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32390005 | Compensatory combination of romidepsin with gemcitabine and cisplatin to effectively and safely control urothelial carcinoma. | 2020 Jul |
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32709140 | Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells. | 2020 Jul 17 |
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29958141 | Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death. | 2018 Oct |
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27829272 | Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes. | 2017 Jul 1 |
2 |
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26716417 | Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells. | 2016 Feb 2 |
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26878775 | Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia. | 2016 May |
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27941930 | ERK-mediated NF-κB activation through ASIC1 in response to acidosis. | 2016 Dec 12 |
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24111577 | Deferoxamine promotes osteoblastic differentiation in human periodontal ligament cells via the nuclear factor erythroid 2-related factor-mediated antioxidant signaling pathway. | 2014 Oct |
2 |
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24307199 | Regulation of death induction and chemosensitizing action of 3-bromopyruvate in myeloid leukemia cells: energy depletion, oxidative stress, and protein kinase activity modulation. | 2014 Feb |
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25201354 | Induction of glutathione synthesis in human hepatocytes by acute and chronic arsenic exposure: differential roles of mitogen-activated protein kinases. | 2014 Nov 5 |
3 |
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23647195 | Diethylmaleate and iodoacetate in combination caused profound cell death in astrocytes. | 2013 Oct |
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23837948 | Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway. | 2013 Dec |
2 |
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24040019 | Synergistic apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway. | 2013 |
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21523454 | Assessment of the involvement of oxidative stress and Mitogen-Activated Protein Kinase signaling pathways in the cytotoxic effects of arsenic trioxide and its combination with sulindac or its metabolites: sulindac sulfide and sulindac sulfone on human leukemic cell lines. | 2012 Jun |
2 |
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22246135 | Flavonoid baicalein modulates H2O2-induced mitogen-activated protein kinases activation and cell death in SK-N-MC cells. | 2012 May |
2 |
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22508521 | XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells. | 2012 Jul |
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20473523 | Differential induction of reactive oxygen species through Erk1/2 and Nox-1 by FK228 for selective apoptosis of oncogenic H-Ras-expressing human urinary bladder cancer J82 cells. | 2011 Mar |
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21166414 | The effects of mitogen-activated protein kinase inhibitors or small interfering RNAs on gallic acid-induced HeLa cell death in relation to reactive oxygen species and glutathione. | 2011 Jan 26 |
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19622586 | EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation. | 2009 Aug 1 |
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18048013 | Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons. | 2008 Jan 16 |
6 |
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19276532 | Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation. | 2008 |
3 |
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17707924 | Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells. | 2007 Nov |
1 |
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17761302 | The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin. | 2007 Oct 1 |
2 |
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17920036 | Regulation of p21Waf1 expression and TNFalpha biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: involvement of JNK and ERK pathways. | 2007 Nov 30 |
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16972261 | Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis. | 2006 Dec |
4 |
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15843040 | Pharmacological inhibitors of extracellular signal-regulated protein kinases attenuate the apoptotic action of cisplatin in human myeloid leukemia cells via glutathione-independent reduction in intracellular drug accumulation. | 2005 Apr 15 |
1 |
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16357186 | Glutathione-related systems and modulation of extracellular signal-regulated kinases are involved in the resistance of AGS adenocarcinoma gastric cells to diallyl disulfide-induced apoptosis. | 2005 Dec 15 |
2 |
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14610070 | 12-O-tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells. Regulation by extracellular signal-regulated protein kinases and glutathione. | 2004 Jan 30 |
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15530848 | Reactive oxygen species mediate RANK signaling in osteoclasts. | 2004 Dec 10 |
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14697665 | Selective and persistent activation of extracellular signal-regulated protein kinase by nitric oxide in glial cells induces neuronal degeneration in glutathione-depleted midbrain cultures. | 2003 Dec |
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12083801 | Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. | 2002 Jul 15 |
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11522656 | Activation of extracellular signal-regulated kinase and c-Jun-NH(2)-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells. | 2001 Sep 1 |
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11532983 | Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability. | 2001 Aug 15 |
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11768769 | Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). | 2001 Aug-Nov |
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12671299 | Differential activation of MAPK and ICE/Ced-3 protease in chemical-induced apoptosis. The role of oxidative stress in the regulation of mitogen-activated protein kinases (MAPKs) leading to gene expression and survival or activation of caspases leading to apoptosis. | 1998 Jun |
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9360968 | Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants. | 1997 Nov 14 |
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