| 1 |
30724552 | Crowders Steal Dihydrofolate Reductase Ligands through Quinary Interactions. | 2019 Mar 5 |
3 |
| 2 |
30979096 | Studies on the Interaction between Poly-Phosphane Gold(I) Complexes and Dihydrofolate Reductase: An Interplay with Nicotinamide Adenine Dinucleotide Cofactor. | 2019 Apr 11 |
2 |
| 3 |
30040418 | Effect of Asp122 Mutation on the Hydride Transfer in E. coli DHFR Demonstrates the Goldilocks of Enzyme Flexibility. | 2018 Aug 23 |
3 |
| 4 |
30564747 | The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. | 2018 |
2 |
| 5 |
28422217 | Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance. | 2017 May 10 |
1 |
| 6 |
24517487 | Investigation of osmolyte effects on FolM: comparison with other dihydrofolate reductases. | 2014 Mar 4 |
4 |
| 7 |
25453083 | Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography. | 2014 Dec 23 |
3 |
| 8 |
23420416 | Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase. | 2013 |
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| 9 |
18724364 | A domino effect in antifolate drug action in Escherichia coli. | 2008 Oct |
1 |
| 10 |
17916364 | Allosteric communication in dihydrofolate reductase: signaling network and pathways for closed to occluded transition and back. | 2007 Nov 16 |
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| 11 |
16241906 | Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase. | 2006 Feb 15 |
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| 12 |
15726569 | Computational methods for the study of enzymic reaction mechanisms III: a perturbation plus QM/MM approach for calculating relative free energies of protonation. | 2005 Apr 30 |
2 |
| 13 |
15213241 | Mass spectrometry on hydrogen/deuterium exchange of dihydrofolate reductase: effects of ligand binding. | 2004 Jun |
1 |
| 14 |
15609999 | Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. | 2004 Dec 28 |
1 |
| 15 |
12756296 | Correlated motion and the effect of distal mutations in dihydrofolate reductase. | 2003 Jun 10 |
2 |
| 16 |
12765545 | Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima. | 2003 Sep 1 |
2 |
| 17 |
12852950 | High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate. | 2003 Aug 4 |
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| 18 |
12862454 | How dihydrofolate reductase facilitates protonation of dihydrofolate. | 2003 Jul 23 |
2 |
| 19 |
12021443 | Role of water in the catalytic cycle of E. coli dihydrofolate reductase. | 2002 Jun |
2 |
| 20 |
11472112 | Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase. | 2001 Apr 18 |
6 |
| 21 |
8003467 | Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications. | 1994 Jun 14 |
4 |
| 22 |
8461309 | How do mutations at phenylalanine-153 and isoleucine-155 partially suppress the effects of the aspartate-27-->serine mutation in Escherichia coli dihydrofolate reductase? | 1993 Apr 6 |
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| 23 |
1961697 | The electrostatic potential of Escherichia coli dihydrofolate reductase. | 1991 |
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| 24 |
2502633 | 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 11. Quinolylmethyl analogues with basic substituents conveying specificity. | 1989 Aug |
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| 25 |
3052577 | Dihydrofolate reductase from Escherichia coli: the kinetic mechanism with NADPH and reduced acetylpyridine adenine dinucleotide phosphate as substrates. | 1988 Jul 26 |
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| 26 |
3275776 | Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. | 1988 Jan |
1 |
| 27 |
7011378 | Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase. | 1981 Feb 17 |
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