Metformin

mitogen-activated protein kinase 1 ; Homo sapiens







54 Article(s)
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1 32951587 The Chemosensitizing Role of Metformin in Anti-Cancer Therapy. 2021 1
2 33524789 The effects of metformin on autophagy. 2021 May 2
3 33652909 Metformin Increases Survival in Hypopharyngeal Cancer Patients with Diabetes Mellitus: Retrospective Cohort Study and Cell-Based Analysis. 2021 Feb 26 1
4 33788730 Effect of Metformin in Combination With Trametinib and Paclitaxel on Cell Survival and Metastasis in Melanoma Cells. 2021 Mar 3
5 34078517 Effects of different concentrations of metformin on osteoclast differentiation and apoptosis and its mechanism. 2021 Jun 1 6
6 34716862 Synergistic effect of metformin and vemurufenib (PLX4032) as a molecular targeted therapy in anaplastic thyroid cancer: an in vitro study. 2021 Nov 1
7 34944598 Metformin Improves Stemness of Human Adipose-Derived Stem Cells by Downmodulation of Mechanistic Target of Rapamycin (mTOR) and Extracellular Signal-Regulated Kinase (ERK) Signaling. 2021 Nov 27 4
8 31789625 Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells. 2020 Apr 1
9 32248666 Metformin revert insulin-induced oxaliplatin resistance by activating mitochondrial apoptosis pathway in human colon cancer HCT116 cells. 2020 Jun 2
10 32734128 Antitumor Activity of Combination Therapy with Metformin and Trametinib in Non-Small Cell Lung Cancer Cells. 2020 Jun 9
11 33014814 Metformin Overcomes Acquired Resistance to EGFR TKIs in EGFR-Mutant Lung Cancer via AMPK/ERK/NF-κB Signaling Pathway. 2020 2
12 33126710 Different Effects of Metformin and A769662 on Sodium Iodate-Induced Cytotoxicity in Retinal Pigment Epithelial Cells: Distinct Actions on Mitochondrial Fission and Respiration. 2020 Oct 28 1
13 33489797 Metformin reverses chemoresistance in non-small cell lung cancer via accelerating ubiquitination-mediated degradation of Nrf2. 2020 Dec 1
14 30153063 Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model. 2019 Jan 1 1
15 30551411 Metformin inhibits estradiol and progesterone-induced decidualization of endometrial stromal cells by regulating expression of progesterone receptor, cytokines and matrix metalloproteinases. 2019 Jan 2
16 30551515 Metformin increases antitumor activity of MEK inhibitor binimetinib in 2D and 3D models of human metastatic melanoma cells. 2019 Jan 1
17 31321352 Synergistic Enhancement of Paclitaxel-induced Inhibition of Cell Growth by Metformin in Melanoma Cells. 2019 Jun 2
18 31348945 Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. 2019 Sep 15 3
19 31886264 Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes. 2019 2
20 29285650 Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells. 2018 Feb 1
21 29351188 Proangiogenic Effect of Metformin in Endothelial Cells Is via Upregulation of VEGFR1/2 and Their Signaling under Hyperglycemia-Hypoxia. 2018 Jan 19 1
22 29467552 Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase. 2018 Feb 21 2
23 29630425 Suppressive effects of metformin on T-helper 1-related chemokines expression in the human monocytic leukemia cell line THP-1. 2018 Nov 4
24 29760016 Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1. 2018 Jul 20 1
25 30023463 Combination of BEZ235 and Metformin Has Synergistic Effect on Cell Viability in Colorectal Cancer Cells. 2018 Jun 2
26 30333878 Metformin reverses the resistance mechanism of lung adenocarcinoma cells that knocks down the Nrf2 gene. 2018 Nov 3
27 27699813 FOXO3a Expression Regulated by ERK Signaling is Inversely Correlated With Y-Box Binding Protein-1 Expression in Prostate Cancer. 2017 Feb 1
28 28230206 MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway. 2017 Feb 23 1
29 28335557 ROS Production and ERK Activity Are Involved in the Effects of d-β-Hydroxybutyrate and Metformin in a Glucose Deficient Condition. 2017 Mar 21 2
30 28927780 Effects of metformin on proliferation and apoptosis of human megakaryoblastic Dami and MEG-01 cells. 2017 Sep 2
31 26695692 Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma. 2016 3
32 26802022 High efficacy of intravesical treatment of metformin on bladder cancer in preclinical model. 2016 Feb 23 2
33 27424158 Exenatide and metformin express their anti-inflammatory effects on human monocytes/macrophages by the attenuation of MAPKs and NFκB signaling. 2016 Oct 2
34 25846811 Negative regulation of the LKB1/AMPK pathway by ERK in human acute myeloid leukemia cells. 2015 Jul 5
35 26052399 Prevention of hepatocellular carcinoma by correction of metabolic abnormalities: Role of statins and metformin. 2015 May 18 1
36 26186064 The antileukemia effect of metformin in the Philadelphia chromosome-positive leukemia cell line and patient primary leukemia cell. 2015 Oct 1
37 26391180 Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling. 2015 Sep 22 1
38 24446492 Repositioning therapy for thyroid cancer: new insights on established medications. 2014 Jun 1
39 24480115 Metformin modulates PI3K and GLUT4 expression and Akt/PKB phosphorylation in human endometrial stromal cells after stimulation with androgen and insulin. 2014 Apr 1
40 24788596 Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines. 2014 Jun 1
41 25245054 Metformin inhibits the invasion of human hepatocellular carcinoma cells and enhances the chemosensitivity to sorafenib through a downregulation of the ERK/JNK-mediated NF-κB-dependent pathway that reduces uPA and MMP-9 expression. 2014 Dec 2
42 25493642 Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells. 2014 1
43 23462329 Metformin inhibits the growth of human pancreatic cancer xenografts. 2013 Jul 1
44 23607966 mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. 2013 Jul 1
45 23707609 Metformin inhibits heme oxygenase-1 expression in cancer cells through inactivation of Raf-ERK-Nrf2 signaling and AMPK-independent pathways. 2013 Sep 1 3
46 23879009 [Metformin--new treatment strategies for gynecologic neoplasms]. 2013 1
47 21995500 Inhibition of p42 MAPK using a nonviral vector-delivered siRNA potentiates the anti-tumor effect of metformin in prostate cancer cells. 2012 Apr 3
48 22575507 Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway. 2012 Jun 8 4
49 23257425 [Effect of metformin on acute promyelocytic leukemia cell line NB4 and its mechanism]. 2012 Dec 1
50 21619869 AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells. 2011 Jun 17 4