Threonine

mitogen-activated protein kinase 1 ; Homo sapiens







163 Article(s)
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1 34046359 Recurrent Somatic MAP2K1 Mutations in Papillary Thyroid Cancer and Colorectal Cancer. 2021 1
2 32782566 ERK-mediated negative feedback regulation of oncogenic EGFRvIII in glioblastoma cells. 2020 Sep 2
3 33073187 Role of the Helix-8 and C-Terminal Tail in Regulating Proteinase Activated Receptor 2 Signaling. 2020 Oct 9 1
4 33133138 Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth. 2020 1
5 30832204 Non-Mammalian Prdx6 Enzymes (Proteins with 1-Cys Prdx Mechanism) Display PLA₂ Activity Similar to the Human Orthologue. 2019 Mar 1 1
6 30835471 Role of Conserved Histidine and Serine in the HCXXXXXRS Motif of Human Dual-Specificity Phosphatase 5. 2019 Apr 22 1
7 31052520 How to Steer and Control ERK and the ERK Signaling Cascade Exemplified by Looking at Cardiac Insufficiency. 2019 May 2 2
8 31053301 Negative feedback regulation of ErbB4 tyrosine kinase activity by ERK-mediated non-canonical phosphorylation. 2019 Jun 25 1
9 31118072 Regulation of cisplatin-resistant head and neck squamous cell carcinoma by the SRC/ETS-1 signaling pathway. 2019 May 22 1
10 31320475 ERK-dependent proteasome degradation of Txnip regulates thioredoxin oxidoreductase activity. 2019 Sep 6 1
11 31358736 SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis. 2019 Jul 29 2
12 29052270 Crystal structure of the human dual specificity phosphatase 1 catalytic domain. 2018 Feb 1
13 29208567 Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells. 2018 Jan 3
14 29289806 Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects. 2018 Feb 1
15 29380370 Endothelial immune activation programmes cell-fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4-ERK-FOXC2 signalling. 2018 Apr 15 1
16 29434871 Mechanisms for DNA-damaging agent-induced inactivation of ErbB2 and ErbB3 via the ERK and p38 signaling pathways. 2018 Feb 5
17 27924560 Assaying Activation and Subcellular Localization of ERK in Cells and Tissues. 2017 1
18 27956712 Induction of Integrin Signaling by Steroid Sulfatase in Human Cervical Cancer Cells. 2017 May 1 3
19 28393288 Differential effects of p38 MAP kinase inhibitors SB203580 and SB202190 on growth and migration of human MDA-MB-231 cancer cell line. 2017 Aug 1
20 28653224 Acquisition of anoikis resistance promotes alterations in the Ras/ERK and PI3K/Akt signaling pathways and matrix remodeling in endothelial cells. 2017 Sep 1
21 28716524 The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation. 2017 Sep 28 1
22 28716922 Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2. 2017 Aug 1 1
23 29084846 The human transient receptor potential vanilloid 3 channel is sensitized via the ERK pathway. 2017 Dec 22 2
24 25915848 Paxillin confers resistance to tyrosine kinase inhibitors in EGFR-mutant lung cancers via modulating BIM and Mcl-1 protein stability. 2016 Feb 4 2
25 26838549 Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation. 2016 Feb 2 1
26 26868487 Phosphorylation Regulates Functions of ZEB1 Transcription Factor. 2016 Oct 2
27 26950759 Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding. 2016 Mar 29 2
28 27422819 Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3. 2016 Sep 9 2
29 27489110 Identification of NEK3 Kinase Threonine 165 as a Novel Regulatory Phosphorylation Site That Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration. 2016 Oct 7 1
30 27793200 Subcellular localisation of pMEK has a different prognosis in locally advanced head and neck cancer treated with concomitant radiochemotherapy. 2016 Oct 28 1
31 25701783 Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells. 2015 Mar 20 1
32 26031292 Activation of the PI3K/Akt/mTOR and MAPK Signaling Pathways in Response to Acute Solar-Simulated Light Exposure of Human Skin. 2015 Aug 1
33 26054059 Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2. 2015 Jun 8 1
34 26080397 Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68. 2015 Jun 30 1
35 26235103 Detection and Differentiation of Threonine- and Tyrosine-Monophosphorylated Forms of ERK1/2 by Capillary Isoelectric Focusing-Immunoassay. 2015 Aug 3 1
36 24627490 Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK. 2014 May 2 1
37 24844603 Extracellular signal-regulated protein kinases 1 and 2 activation by addictive drugs: a signal toward pathological adaptation. 2014 Dec 15 1
38 24982422 The unfolded protein response and the phosphorylations of activating transcription factor 2 in the trans-activation of il23a promoter produced by β-glucans. 2014 Aug 15 3
39 25353341 Phosphorylation of sterol regulatory element-binding protein (SREBP)-1c by p38 kinases, ERK and JNK influences lipid metabolism and the secretome of human liver cell line HepG2. 2014 Dec 1
40 23528948 A quantitative model of ERK MAP kinase phosphorylation in crowded media. 2013 1
41 23575685 Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK. 2013 1
42 23744074 Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascade. 2013 Aug 9 1
43 23822636 Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation. 2013 Oct 3
44 24008236 Endothelial nitric oxide synthase phosphorylation at Threonine 495 and mitochondrial reactive oxygen species formation in response to a high H₂O₂ concentration. 2013 1
45 24043306 Phosphorylation of Rac1 T108 by extracellular signal-regulated kinase in response to epidermal growth factor: a novel mechanism to regulate Rac1 function. 2013 Nov 1
46 21933022 Transcriptional repression of Mad-Max complex by human umbilical cord blood stem cells downregulates extracellular signal-regulated kinase in glioblastoma. 2012 Jul 1 1
47 22121028 Phos-tag SDS-PAGE systems for phosphorylation profiling of proteins with a wide range of molecular masses under neutral pH conditions. 2012 Jan 1
48 22235371 Extracellular Signal-Regulated Kinase (ERK) Activation and Mitogen-Activated Protein Kinase Phosphatase 1 Induction by Pulsatile Gonadotropin-Releasing Hormone in Pituitary Gonadotrophs. 2012 4
49 22260695 ERK phosphorylation and nuclear accumulation: insights from single-cell imaging. 2012 Feb 2
50 22586091 Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells. 2012 May 29 1