 4
73 11313944 Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. 2001 Jan 11 4
74 11455016 Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines. 2001 Aug 6
75 11461121 The role of ERK 1/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells. 2001 Aug 1 6
76 11720482 Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells. 2001 Nov 2 5
77 10623471 Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells. 2000 Jan 10 2
78 11038347 MEK inhibition enhances paclitaxel-induced tumor apoptosis. 2000 Dec 15 2
79 9927194 Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells. 1999 Jan 14 1
80 10097113 Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis. 1999 Mar 30 1
81 9443400 Transient stimulation of the c-Jun-NH2-terminal kinase/activator protein 1 pathway and inhibition of extracellular signal-regulated kinase are early effects in paclitaxel-mediated apoptosis in human B lymphoblasts. 1998 Jan 15 3
82 9774447 Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK). 1998 Oct 23 2