| 1 |
31889185 | Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms. | 2020 Mar 18 |
4 |
| 2 |
30698745 | The ATP-bound conformation of the Mre11-Rad50 complex is essential for Tel1/ATM activation. | 2019 Apr 23 |
4 |
| 3 |
31492634 | Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex. | 2019 Nov 7 |
1 |
| 4 |
29374232 | A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair. | 2018 Jan 26 |
4 |
| 5 |
29851556 | Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1. | 2018 Jun 1 |
1 |
| 6 |
28369545 | Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites. | 2017 May 19 |
3 |
| 7 |
27037288 | ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. | 2016 Apr 1 |
1 |
| 8 |
25828805 | Human RAD50 makes a functional DNA-binding complex. | 2015 Jun |
3 |
| 9 |
25887396 | Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia. | 2015 May 29 |
1 |
| 10 |
24493214 | ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. | 2014 Mar 3 |
9 |
| 11 |
25016281 | The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes. | 2014 Nov 15 |
1 |
| 12 |
25213441 | ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends. | 2014 Dec |
5 |
| 13 |
23525106 | Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. | 2013 May 3 |
4 |
| 14 |
24191051 | Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET. | 2013 Nov 19 |
1 |
| 15 |
22927831 | Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. | 2012 Aug |
1 |
| 16 |
21441914 | ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair. | 2011 Apr |
1 |
| 17 |
21511873 | Crystal structure of the Mre11-Rad50-ATPĪ³S complex: understanding the interplay between Mre11 and Rad50. | 2011 May 15 |
2 |
| 18 |
22039049 | DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons. | 2011 Dec 30 |
1 |
| 19 |
19308707 | RAD50, an SMC family member with multiple roles in DNA break repair: how does ATP affect function? | 2009 |
3 |
| 20 |
17386254 | Learning our ABCs: Rad50 directs MRN repair functions via adenylate kinase activity from the conserved ATP binding cassette. | 2007 Mar 23 |
1 |
| 21 |
14698290 | The rad50 signature motif: essential to ATP binding and biological function. | 2004 Jan 23 |
1 |
| 22 |
12384589 | DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. | 2002 Oct 15 |
1 |
| 23 |
11029422 | Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine. | 2000 Nov |
2 |
| 24 |
10346816 | Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. | 1999 May 15 |
3 |
| 25 |
10415333 | Molecular cloning and characterization of splice variants of human RAD50 gene. | 1999 Jul 22 |
1 |