Benzo(a)pyrene

cytochrome P450, family 1, subfamily b, polypeptide 1 ; Mus musculus







24 Article(s)
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1 35052622 Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary DNA Adducts and Cytochrome P450 (CYP)1B1 by Dietary Antioxidants, Omega-3 Fatty Acids, in Mice. 2022 Jan 5 1
2 33800341 Assessment of 9-OH- and 7,8-diol-benzo[a]pyrene in Blood as Potent Markers of Cognitive Impairment Related to benzo[a]pyrene Exposure: An Animal Model Study. 2021 Mar 8 1
3 34216713 Dietary 5-demethylnobiletin modulates xenobiotic-metabolizing enzymes and ameliorates colon carcinogenesis in benzo[a]pyrene-induced mice. 2021 Sep 1
4 32553695 Cytochrome P4501B1 in bone marrow is co-expressed with key markers of mesenchymal stem cells. BMS2 cell line models PAH disruption of bone marrow niche development functions. 2020 Aug 15 2
5 29931584 Alteration of benzo(a)pyrene biotransformation by resveratrol in ApcMin/+ mouse model of colon carcinogenesis. 2019 Apr 1
6 30165701 Cigarette Smoke Toxins-Induced Mitochondrial Dysfunction and Pancreatitis Involves Aryl Hydrocarbon Receptor Mediated Cyp1 Gene Expression: Protective Effects of Resveratrol. 2018 Dec 1 1
7 28007926 Circadian Regulation of Benzo[a]Pyrene Metabolism and DNA Adduct Formation in Breast Cells and the Mouse Mammary Gland. 2017 Mar 4
8 26215100 Screening a mouse liver gene expression compendium identifies modulators of the aryl hydrocarbon receptor (AhR). 2015 Oct 2 1
9 24497629 Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. 2014 Apr 4 3
10 25233930 Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway. 2014 Nov 4
11 23761301 Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm. 2013 Sep 1
12 19666105 Overexpression of Cu/Zn-superoxide dismutase and/or catalase accelerates benzo(a)pyrene detoxification by upregulation of the aryl hydrocarbon receptor in mouse endothelial cells. 2009 Oct 15 1
13 17997381 Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract. 2008 Feb 15 1
14 18372398 Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse. 2008 Jun 1
15 18794127 Cyp1b1 exerts opposing effects on intestinal tumorigenesis via exogenous and endogenous substrates. 2008 Sep 15 2
16 16307768 Benzo(a)pyrene and 7,12-dimethylbenz(a)anthrecene differentially affect bone marrow cells of the lymphoid and myeloid lineages. 2006 Jun 1 1
17 16377763 Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. 2006 Apr 3
18 17049425 Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice. 2006 Dec 15 1
19 15667830 Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity. 2005 Feb 1 2
20 15919055 Inhibition of osteoclast differentiation by polycyclic aryl hydrocarbons is dependent on cell density and RANKL concentration. 2005 Jul 15 6
21 12628579 Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene. 2003 Feb 15 2
22 12649394 Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates. 2003 Apr 3
23 14613719 Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver. 2003 Nov 15 4
24 11741297 Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. 2001 Dec 21 1