| 1 |
34987637 | A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects. | 2022 |
1 |
| 2 |
35063772 | Identification of a novel target site for ATP-independent ERK2 inhibitors. | 2022 Feb 19 |
1 |
| 3 |
35074408 | The effect of P2X7R- mediated Ca2+ and MAPK signaling in OPG-induced duck embryo osteoclasts differentiation and adhesive structure damage. | 2022 Mar 15 |
1 |
| 4 |
35439648 | Quantitative phosphoproteomics reveals ectopic ATP synthase on mesenchymal stem cells to promote tumor progression via ERK/c-Fos pathway activation. | 2022 Apr 18 |
2 |
| 5 |
35566048 | The Inhibition of Gastric Cancer Cells' Progression by 23,24-Dihydrocucurbitacin E through Disruption of the Ras/Raf/ERK/MMP9 Signaling Pathway. | 2022 Apr 22 |
1 |
| 6 |
33290316 | A PI3K inhibitor-induced growth inhibition of cancer cells is linked to MEK-ERK pathway. | 2021 Jun 1 |
1 |
| 7 |
33655414 | Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8. | 2021 Aug |
1 |
| 8 |
34020277 | Synthesis, biological evaluation and molecular docking studies of novel 1,2,3-triazole-quinazolines as antiproliferative agents displaying ERK inhibitory activity. | 2021 Aug |
2 |
| 9 |
34507982 | Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade. | 2021 Sep 14 |
1 |
| 10 |
34583590 | Structure based designing of thiazolidinone-pyrimidine derivatives as ERK2 inhibitors: Synthesis and in vitro evaluation. | 2021 Oct |
1 |
| 11 |
34833046 | Extracellular ATP Induced S-Phase Cell Cycle Arrest via P2Y Receptor-Activated ERK Signaling in Poorly Differentiated Oral Squamous Cell Carcinoma SAS Cells. | 2021 Nov 2 |
4 |
| 12 |
31744895 | ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine. | 2020 Feb |
1 |
| 13 |
31965713 | Resveratrol Derivative, Trans-3, 5, 4'-Trimethoxystilbene, Prevents the Developing of Atherosclerotic Lesions and Attenuates Cholesterol Accumulation in Macrophage Foam Cells. | 2020 Mar |
1 |
| 14 |
32545311 | Calcium Entry through TRPV1: A Potential Target for the Regulation of Proliferation and Apoptosis in Cancerous and Healthy Cells. | 2020 Jun 11 |
1 |
| 15 |
30396063 | Design, synthesis and biological evaluation of fused naphthofuro[3,2-c] quinoline-6,7,12-triones and pyrano[3,2-c]quinoline-6,7,8,13-tetraones derivatives as ERK inhibitors with efficacy in BRAF-mutant melanoma. | 2019 Feb |
2 |
| 16 |
31022583 | Cucurbitacins inspired organic synthesis: Potential dual inhibitors targeting EGFR - MAPK pathway. | 2019 Jul 1 |
1 |
| 17 |
31058487 | A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. | 2019 Jun 21 |
2 |
| 18 |
31311868 | Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2. | 2019 Jul 30 |
1 |
| 19 |
31745079 | Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo. | 2019 Nov 19 |
1 |
| 20 |
28030988 | Functional roles of magnesium binding to extracellular signal-regulated kinase 2 explored by molecular dynamics simulations and principal component analysis. | 2018 Feb |
2 |
| 21 |
29259132 | Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity. | 2018 Feb 9 |
4 |
| 22 |
29510947 | A combination of 19F NMR and surface plasmon resonance for site-specific hit selection and validation of fragment molecules that bind to the ATP-binding site of a kinase. | 2018 May 1 |
2 |
| 23 |
29760222 | ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy. | 2018 Aug 15 |
2 |
| 24 |
30019396 | Nanocatalyst Complex Can Dephosphorylate Key Proteins in MAPK Pathway for Cancer Therapy. | 2018 Sep |
3 |
| 25 |
30268050 | Synthesis of novel 1,2-bis-quinolinyl-1,4-naphthoquinones: ERK2 inhibition, cytotoxicity and molecular docking studies. | 2018 Dec |
2 |
| 26 |
26961545 | CD40 Negatively Regulates ATP-TLR4-Activated Inflammasome in Microglia. | 2017 Mar |
1 |
| 27 |
28740606 | Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. | 2017 Jul 13 |
1 |
| 28 |
27633746 | Enrichment of Metabolite-Binding Proteins by Affinity Elution in Tandem Hydrophobic Interaction Chromatography (AETHIC) Reveals RKIP Regulating ERK Signaling in an ATP-Dependent Manner. | 2016 Oct 7 |
2 |
| 29 |
27905300 | Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP. | 2016 Nov |
1 |
| 30 |
28024406 | The Effect of Conformational Flexibility on Binding Free Energy Estimation between Kinases and Their Inhibitors. | 2016 Dec 27 |
1 |
| 31 |
25183652 | Adenosine triphosphate prevents serum deprivation-induced apoptosis in human mesenchymal stem cells via activation of the MAPK signaling pathways. | 2015 Jan |
2 |
| 32 |
25485998 | Effects of hyperoxic exposure on signal transduction pathways in the lung. | 2015 Apr |
2 |
| 33 |
25884645 | Preclinical analysis of the anti-tumor and anti-metastatic effects of Raf265 on colon cancer cells and CD26(+) cancer stem cells in colorectal carcinoma. | 2015 Apr 11 |
1 |
| 34 |
26305625 | Coxsackievirus B3 induces autophagy in HeLa cells via the AMPK/MEK/ERK and Ras/Raf/MEK/ERK signaling pathways. | 2015 Dec |
1 |
| 35 |
23798356 | Gravity loading induces adenosine triphosphate release and phosphorylation of extracellular signal-regulated kinases in human periodontal ligament cells. | 2014 Nov |
2 |
| 36 |
24031026 | Targeting of magnolin on ERKs inhibits Ras/ERKs/RSK2-signaling-mediated neoplastic cell transformation. | 2014 Feb |
1 |
| 37 |
24704509 | Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases. | 2014 May 22 |
4 |
| 38 |
24856138 | Modulating noncatalytic function with kinase inhibitors. | 2014 May 22 |
2 |
| 39 |
25118288 | Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation. | 2014 Sep 26 |
2 |
| 40 |
23224888 | Calcium influx through reversed NCX controls migration of microglia. | 2013 |
2 |
| 41 |
23410953 | Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. | 2013 Jun |
1 |
| 42 |
23647195 | Diethylmaleate and iodoacetate in combination caused profound cell death in astrocytes. | 2013 Oct |
1 |
| 43 |
23685672 | Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. | 2013 Jul |
1 |
| 44 |
23847348 | ERK pathway inhibitors: how low should we go? | 2013 Jul |
2 |
| 45 |
23935097 | A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor. | 2013 Sep 27 |
1 |
| 46 |
22615491 | Mitogen-activated protein kinase phosphorylation of splicing factor 45 (SPF45) regulates SPF45 alternative splicing site utilization, proliferation, and cell adhesion. | 2012 Jul |
3 |
| 47 |
22828512 | Extracellular ATP attenuates ischemia-induced caspase-3 cleavage in human endothelial cells. | 2012 Aug 24 |
2 |
| 48 |
22830536 | Docking simulation study and kinase selectivity of f152A1 and its analogs. | 2012 Aug 27 |
1 |
| 49 |
22892241 | The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. | 2012 Sep 1 |
1 |
| 50 |
22982122 | Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents. | 2012 Oct |
1 |