Folic Acid

folylpolyglutamyl synthetase ; Mus musculus







16 Article(s)
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Pub. Year
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1 24532667 Humanizing mouse folate metabolism: conversion of the dual-promoter mouse folylpolyglutamate synthetase gene to the human single-promoter structure. 2014 May 2
2 16169100 Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells. 2005 Oct 30 1
3 12663051 Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. 2003 Apr 1 1
4 11772020 Mouse folylpoly-gamma-glutamate synthetase isoforms respond differently to feedback inhibition by folylpolyglutamate cofactors. 2002 Jan 8 5
5 10856298 Molecular analysis of murine leukemia cell lines resistant to 5, 10-dideazatetrahydrofolate identifies several amino acids critical to the function of folylpolyglutamate synthetase. 2000 Aug 25 1
6 9054377 Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enzyme. 1997 Mar 14 1
7 8605241 Molecular cloning of murine folylpoly-gamma-glutamate synthetase. 1996 Feb 7 2
8 8863812 Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors. 1996 Oct 11 7
9 8937460 Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts. 1996 Nov 8 3
10 8527866 Screening of colon tumor cells and tissues for folylpolyglutamate synthetase activity. 1995 2
11 1741766 The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583). 1991 Oct 24 2
12 2206778 Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity. 1990 1
13 2586490 Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase. 1989 Nov 7
14 3377808 Evaluation of pteroyl-S-alkylhomocysteine sulfoximines as inhibitors of mammalian folylpolyglutamate synthetase. 1988 May 15 1
15 3385729 Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition. 1988 Jul 2
16 2448651 Structural requirements for the activity of antifolates as substrates for mammalian folylpolyglutamate synthetase. 1987 2