Melatonin

mitogen-activated protein kinase 1 ; Homo sapiens







54 Article(s)
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1 35183254 Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects. 2022 Feb 19 2
2 34188711 Melatonin inhibits gallbladder cancer cell migration and invasion via ERK-mediated induction of epithelial-to-mesenchymal transition. 2021 Aug 3
3 34866924 Melatonin as a Potential Regulator of Oxidative Stress, and Neuroinflammation: Mechanisms and Implications for the Management of Brain Injury-Induced Neurodegeneration. 2021 1
4 31535369 Melatonin attenuates ER stress and mitochondrial damage in septic cardiomyopathy: A new mechanism involving BAP31 upregulation and MAPK-ERK pathway. 2020 Mar 4
5 31906951 Melatonin restores Muc2 depletion induced by V. vulnificus VvpM via melatonin receptor 2 coupling with Gαq. 2020 Jan 6 2
6 31986953 Melatonin receptor protects cardiomyocyte against oxidative stress-induced apoptosis through the MAPK-ERK signaling pathway. 2020 Apr 9
7 32052470 Melatonin enhances thrombopoiesis through ERK1/2 and Akt activation orchestrated by dual adaptor for phosphotyrosine and 3-phosphoinositides. 2020 Apr 1
8 32080899 Melatonin MT1 and MT2 receptor ERK signaling is differentially dependent on Gi/o and Gq/11 proteins. 2020 May 1
9 32088216 Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway. 2020 May 1 2
10 32179814 Usefulness of melatonin as complementary to chemotherapeutic agents at different stages of the angiogenic process. 2020 Mar 16 2
11 32392192 [Melatonin Induces Apoptotic Cell Death in 3T3-L1 Preadipocytes]. 2020 Mar-Apr 2
12 32934681 Melatonin promotes Schwann cell dedifferentiation and proliferation through the Ras/Raf/ERK and MAPK pathways, and glial cell-derived neurotrophic factor expression. 2020 Nov 2
13 30421542 Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β-catenin, and Twist pathways. 2019 Feb 3
14 30444523 Melatonin promotes self-renewal and nestin expression in neural stem cells from the retina. 2019 Jun 1
15 30593827 Potential effects and molecular mechanisms of melatonin on the dopaminergic neuronal differentiation of human amniotic fluid mesenchymal stem cells. 2019 Mar 2
16 30648758 Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: Implications for the treatment of rheumatoid arthritis. 2019 Apr 2
17 31354524 Melatonin Enhances the Usefulness of Ionizing Radiation: Involving the Regulation of Different Steps of the Angiogenic Process. 2019 2
18 31885798 Melatonin Protects Intervertebral Disc from Degeneration by Improving Cell Survival and Function via Activation of the ERK1/2 Signaling Pathway. 2019 1
19 28669047 Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca2+]c/VDAC-[Ca2+]m axis by activation of MAPK/ERK signaling pathway. 2018 Jan 2
20 29320872 Correction to: Bai et al., Melatonin promotes self-renewal of nestin-positive pancreatic stem cells through activation of the MT2/ERK/SMAD/nestin axis. 2018 1
21 29330934 Melatonin inhibits the proliferation of breast cancer cells induced by bisphenol A via targeting estrogen receptor-related pathways. 2018 Mar 1
22 29338098 Increase in motility and invasiveness of MCF7 cancer cells induced by nicotine is abolished by melatonin through inhibition of ERK phosphorylation. 2018 May 8
23 29766567 Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway. 2018 Oct 1
24 30388852 Melatonin Promotes Ubiquitination of Phosphorylated Pro-Apoptotic Protein Bcl-2-Interacting Mediator of Cell Death-Extra Long (BimEL) in Porcine Granulosa Cells. 2018 Nov 1 1
25 28500782 Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence. 2017 Oct 2
26 26639427 Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine. 2016 Jan 26 2
27 26672764 Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells. 2016 Jan 19 3
28 26797706 Melatonin attenuated adipogenesis through reduction of the CCAAT/enhancer binding protein beta by regulating the glycogen synthase 3 beta in human mesenchymal stem cells. 2016 Jun 2
29 25281200 Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. 2015 Feb 5 3
30 25388990 Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling. 2015 Jan 6
31 25431168 Melatonin promotes hepatic differentiation of human dental pulp stem cells: clinical implications for the prevention of liver fibrosis. 2015 Jan 7
32 26645893 Melatonin Induces Cell Apoptosis in AGS Cells Through the Activation of JNK and P38 MAPK and the Suppression of Nuclear Factor-Kappa B: a Novel Therapeutic Implication for Gastric Cancer. 2015 3
33 24720799 Melatonin inhibits MUC5AC production via suppression of MAPK signaling in human airway epithelial cells. 2014 May 1
34 24724723 Melatonin receptor type 1 signals to extracellular signal-regulated kinase 1 and 2 via Gi and Gs dually coupled pathways in HEK-293 cells. 2014 May 6 1
35 24942200 Melatonin promotes the acquisition of neural identity through extracellular-signal-regulated kinases 1/2 activation. 2014 Sep 1
36 25123138 Melatonin suppresses hypoxia-induced migration of HUVECs via inhibition of ERK/Rac1 activation. 2014 Aug 13 3
37 25562159 Melatonin protects the esophageal epithelial barrier by suppressing the transcription, expression and activity of myosin light chain kinase through ERK1/2 signal transduction. 2014 1
38 23397952 The inhibition of TNF-α-induced leucocyte apoptosis by melatonin involves membrane receptor MT1/MT2 interaction. 2013 May 1
39 21988060 Prevention of ERK activation involves melatonin-induced G(1) and G(2) /M phase arrest in the human osteoblastic cell line hFOB 1.19. 2012 Aug 6
40 22050627 Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells. 2012 Mar 4
41 22348531 Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling. 2012 Sep 4
42 22506987 Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin. 2012 Oct 2
43 22507555 Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway. 2012 Oct 2
44 23243457 Inhibition of Connexin 26/43 and Extracellular-Regulated Kinase Protein Plays a Critical Role in Melatonin Facilitated Gap Junctional Intercellular Communication in Hydrogen Peroxide-Treated HaCaT Keratinocyte Cells. 2012 2
45 21497337 Melatonin protects human spermatozoa from apoptosis via melatonin receptor- and extracellular signal-regulated kinase-mediated pathways. 2011 Jun 4
46 21718361 Melatonin modulation of intracellular signaling pathways in hepatocarcinoma HepG2 cell line: role of the MT1 receptor. 2011 Nov 3
47 20050989 Beneficial effects of melatonin on nicotine-induced vasculopathy. 2010 Mar 1
48 21167057 Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway. 2010 5
49 21311676 Melatonin Induces Apoptotic Cell Death via p53 in LNCaP Cells. 2010 Dec 3
50 18930812 ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells. 2009 Feb 1 6