Doxorubicin

mitogen-activated protein kinase 1 ; Homo sapiens







79 Article(s)
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51 21300134 Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma. 2011 May 1
52 21790999 Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib--the role of extracellular signal-regulated kinase counteraction. 2011 Sep 3
53 21854868 Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway. 2011 Dec 3
54 21869603 Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. 2011 Sep 1 2
55 21881167 Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells. 2011 Aug 1
56 20428768 Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast cancer cells. 2010 Jun 3
57 21159167 Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin. 2010 Dec 15 1
58 21472291 Activation of the PI3K/Akt and MAPK signaling pathways antagonizes adriamycin-induced HL-60 leukemia cell apoptosis. 2010 Jul-Aug 1
59 19223549 cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation. 2009 Mar 1 1
60 19417026 Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin. 2009 May 15 2
61 18256541 Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells. 2008 Mar 1 1
62 18468633 The effect of doxorubicin on MEK-ERK signaling predicts its efficacy in HCC. 2008 Dec 3
63 18974122 A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. 2008 Nov 1 1
64 17658517 Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity. 2007 Aug 7 1
65 16269455 Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure. 2006 Feb 1
66 16428504 Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death. 2006 Jan 15 1
67 17384286 Superoxide anions are involved in doxorubicin-induced ERK activation in hepatocyte cultures. 2006 Dec 2
68 15870880 Modulation of Raf/MEK/ERK kinase activity does not affect the chemoresistance profile of advanced prostate cancer cells. 2005 Jun 1
69 16059641 Flavonoid quercetin, but not apigenin or luteolin, induced apoptosis in human myeloid leukemia cells and their resistant variants. 2005 1
70 14755690 Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells. 2004 Feb 15 2
71 15116093 Phosphorylation of p53 on Thr55 by ERK2 is necessary for doxorubicin-induced p53 activation and cell death. 2004 Apr 29 5
72 15494689 Signal transduction pathways in Burkitt's lymphoma cell lines BL41 and DG75 with different sensitivity to doxorubicin. 2004 Sep 5
73 12883037 Inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase enhances chemotherapeutic effects on H460 human non-small cell lung cancer cells through activation of apoptosis. 2003 Jul 2
74 12907245 The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. 2003 Aug 1 2
75 11996883 Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF kappa B activation. 2002 Apr 15 2
76 12394272 Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. 2002 Sep 2
77 11170175 Hyperphosphorylation of tau is mediated by ERK activation during anticancer drug-induced apoptosis in neuroblastoma cells. 2001 Feb 1 1
78 11409876 Nuclear extracellular signal-regulated kinase 2 phosphorylates p53 at Thr55 in response to doxorubicin. 2001 Jun 22 2
79 8913269 Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis. 1996 Oct 1 1