Tretinoin

MYCN proto-oncogene, bHLH transcription factor ; Homo sapiens







58 Article(s)
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1 35490242 The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma. 2022 Apr 30 1
2 31903789 Liposomal delivery of hydrophobic RAMBAs provides good bioavailability and significant enhancement of retinoic acid signalling in neuroblastoma tumour cells. 2020 Jul 1
3 32006898 Decitabine and all-trans retinoic acid synergistically exhibit cytotoxicity against elderly AML patients via miR-34a/MYCN axis. 2020 May 3
4 32064173 Erratum: Combining peptide TNIIIA2 with all-trans retinoic acid accelerates N-Myc protein degradation and neuronal differentiation in MYCN-amplified neuroblastoma cells. 2020 1
5 32087738 The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression. 2020 Feb 22 3
6 32240058 MYCN Silencing by RNAi Induces Neurogenesis and Suppresses Proliferation in Models of Neuroblastoma with Resistance to Retinoic Acid. 2020 Aug 3
7 32927768 Isolation and Characterization of Two Novel Colorectal Cancer Cell Lines, Containing a Subpopulation with Potential Stem-Like Properties: Treatment Options by MYC/NMYC Inhibition. 2020 Sep 10 2
8 30906641 Combining peptide TNIIIA2 with all-trans retinoic acid accelerates N-Myc protein degradation and neuronal differentiation in MYCN-amplified neuroblastoma cells. 2019 8
9 31262872 Acyclic Retinoid Combined With Tenascin-C-derived Peptide Reduces the Malignant Phenotype of Neuroblastoma Cells Through N-Myc Degradation. 2019 Jul 2
10 31427086 TAp63 represses transcription of MYCN/NCYM gene and its high levels of expression are associated with favorable outcome in neuroblastoma. 2019 Oct 15 4
11 29301505 Optimising the chick chorioallantoic membrane xenograft model of neuroblastoma for drug delivery. 2018 Jan 4 1
12 28187790 Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance. 2017 Feb 10 4
13 28927789 Anticancer efficacy of p-dodecylaminophenol against high-risk and refractory neuroblastoma cells in vitro and in vivo. 2017 Oct 15 1
14 27531891 Wnt signalling is a bi-directional vulnerability of cancer cells. 2016 Sep 13 1
15 25880909 Functional interplay between MYCN, NCYM, and OCT4 promotes aggressiveness of human neuroblastomas. 2015 Jul 2
16 23565812 Expressional alterations in functional ultra-conserved non-coding RNAs in response to all-trans retinoic acid--induced differentiation in neuroblastoma cells. 2013 Apr 8 2
17 21908575 Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma. 2011 Nov 1 1
18 19550295 Effect of cytotoxic agents and retinoic acid on Myc-N protein expression in neuroblastoma. 2010 Jan 2
19 19766596 Positive auto-regulation of MYCN in human neuroblastoma. 2009 Dec 4 6
20 17420990 Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma. 2008 Feb 2
21 17554788 Retinoic acid induced downregulation of MYCN is not mediated through changes in Sp1/Sp3. 2008 Apr 1
22 18949372 Vasoactive intestinal peptide decreases MYCN expression and synergizes with retinoic acid in a human MYCN-amplified neuroblastoma cell line. 2008 Nov 2
23 17283129 Differential patterns of microRNA expression in neuroblastoma are correlated with prognosis, differentiation, and apoptosis. 2007 Feb 1 2
24 17938259 Combined IFN-gamma and retinoic acid treatment targets the N-Myc/Max/Mad1 network resulting in repression of N-Myc target genes in MYCN-amplified neuroblastoma cells. 2007 Oct 3
25 15592517 Low expression of Wnt-5a gene is associated with high-risk neuroblastoma. 2005 Feb 10 2
26 16166307 High mobility group A1 is a molecular target for MYCN in human neuroblastoma. 2005 Sep 15 4
27 12438307 E2F proteins regulate MYCN expression in neuroblastomas. 2003 Jan 31 1
28 12615055 Combined RAR alpha- and RXR-specific ligands overcome N-myc-associated retinoid resistance in neuroblastoma cells. 2003 Mar 14 1
29 12700651 Retinoic acid decreases targeting of p27 for degradation via an N-myc-dependent decrease in p27 phosphorylation and an N-myc-independent decrease in Skp2. 2003 Feb 5
30 12193473 All-trans-retinoic acid induces nuclear factor kappaB activation and matrix metalloproteinase-9 expression and enhances basement membrane invasivity of differentiation-resistant human SK-N-BE 9N neuroblastoma Cells. 2002 Aug 2
31 11346880 Retinoic acid-induced expression of autotaxin in N-myc-amplified neuroblastoma cells. 2001 Apr 1
32 11668484 Interferon-gamma cooperates with retinoic acid and phorbol ester to induce differentiation and growth inhibition of human neuroblastoma cells. 2001 Oct 1 2
33 11107126 Retinoic-acid-resistant neuroblastoma cell lines show altered MYC regulation and high sensitivity to fenretinide. 2000 Dec 2
34 9605760 Glial cell line-derived neurotrophic factor/neurturin-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret, GFR alpha-1, and GFR alpha-2. 1998 May 15 1
35 9869047 The role of cellular motility in the invasion of human neuroblastoma cells with or without N-myc amplification and expression. 1998 Dec 2
36 9570357 Interferon-gamma and retinoic acid down-regulate N-myc in neuroblastoma through complementary mechanisms of action. 1997 Dec 23 1
37 8570225 Retinoic acid-induced growth arrest and differentiation of neuroblastoma cells are counteracted by N-myc and enhanced by max overexpressions. 1996 Jan 18 4
38 7656409 Reversal of alcohol's effects on neurite extension and on neuronal GAP43/B50, N-myc, and c-myc protein levels by retinoic acid. 1995 May 26 3
39 8519445 Alcohol inhibits neurite extension and increases N-myc and c-myc proteins. 1995 Sep-Oct 1
40 7923112 Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. 1994 Oct 1 1
41 8108182 Induction of interleukin-8 expression in neuroblastoma cells by retinoic acid: implication of leukocyte chemotaxis and activation. 1993 Dec 1
42 8331499 The effect of N-myc amplification and expression on invasiveness of neuroblastoma cells. 1993 Jun 2
43 8401251 Neuroblastoma: the result of multistep transformation? 1993 Jul 1
44 1397312 Plasma membrane redox activity correlates with N-myc expression in neuroblastoma cells. 1992 Oct 19 1
45 1419902 Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc. 1992 Jun 1
46 1565467 Cell type-specific expression and negative regulation by retinoic acid of the human N-myc promoter in neuroblastoma cells. 1992 Apr 1
47 1657899 Down modulation of N-myc, heat-shock protein 70, and nucleolin during the differentiation of human neuroblastoma cells. 1991 Jul 1
48 2013316 Expression of protein kinase C-alpha (PKC-alpha) and MYCN mRNAs in human neuroblastoma cells and modulation during morphological differentiation induced by retinoic acid. 1991 Mar 25 1
49 2068135 Patterns of regulation of nuclear proto-oncogenes MYCN and MYB in retinoic acid treated neuroblastoma cells. 1991 1
50 1697169 Reduction of N-myc expression by antisense RNA is amplified by interferon: possible involvement of the 2-5A system. 1990 Aug 16 1