Sunitinib

ret proto-oncogene ; Homo sapiens







52 Article(s)
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1 35358627 Palbociclib in combination with sunitinib exerts a synergistic anti-cancer effect in patient-derived xenograft models of various human cancers types. 2022 Jun 28 1
2 35500680 Necroptosis modulation by cisplatin and sunitinib in hepatocellular carcinoma cell line. 2022 Jul 15 1
3 32578660 Local delivery of sunitinib and Ce6 via redox-responsive zwitterionic hydrogels effectively prevents osteosarcoma recurrence. 2020 Aug 5 2
4 32814829 Enhanced YB1/EphA2 axis signaling promotes acquired resistance to sunitinib and metastatic potential in renal cell carcinoma. 2020 Sep 2
5 28990511 Sunitinib in the Treatment of Thyroid Cancer. 2019 4
6 31025080 Upregulation of phosphoinositide 3-kinase prevents sunitinib-induced cardiotoxicity in vitro and in vivo. 2019 Jun 2
7 28105557 The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. 2017 Apr 1
8 28693255 Sodium butyrate enhances the growth inhibitory effect of sunitinib in human renal cell carcinoma cells. 2017 Jul 4
9 28736633 Biologics in gastrointestinal and pancreatic neuroendocrine tumors. 2017 Jun 2
10 27149458 Recurrent Olfactory Neuroblastoma Treated With Cetuximab and Sunitinib: A Case Report. 2016 May 1
11 25376776 The interplay of cyclic stretch and vascular endothelial growth factor in regulating the initial steps for angiogenesis. 2015 Jan-Feb 1
12 25637219 AXL as a modulator of sunitinib response in glioblastoma cell lines. 2015 Mar 1 2
13 25971960 Receptor Tyrosine Kinase Expression Predicts Response to Sunitinib in Breast Cancer. 2015 Dec 1
14 26003083 Effect of enhanced expression of connexin 43 on sunitinib-induced cytotoxicity in mesothelioma cells. 2015 May 2
15 26291023 Rapid Response to Sunitinib in a Patient with Lung Adenocarcinoma Harboring KIF5B-RET Fusion Gene. 2015 Sep 1
16 24045439 Distinct pathways regulated by RET and estrogen receptor in luminal breast cancer demonstrate the biological basis for combination therapy. 2014 Apr 4
17 24276455 Synergistic cooperation between sunitinib and cisplatin promotes apoptotic cell death in human medullary thyroid cancer. 2014 Feb 2
18 24424564 Sunitinib administered prior to radiotherapy in patients with non-resectable glioblastoma: results of a phase II study. 2014 Dec 1
19 24703573 Activity of sunitinib in extraskeletal myxoid chondrosarcoma. 2014 Jun 1
20 24744988 Will the Requirement by the US FDA to Simultaneously Co-Develop Companion Diagnostics (CDx) Delay the Approval of Receptor Tyrosine Kinase Inhibitors for RTK-Rearranged (ROS1-, RET-, AXL-, PDGFR-α-, NTRK1-) Non-Small Cell Lung Cancer Globally? 2014 1
21 25085632 Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent®) a VEGFR2/PDGFRβ/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial. 2014 Aug 1 4
22 25309777 Molecular pathogenesis and targeted therapies in well-differentiated thyroid carcinoma. 2014 Sep 1
23 23454556 Study of the cellular mechanism of Sunitinib mediated inactivation of activated hepatic stellate cells and its implications in angiogenesis. 2013 Apr 5 1
24 23544171 In Vitro and In Vivo Analysis of RTK Inhibitor Efficacy and Identification of Its Novel Targets in Glioblastomas. 2013 Apr 1
25 24061866 Differential regulation of sunitinib targets predicts its tumor-type-specific effect on endothelial and/or tumor cell apoptosis. 2013 Dec 1
26 30349606 Current and Future Perspectives in Thyroid Carcinoma Treatment. 2013 Mar 1
27 21455800 Concurrent and sequential administration of sunitinib malate and docetaxel in human non-small cell lung cancer cells and xenografts. 2012 Jun 2
28 22080184 A phase II study of sunitinib in recurrent and/or metastatic adenoid cystic carcinoma (ACC) of the salivary glands: current progress and challenges in evaluating molecularly targeted agents in ACC. 2012 Jun 2
29 22191389 Sunitinib exerts only limited effects on the proliferation and differentiation of anaplastic thyroid cancer cells. 2012 Feb 2
30 22442268 Activation of the RAS/RAF/ERK signaling pathway contributes to resistance to sunitinib in thyroid carcinoma cell lines. 2012 Jun 5
31 22866542 Structural and functional analysis of KIT gene encoding receptor tyrosine kinase and its interaction with sunitinib and HDAC inhibitors: an in silico approach. 2012 Feb 1 1
32 23102636 Strategic combination therapy overcomes tyrosine kinase coactivation in adrenocortical carcinoma. 2012 Dec 1
33 21242589 Sunitinib in advanced alveolar soft part sarcoma: evidence of a direct antitumor effect. 2011 Jul 1
34 21325074 Identification of soluble candidate biomarkers of therapeutic response to sunitinib in medullary thyroid carcinoma in preclinical models. 2011 Apr 1 3
35 21469976 Long-term response and postsurgical complete remissions after treatment with sunitinib malate, an oral multitargeted receptor tyrosine kinase inhibitor, in patients with metastatic renal cell carcinoma. 2011 May 1
36 21725210 Sunitinib inhibits papillary thyroid carcinoma with RET/PTC rearrangement but not BRAF mutation. 2011 Sep 1 6
37 19649772 Phase II study of sunitinib malate in head and neck squamous cell carcinoma. 2010 Oct 1
38 19900123 Targeted therapies in the treatment of GIST: Adverse events and maximising the benefits of sunitinib through proactive therapy management. 2010 1
39 20629553 Sunitinib inhibits MEK/ERK and SAPK/JNK pathways and increases sodium/iodide symporter expression in papillary thyroid cancer. 2010 Sep 10
40 20696054 Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors. 2010 1
41 18534874 Sunitinib malate is active against human urothelial carcinoma and enhances the activity of cisplatin in a preclinical model. 2009 Jul-Aug 1
42 19017755 Use of the tyrosine kinase inhibitor sunitinib in a patient with von Hippel-Lindau disease: targeting angiogenic factors in pheochromocytoma and other von Hippel-Lindau disease-related tumors. 2009 Feb 1
43 19453268 Sunitinib in solid tumors. 2009 Jun 1
44 19468197 Medullary thyroid cancer: molecular biology and novel molecular therapies. 2009 1
45 19894779 Sunitinib: a multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies. 2009 1
46 17505827 A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period. 2008 Mar 1
47 17945482 Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma and various other solid tumors. 2008 Feb 1
48 18418222 Sustained clinical responses to tyrosine kinase inhibitor sunitinib in thyroid carcinoma. 2008 Jun 1
49 18537751 Developments in targeted therapy of advanced gastrointestinal stromal tumors. 2008 Jun 1
50 17327610 Sunitinib: from rational design to clinical efficacy. 2007 Mar 1 1