2'-deoxyadenosine triphosphate

apoptotic peptidase activating factor 1 ; Homo sapiens







40 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 33132160 Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9. 2021 Jan 1
2 26265044 MicroRNA-17-mediated down-regulation of apoptotic protease activating factor 1 attenuates apoptosome formation and subsequent apoptosis of cardiomyocytes. 2015 Sep 18 4
3 26543158 Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1. 2015 Nov 15 1
4 24626292 Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung. 2014 May 2
5 24987139 Preparation of cytosolic extracts and activation of caspases by cytochrome c. 2014 Jul 1 2
6 21297999 Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation. 2011 Jan 27 1
7 19383546 Bacterially expressed recombinant WD40 domain of human Apaf-1. 2009 Sep 1
8 19801675 A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome. 2009 Nov 20 1
9 18439902 PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. 2008 Apr 25 1
10 19333786 Mathematical modeling of the formation of apoptosome in intrinsic pathway of apoptosis. 2008 Jun 2
11 17379327 Polycomb group protein RING1B is a direct substrate of Caspases-3 and -9. 2007 Jun 1
12 15794635 A nucleotide binding site in caspase-9 regulates apoptosome activation. 2005 Apr 5 4
13 15829969 Structure of the apoptotic protease-activating factor 1 bound to ADP. 2005 Apr 14 2
14 16271896 A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. 2005 Nov 1
15 12506111 Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP. 2003 Mar 7 2
16 11779177 Subcellular localization, oligomerization, and ATP-binding of Caenorhabditis elegans CED-4. 2002 Jan 11 1
17 11230124 Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. 2001 Mar 1 1
18 11264002 Apaf-1XL is an inactive isoform compared with Apaf-1L. 2001 Mar 23 1
19 11415444 Elevated extracellular [K+] inhibits death-receptor- and chemical-mediated apoptosis prior to caspase activation and cytochrome c release. 2001 Jul 1 1
20 11516099 Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex. 2001 Sep 1
21 11550094 Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex. 2001 Apr 3
22 10617581 Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. 2000 Jan 7 2
23 10687948 Caspase-9. 2000 Feb 1
24 10692394 Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. 2000 Mar 3 1
25 10722681 Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9. 2000 Mar 24 2
26 10862031 Genetic analysis of the APAF1 gene in male germ cell tumors. 2000 Jul 1
27 10934467 Negative regulation of the Apaf-1 apoptosome by Hsp70. 2000 Aug 1
28 10940292 Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. 2000 Oct 6 6
29 11035811 Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength. 2000 Oct 24 3
30 11071652 Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. 2000 Nov 15 1
31 10021389 Bcl-2 regulates amplification of caspase activation by cytochrome c. 1999 Feb 11 1
32 10206961 An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. 1999 Apr 23 3
33 10364241 Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. 1999 Jun 18 2
34 10393175 Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. 1999 Jul 1 5
35 10409627 Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region. 1999 Jul 23 1
36 10611963 Biochemical pathways of caspase activation during apoptosis. 1999 1
37 10619022 HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis. 1999 Nov 1
38 9598997 Activation of caspases triggered by cytochrome c in vitro. 1998 Apr 10 1
39 9689121 Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. 1998 Aug 4 1
40 9390557 Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. 1997 Nov 14 1