Dinoprostone

prostaglandin E receptor 4 (subtype EP4) ; Mus musculus







227 Article(s)
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1 34938150 Changing prostaglandin E2 (PGE2) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE2 receptor EP2 and EP4. 2022 Jan 2
2 35101442 Endosomal TLR3 signaling in stromal osteoblasts induces prostaglandin E2-mediated inflammatory periodontal bone resorption. 2022 Mar 1
3 35131551 Cyclooxygenase-2 contributes to diabetic nephropathy through glomerular EP4 receptor. 2022 Apr 2
4 35260562 PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis. 2022 Mar 9 5
5 35379745 Prostaglandin E2-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation. 2022 Apr 15 3
6 35499079 Cyclooxygenase-2 in adipose tissue macrophages limits adipose tissue dysfunction in obese mice. 2022 May 2 1
7 35588334 Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2/EP4 pathway. 2022 May 19 4
8 32671602 Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. 2021 Oct 2
9 33283987 Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer. 2021 Jan 11 2
10 33558271 Prostaglandin E2 receptor PTGER4-expressing macrophages promote intestinal epithelial barrier regeneration upon inflammation. 2021 Dec 2
11 33634509 Delayed blockage of prostaglandin EP4 receptors can reduce dedifferentiation, epithelial-to-mesenchymal transition and fibrosis following acute kidney injury. 2021 May 1
12 33850845 Macrophage regulator of G-protein signaling 12 contributes to inflammatory pain hypersensitivity. 2021 Mar 1
13 34262017 CD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression. 2021 Jul 14 2
14 34334792 PGE2/EP4 skeleton interoception activity reduces vertebral endplate porosity and spinal pain with low-dose celecoxib. 2021 Aug 2 1
15 34405216 [Overexpression of human EP4 receptor in vascular smooth muscle cells attenuates angiotensin II-induced hypertension in mice]. 2021 Aug 25 1
16 34468315 Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY. 2021 Sep 1 1
17 34471470 TRPV1 Channel Activated by the PGE2/EP4 Pathway Mediates Spinal Hypersensitivity in a Mouse Model of Vertebral Endplate Degeneration. 2021 4
18 34483880 Prostaglandin E2 Dilates Intracerebral Arterioles When Applied to Capillaries: Implications for Small Vessel Diseases. 2021 2
19 34598950 Firefighters for the Wrong Type of Inflammation in Tumors. 2021 Oct 1
20 34719570 [A new therapeutic target for patent ductus arteriosus]. 2021 1
21 35126177 A Vasopressin-Induced Change in Prostaglandin Receptor Subtype Expression Explains the Differential Effect of PGE2 on AQP2 Expression. 2021 3
22 31967309 CP-25 inhibits PGE2-induced angiogenesis by down-regulating EP4/AC/cAMP/PKA-mediated GRK2 translocation. 2020 Feb 14 4
23 32059846 The role of autonomously secreted PGE2 and its autocrine/paracrine effect on bone matrix mineralization at the different stages of differentiating MC3T3-E1 cells. 2020 Apr 16 1
24 32191640 Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones. 2020 Jul 1 2
25 32322056 Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche. 2020 Apr 1
26 32407837 PGE2 deficiency predisposes to anaphylaxis by causing mast cell hyperresponsiveness. 2020 Dec 1
27 32442241 Prostaglandin E2 stimulates the epithelial sodium channel (ENaC) in cultured mouse cortical collecting duct cells in an autocrine manner. 2020 Aug 3 1
28 32484881 Lung fibroblasts produce IL-33 in response to stimulation with retinoblastoma-binding protein 9 via production of prostaglandin E2. 2020 Sep 30 1
29 32531237 TGF-β1-Licensed Murine MSCs Show Superior Therapeutic Efficacy in Modulating Corneal Allograft Immune Rejection In Vivo. 2020 Sep 2 1
30 32618816 The desensitization of the transient receptor potential vanilloid 1 by nonpungent agonists and its resensitization by bradykinin. 2020 Aug 5 1
31 32636414 Prostaglandin E2 breaks down pericyte-endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras. 2020 Jul 7 2
32 32636842 PPARγ as an E3 Ubiquitin-Ligase Impedes Phosphate-Stat6 Stability and Promotes Prostaglandins E2-Mediated Inhibition of IgE Production in Asthma. 2020 2
33 32640908 Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus. 2020 Sep 2
34 33443026 Enhanced Immunotherapeutic Efficacy of Anti-PD-L1 Antibody in Combination with an EP4 Antagonist. 2020 Dec 21 2
35 29935220 T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation. 2019 Feb 1
36 30643142 Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis. 2019 Jan 14 2
37 30764697 Complex Role for E-Prostanoid 4 Receptors in Hypertension. 2019 Feb 19 2
38 31229524 Prostaglandin E2 and an EP4 receptor agonist inhibit LPS-Induced monocyte chemotactic protein 5 production and secretion in mouse cardiac fibroblasts via Akt and NF-κB signaling. 2019 Oct 1
39 31243090 Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2. 2019 Aug 15 1
40 31329160 Antibiotic pretreatment alleviates liver transplant damage in mice and humans. 2019 Jul 22 2
41 31396082 (Pro)renin Receptor-Dependent Induction of Profibrotic Factors Is Mediated by COX-2/EP4/NOX-4/Smad Pathway in Collecting Duct Cells. 2019 2
42 31645712 Epithelial EP4 plays an essential role in maintaining homeostasis in colon. 2019 Oct 23 1
43 31818003 GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice. 2019 Dec 8 2
44 31889132 Oral administration of EP4-selective agonist KAG-308 suppresses mouse knee osteoarthritis development through reduction of chondrocyte hypertrophy and TNF secretion. 2019 Dec 30 1
45 28589946 Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1β-related lung injury. 2018 Mar 2
46 29415894 Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice. 2018 Feb 8 2
47 29593738 Prostaglandin E2 Inhibits Group 2 Innate Lymphoid Cell Activation and Allergic Airway Inflammation Through E-Prostanoid 4-Cyclic Adenosine Monophosphate Signaling. 2018 1
48 29599139 Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury. 2018 May 1
49 30127026 Intestinal host defense outcome is dictated by PGE2 production during efferocytosis of infected cells. 2018 Sep 4 1
50 30332316 Blockade of prostaglandin E2 receptor 4 ameliorates nephrotoxic serum nephritis. 2018 Dec 1 1