Guanine Nucleotides

MCF.2 cell line derived transforming sequence ; Homo sapiens







36 Article(s)
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Pub. Year
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1 32322580 Targeting Rac and Cdc42 GEFs in Metastatic Cancer. 2020 1
2 30682817 Emerging Roles of Ephexins in Physiology and Disease. 2019 Jan 24 1
3 29515755 CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans. 2018 Feb 9 1
4 26322553 Catching Functional Modes and Structural Communication in Dbl Family Rho Guanine Nucleotide Exchange Factors. 2015 Sep 28 2
5 25014207 Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1. 2014 1
6 23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins. 2013 Feb 8 1
7 21372162 Activation of Dbl restores migration in polyamine-depleted intestinal epithelial cells via Rho-GTPases. 2011 Jun 1
8 20713598 Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPases. 2010 Aug 23 2
9 19670212 The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA. 2009 Oct 1
10 17178836 Regulation of proto-oncogenic dbl by chaperone-controlled, ubiquitin-mediated degradation. 2007 Mar 1
11 17538024 Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42. 2007 Aug 2
12 15455375 Activation of gef-h1, a guanine nucleotide exchange factor for RhoA, by DNA transfection. 2005 Feb 10 1
13 16201754 A Cdc42 mutant specifically activated by intersectin. 2005 Oct 11 1
14 15073184 Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. 2004 Jun 11 1
15 15274927 Crystal structure of the DH/PH fragment of Dbs without bound GTPase. 2004 Jun 1
16 15544329 Oncogenic Dbl, Cdc42, and p21-activated kinase form a ternary signaling intermediate through the minimum interactive domains. 2004 Nov 23 1
17 13679059 Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene. 2003 Oct 3 1
18 11889037 A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. 2002 Mar 15 1
19 11911885 Signaling to the Rho GTPases: networking with the DH domain. 2002 Feb 20 4
20 12006984 Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. 2002 Jun 1
21 11134331 Oligomerization of DH domain is essential for Dbl-induced transformation. 2001 Jan 2
22 11577097 Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins. 2001 Dec 7 1
23 11738596 Dbl family guanine nucleotide exchange factors. 2001 Dec 1
24 10835422 Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands. 2000 Aug 18 1
25 11130063 Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. 2000 Dec 7 2
26 10523665 Dependence of Dbl and Dbs transformation on MEK and NF-kappaB activation. 1999 Nov 1
27 10559246 Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42. 1999 Nov 19 1
28 9846881 Structure and mutagenesis of the Dbl homology domain. 1998 Dec 1
29 9030518 Residues of the Rho family GTPases Rho and Cdc42 that specify sensitivity to Dbl-like guanine nucleotide exchange factors. 1997 Feb 21 3
30 8702569 The pleckstrin homology domain mediates transformation by oncogenic dbl through specific intracellular targeting. 1996 Aug 9 1
31 8724692 Vav: function and regulation in hematopoietic cell signaling. 1996 May 1
32 8791419 The Dbl family of oncogenes. 1996 Apr 1
33 9258606 Oncogene-initiated aberrant signaling engenders the metastatic phenotype: synergistic transcription factor interactions are targets for cancer therapy. 1996 1
34 7476457 Guanine nucleotide exchange catalyzed by dbl oncogene product. 1995 1
35 7941732 Genetic evidence for a functional interaction between Saccharomyces cerevisiae CDC24 and CDC42. 1994 Apr 1
36 8276860 Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. 1994 Jan 7 1