7-ethyl-7-hydroxy-10H-1,3-Dioxolo(4,5-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-8,11(7H,12H)-dione

MDM4 regulator of p53 ; Homo sapiens







3 Article(s)
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1 34377229 Kras mutation subtypes distinctly affect colorectal cancer cell sensitivity to FL118, a novel inhibitor of survivin, Mcl-1, XIAP, cIAP2 and MdmX. 2021 2
2 28337384 Topoisomerase I (Top1): a major target of FL118 for its antitumor efficacy or mainly involved in its side effects of hematopoietic toxicity? 2017 1
3 25512388 FL118 induces p53-dependent senescence in colorectal cancer cells by promoting degradation of MdmX. 2014 Dec 15 9