olaparib

X-ray repair cross complementing 1 ; Homo sapiens







5 Article(s)
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1 35194903 XRCC1 counteracts poly(ADP ribose)polymerase (PARP) poisons, olaparib and talazoparib, and a clinical alkylating agent, temozolomide, by promoting the removal of trapped PARP1 from broken DNA. 2022 May 2
2 31669203 PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers. 2020 Jan 28 1
3 33425022 XRCC1 deficient triple negative breast cancers are sensitive to ATR, ATM and Wee1 inhibitor either alone or in combination with olaparib. 2020 1
4 27559053 Drug-Driven Synthetic Lethality: Bypassing Tumor Cell Genetics with a Combination of AsiDNA and PARP Inhibitors. 2017 Feb 15 1
5 24770870 Base excision repair defects invoke hypersensitivity to PARP inhibition. 2014 Aug 1