40 Article(s)Download |
PMID | Title | Pub. Year | #Total Relationships |
1 | 33132160 | Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9. | 2021 Jan | 1 |
2 | 26265044 | MicroRNA-17-mediated down-regulation of apoptotic protease activating factor 1 attenuates apoptosome formation and subsequent apoptosis of cardiomyocytes. | 2015 Sep 18 | 4 |
3 | 26543158 | Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1. | 2015 Nov 15 | 1 |
4 | 24626292 | Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung. | 2014 May | 2 |
5 | 24987139 | Preparation of cytosolic extracts and activation of caspases by cytochrome c. | 2014 Jul 1 | 2 |
6 | 21297999 | Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation. | 2011 Jan 27 | 1 |
7 | 19383546 | Bacterially expressed recombinant WD40 domain of human Apaf-1. | 2009 Sep | 1 |
8 | 19801675 | A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome. | 2009 Nov 20 | 1 |
9 | 18439902 | PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. | 2008 Apr 25 | 1 |
10 | 19333786 | Mathematical modeling of the formation of apoptosome in intrinsic pathway of apoptosis. | 2008 Jun | 2 |
11 | 17379327 | Polycomb group protein RING1B is a direct substrate of Caspases-3 and -9. | 2007 Jun | 1 |
12 | 15794635 | A nucleotide binding site in caspase-9 regulates apoptosome activation. | 2005 Apr 5 | 4 |
13 | 15829969 | Structure of the apoptotic protease-activating factor 1 bound to ADP. | 2005 Apr 14 | 2 |
14 | 16271896 | A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. | 2005 Nov | 1 |
15 | 12506111 | Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP. | 2003 Mar 7 | 2 |
16 | 11779177 | Subcellular localization, oligomerization, and ATP-binding of Caenorhabditis elegans CED-4. | 2002 Jan 11 | 1 |
17 | 11230124 | Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. | 2001 Mar 1 | 1 |
18 | 11264002 | Apaf-1XL is an inactive isoform compared with Apaf-1L. | 2001 Mar 23 | 1 |
19 | 11415444 | Elevated extracellular [K+] inhibits death-receptor- and chemical-mediated apoptosis prior to caspase activation and cytochrome c release. | 2001 Jul 1 | 1 |
20 | 11516099 | Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex. | 2001 Sep | 1 |
21 | 11550094 | Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex. | 2001 Apr | 3 |
22 | 10617581 | Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. | 2000 Jan 7 | 2 |
23 | 10687948 | Caspase-9. | 2000 Feb | 1 |
24 | 10692394 | Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. | 2000 Mar 3 | 1 |
25 | 10722681 | Expression and functional analysis of Apaf-1 isoforms. Extra Wd-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9. | 2000 Mar 24 | 2 |
26 | 10862031 | Genetic analysis of the APAF1 gene in male germ cell tumors. | 2000 Jul | 1 |
27 | 10934467 | Negative regulation of the Apaf-1 apoptosome by Hsp70. | 2000 Aug | 1 |
28 | 10940292 | Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. | 2000 Oct 6 | 6 |
29 | 11035811 | Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength. | 2000 Oct 24 | 3 |
30 | 11071652 | Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. | 2000 Nov 15 | 1 |
31 | 10021389 | Bcl-2 regulates amplification of caspase activation by cytochrome c. | 1999 Feb 11 | 1 |
32 | 10206961 | An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. | 1999 Apr 23 | 3 |
33 | 10364241 | Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation. | 1999 Jun 18 | 2 |
34 | 10393175 | Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. | 1999 Jul 1 | 5 |
35 | 10409627 | Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region. | 1999 Jul 23 | 1 |
36 | 10611963 | Biochemical pathways of caspase activation during apoptosis. | 1999 | 1 |
37 | 10619022 | HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis. | 1999 Nov | 1 |
38 | 9598997 | Activation of caspases triggered by cytochrome c in vitro. | 1998 Apr 10 | 1 |
39 | 9689121 | Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. | 1998 Aug 4 | 1 |
40 | 9390557 | Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. | 1997 Nov 14 | 1 |