Phosphatidylinositol 4,5-Diphosphate

potassium voltage-gated channel subfamily Q member 2 ; Homo sapiens







23 Article(s)
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1 34767770 Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel. 2022 Jan 19 1
2 35197868 Spotlight on the Binding Affinity of Ion Channels for Phosphoinositides: From the Study of Sperm Flagellum. 2022 1
3 33408002 Ethanol inhibits Kv7.2/7.3 channel open probability by reducing the PI(4,5)P2 sensitivity of Kv7.2 subunit. 2021 Jun 1
4 34650221 PIP2-dependent coupling of voltage sensor and pore domains in Kv7.2 channel. 2021 Oct 14 8
5 33041849 Two KCNQ2 Encephalopathy Variants in the Calmodulin-Binding Helix A Exhibit Dominant-Negative Effects and Altered PIP2 Interaction. 2020 1
6 30478917 Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy. 2019 Jan 2
7 31141688 Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability. 2019 May 28 1
8 29058190 Migration of PIP2 on KCNQ2 Surface Revealed by Molecular Dynamics Simulations. 2018 3
9 29383681 Kv7.3 Compound Heterozygous Variants in Early Onset Encephalopathy Reveal Additive Contribution of C-Terminal Residues to PIP2-Dependent K+ Channel Gating. 2018 Aug 4
10 30008368 Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy. 2018 Oct 1
11 30373787 Pore- and voltage sensor-targeted KCNQ openers have distinct state-dependent actions. 2018 Dec 3 1
12 28283543 KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk. 2017 Jul 4
13 26958886 The Voltage Activation of Cortical KCNQ Channels Depends on Global PIP2 Levels. 2016 Mar 8 1
14 27905566 Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate. 2016 Dec 1 6
15 26359296 Uncoupling PIP2-calmodulin regulation of Kv7.2 channels by an assembly destabilizing epileptogenic mutation. 2015 Nov 1 3
16 26469389 Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation. 2015 Oct 15 2
17 23630338 Quantitative properties and receptor reserve of the DAG and PKC branch of G(q)-coupled receptor signaling. 2013 May 2
18 24086693 Tamoxifen inhibition of kv7.2/kv7.3 channels. 2013 3
19 24277843 Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating. 2013 Dec 10 4
20 22155935 M channel enhancers and physiological M channel block. 2012 Feb 15 1
21 19726551 Receptor-mediated suppression of potassium currents requires colocalization within lipid rafts. 2009 Dec 2
22 18448631 Phosphatidylinositol 4,5-bisphosphate hydrolysis mediates histamine-induced KCNQ/M current inhibition. 2008 Jul 2
23 17344388 Activation of epidermal growth factor receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation. 2007 Mar 7 2