| 1 |
35096468 | Single-Molecule Sampling of Dihydrofolate Reductase Shows Kinetic Pauses and an Endosteric Effect Linked to Catalysis. | 2022 Jan 21 |
1 |
| 2 |
34428034 | Role of Active Site Loop Dynamics in Mediating Ligand Release from E. coli Dihydrofolate Reductase. | 2021 Sep 7 |
2 |
| 3 |
34660967 | Effects of Distal Mutations on Ligand-Binding Affinity in E. coli Dihydrofolate Reductase. | 2021 Oct 12 |
1 |
| 4 |
32328689 | Screening of protein-ligand interactions under crude conditions by native mass spectrometry. | 2020 Jul |
3 |
| 5 |
30724552 | Crowders Steal Dihydrofolate Reductase Ligands through Quinary Interactions. | 2019 Mar 5 |
2 |
| 6 |
30979096 | Studies on the Interaction between Poly-Phosphane Gold(I) Complexes and Dihydrofolate Reductase: An Interplay with Nicotinamide Adenine Dinucleotide Cofactor. | 2019 Apr 11 |
4 |
| 7 |
31058257 | NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. | 2019 Mar |
3 |
| 8 |
30040418 | Effect of Asp122 Mutation on the Hydride Transfer in E. coli DHFR Demonstrates the Goldilocks of Enzyme Flexibility. | 2018 Aug 23 |
2 |
| 9 |
30564747 | The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. | 2018 |
2 |
| 10 |
25367157 | Ligand binding to a high-energy partially unfolded protein. | 2015 Jan |
7 |
| 11 |
26407224 | Vacuum-Ultraviolet Circular Dichroism Spectra of Escherichia coli Dihydrofolate Reductase and Its Mutants: Contributions of Phenylalanine and Tyrosine Side Chains and Exciton Coupling of Two Tryptophan Side Chains. | 2015 Oct 15 |
2 |
| 12 |
25453083 | Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography. | 2014 Dec 23 |
3 |
| 13 |
21359214 | Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase. | 2011 Feb 16 |
4 |
| 14 |
20073522 | Nuclear magnetic resonance study of the role of M42 in the solution dynamics of Escherichia coli dihydrofolate reductase. | 2010 Mar 2 |
2 |
| 15 |
21084197 | Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase. | 2010 Dec 15 |
3 |
| 16 |
17877338 | Incorporating dynamics in E. coli dihydrofolate reductase enhances structure-based drug discovery. | 2007 Nov-Dec |
1 |
| 17 |
16241906 | Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase. | 2006 Feb 15 |
2 |
| 18 |
17125251 | A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region. | 2006 Nov 30 |
1 |
| 19 |
15726569 | Computational methods for the study of enzymic reaction mechanisms III: a perturbation plus QM/MM approach for calculating relative free energies of protonation. | 2005 Apr 30 |
4 |
| 20 |
14717591 | Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase. | 2004 Jan 20 |
1 |
| 21 |
15609999 | Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle. | 2004 Dec 28 |
1 |
| 22 |
12765545 | Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima. | 2003 Sep 1 |
2 |
| 23 |
12862454 | How dihydrofolate reductase facilitates protonation of dihydrofolate. | 2003 Jul 23 |
1 |
| 24 |
12021443 | Role of water in the catalytic cycle of E. coli dihydrofolate reductase. | 2002 Jun |
4 |
| 25 |
10063803 | Light activates reduction of methotrexate by NADPH in the ternary complex with Escherichia coli dihydrofolate reductase. | 1999 Jan |
1 |
| 26 |
9572848 | Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase. | 1998 May 5 |
2 |
| 27 |
9398309 | Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant. | 1997 Dec 16 |
2 |
| 28 |
8003467 | Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications. | 1994 Jun 14 |
4 |
| 29 |
8195830 | Basis of selectivity of antibacterial diaminopyrimidines. | 1993 Dec |
1 |
| 30 |
8344289 | A study of the binding of NADP coenzymes to dihydrofolate reductase by raman difference spectroscopy. | 1993 Jul 1 |
2 |
| 31 |
8428582 | Translocation can drive the unfolding of a preprotein domain. | 1993 Jan |
1 |
| 32 |
1747376 | Analysis of hydride transfer and cofactor fluorescence decay in mutants of dihydrofolate reductase: possible evidence for participation of enzyme molecular motions in catalysis. | 1991 Dec 10 |
3 |
| 33 |
1758881 | Changes in the electron density of the cofactor NADPH on binding to E. coli dihydrofolate reductase. | 1991 |
3 |
| 34 |
1834173 | The function of amino acid residues contacting the nicotinamide ring of NADPH in dihydrofolate reductase from Escherichia coli. | 1991 Nov 19 |
2 |
| 35 |
1961697 | The electrostatic potential of Escherichia coli dihydrofolate reductase. | 1991 |
2 |
| 36 |
2037072 | The conformations of trimethoprim/E. coli dihydrofolate reductase complexes. A 15N and 31P NMR study. | 1991 May 20 |
6 |
| 37 |
2108144 | Role of aspartate 27 of dihydrofolate reductase from Escherichia coli in interconversion of active and inactive enzyme conformers and binding of NADPH. | 1990 Apr 5 |
3 |
| 38 |
2185835 | Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state. | 1990 Apr 3 |
3 |
| 39 |
2271540 | Dihydrofolate reductase from Escherichia coli: probing the role of aspartate-27 and phenylalanine-137 in enzyme conformation and the binding of NADPH. | 1990 Sep 18 |
2 |
| 40 |
3052577 | Dihydrofolate reductase from Escherichia coli: the kinetic mechanism with NADPH and reduced acetylpyridine adenine dinucleotide phosphate as substrates. | 1988 Jul 26 |
3 |
| 41 |
3275776 | Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. | 1988 Jan |
1 |
| 42 |
3316211 | Kinetic analysis of the mechanism of Escherichia coli dihydrofolate reductase. | 1987 Nov 25 |
1 |
| 43 |
3082676 | Crystallographic investigation of the cooperative interaction between trimethoprim, reduced cofactor and dihydrofolate reductase. | 1986 Apr 7 |
1 |
| 44 |
3542023 | Nuclear magnetic resonance study of the state of protonation of inhibitors bound to mutant dihydrofolate reductase lacking the active-site carboxyl. | 1986 Nov 4 |
1 |
| 45 |
7011378 | Kinetics of substrate, coenzyme, and inhibitor binding to Escherichia coli dihydrofolate reductase. | 1981 Feb 17 |
2 |
| 46 |
791943 | Interconvertible forms of Escherichia coli dihydrofolate reductase with different affinities for analogs of dihydrofolate. | 1976 Nov 25 |
1 |