| 1 |
33132160 | Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9. | 2021 Jan |
1 |
| 2 |
26265044 | MicroRNA-17-mediated down-regulation of apoptotic protease activating factor 1 attenuates apoptosome formation and subsequent apoptosis of cardiomyocytes. | 2015 Sep 18 |
4 |
| 3 |
26543158 | Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1. | 2015 Nov 15 |
1 |
| 4 |
24626292 | Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung. | 2014 May |
2 |
| 5 |
24987139 | Preparation of cytosolic extracts and activation of caspases by cytochrome c. | 2014 Jul 1 |
2 |
| 6 |
21297999 | Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation. | 2011 Jan 27 |
1 |
| 7 |
19383546 | Bacterially expressed recombinant WD40 domain of human Apaf-1. | 2009 Sep |
1 |
| 8 |
19801675 | A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome. | 2009 Nov 20 |
1 |
| 9 |
18439902 | PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. | 2008 Apr 25 |
1 |
| 10 |
19333786 | Mathematical modeling of the formation of apoptosome in intrinsic pathway of apoptosis. | 2008 Jun |
2 |
| 11 |
17379327 | Polycomb group protein RING1B is a direct substrate of Caspases-3 and -9. | 2007 Jun |
1 |
| 12 |
15794635 | A nucleotide binding site in caspase-9 regulates apoptosome activation. | 2005 Apr 5 |
4 |
| 13 |
15829969 | Structure of the apoptotic protease-activating factor 1 bound to ADP. | 2005 Apr 14 |
2 |
| 14 |
16271896 | A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. | 2005 Nov |
1 |
| 15 |
12506111 | Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP. | 2003 Mar 7 |
2 |
| 16 |
11779177 | Subcellular localization, oligomerization, and ATP-binding of Caenorhabditis elegans CED-4. | 2002 Jan 11 |
1 |
| 17 |
11230124 | Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. | 2001 Mar 1 |
1 |
| 18 |
11264002 | Apaf-1XL is an inactive isoform compared with Apaf-1L. | 2001 Mar 23 |
1 |
| 19 |
11415444 | Elevated extracellular [K+] inhibits death-receptor- and chemical-mediated apoptosis prior to caspase activation and cytochrome c release. | 2001 Jul 1 |
1 |
| 20 |
11516099 | Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex. | 2001 Sep |
1 |
| 21 |
11550094 | Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex. | 2001 Apr |
3 |
| 22 |
10617581 | Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. | 2000 Jan 7 |
2 |
| 23 |
10687948 | Caspase-9. | 2000 Feb |
1 |
| 24 |
10692394 | Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. | 2000 Mar 3 |
1 |
| 25 |
10722681 | Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9. | 2000 Mar 24 |
2 |
| 26 |
10862031 | Genetic analysis of the APAF1 gene in male germ cell tumors. | 2000 Jul |
1 |
| 27 |
10934467 | Negative regulation of the Apaf-1 apoptosome by Hsp70. | 2000 Aug |
1 |
| 28 |
10940292 | Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. | 2000 Oct 6 |
6 |
| 29 |
11035811 | Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength. | 2000 Oct 24 |
3 |
| 30 |
11071652 | Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. | 2000 Nov 15 |
1 |
| 31 |
10021389 | Bcl-2 regulates amplification of caspase activation by cytochrome c. | 1999 Feb 11 |
1 |
| 32 |
10206961 | An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. | 1999 Apr 23 |
3 |
| 33 |
10364241 | Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. | 1999 Jun 18 |
2 |
| 34 |
10393175 | Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. | 1999 Jul 1 |
5 |
| 35 |
10409627 | Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region. | 1999 Jul 23 |
1 |
| 36 |
10611963 | Biochemical pathways of caspase activation during apoptosis. | 1999 |
1 |
| 37 |
10619022 | HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis. | 1999 Nov |
1 |
| 38 |
9598997 | Activation of caspases triggered by cytochrome c in vitro. | 1998 Apr 10 |
1 |
| 39 |
9689121 | Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. | 1998 Aug 4 |
1 |
| 40 |
9390557 | Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. | 1997 Nov 14 |
1 |