gamma-Aminobutyric Acid

solute carrier family 12, member 5 ; Mus musculus







50 Article(s)
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1 34757085 Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn. 2022 Apr 3
2 35370549 Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons. 2022 3
3 35401174 Three-Day Continuous Oxytocin Infusion Attenuates Thermal and Mechanical Nociception by Rescuing Neuronal Chloride Homeostasis via Upregulation KCC2 Expression and Function. 2022 1
4 35185464 Disruption of KCC2 in Parvalbumin-Positive Interneurons Is Associated With a Decreased Seizure Threshold and a Progressive Loss of Parvalbumin-Positive Interneurons. 2021 2
5 29274996 Cortical control of aggression: GABA signalling in the anterior cingulate cortex. 2020 Jan 1
6 31493242 Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain. 2020 Jan 4
7 32012273 Cation-chloride cotransporters and the polarity of GABA signalling in mouse hippocampal parvalbumin interneurons. 2020 May 3
8 30920433 Localization of chloride co-transporters in striatal neurons. 2019 Apr 10 1
9 30977597 Enhanced Social Dominance and Altered Neuronal Excitability in the Prefrontal Cortex of Male KCC2b Mutant Mice. 2019 May 2
10 31541001 Removal of the Potassium Chloride Co-Transporter from the Somatodendritic Membrane of Axotomized Motoneurons Is Independent of BDNF/TrkB Signaling But Is Controlled by Neuromuscular Innervation. 2019 Sep/Oct 1
11 31615901 Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. 2019 Oct 15 3
12 29382760 Restoring GABAergic inhibition rescues memory deficits in a Huntington's disease mouse model. 2018 Feb 13 1
13 29782876 Chloride cotransporter KCC2 is essential for GABAergic inhibition in the SCN. 2018 Aug 1
14 30224498 Potentiating KCC2 activity is sufficient to limit the onset and severity of seizures. 2018 Oct 2 1
15 28054918 APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. 2017 Jan 5 1
16 28143398 A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells. 2017 Jan 31 1
17 28235805 A kainate receptor subunit promotes the recycling of the neuron-specific K+-Cl- co-transporter KCC2 in hippocampal neurons. 2017 Apr 14 1
18 28337033 Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission. 2017 Mar 23 1
19 28962859 Neonatal maternal separation delays the GABA excitatory-to-inhibitory functional switch by inhibiting KCC2 expression. 2017 Nov 25 1
20 26655825 Hyperpolarization-independent maturation and refinement of GABA/glycinergic connections in the auditory brain stem. 2016 Mar 1
21 27025876 Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. 2016 Mar 29 2
22 27052180 The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2. 2016 Apr 5 1
23 25524838 Chronic stress shifts the GABA reversal potential in the hippocampus and increases seizure susceptibility. 2015 Jan 1
24 25596421 KCC2-mediated regulation of respiration-related rhythmic activity during postnatal development in mouse medulla oblongata. 2015 Mar 19 1
25 26126716 WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. 2015 Jun 30 4
26 26539026 KCC2 expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses. 2015 7
27 23246779 Accumulation of GABAergic neurons, causing a focal ambient GABA gradient, and downregulation of KCC2 are induced during microgyrus formation in a mouse model of polymicrogyria. 2014 Apr 2
28 24412803 Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action. 2014 Apr 2
29 24639001 Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS. 2014 Jun 1 2
30 23216656 Type 2 K+ -Cl- cotransporter is preferentially recruited to climbing fiber synapses during development and the stellate cell-targeting dendritic zone at adulthood in cerebellar Purkinje cells. 2013 Feb 1
31 22537560 Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice. 2012 Jun 1
32 23056253 Lack of the sodium-driven chloride bicarbonate exchanger NCBE impairs visual function in the mouse retina. 2012 1
33 21900570 Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor. 2011 Sep 7 1
34 22065950 Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus. 2011 5
35 20089897 In the adult hippocampus, chronic nerve growth factor deprivation shifts GABAergic signaling from the hyperpolarizing to the depolarizing direction. 2010 Jan 20 1
36 20219572 Developmental localization of potassium chloride co-transporter 2 (KCC2), GABA and vesicular GABA transporter (VGAT) in the postnatal mouse somatosensory cortex. 2010 Jun 4
37 20580693 Depolarizing shift in the GABA-induced current reversal potential by lidocaine hydrochloride. 2010 Jul 23 2
38 19236854 Memantine treatment reduces the expression of the K(+)/Cl(-) cotransporter KCC2 in the hippocampus and cerebral cortex, and attenuates behavioural responses mediated by GABA(A) receptor activation in mice. 2009 Apr 10 1
39 19679663 Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation. 2009 Oct 9 7
40 18096599 NKCC1 cotransporter inactivation underlies embryonic development of chloride-mediated inhibition in mouse spinal motoneuron. 2008 Feb 15 1
41 18789906 Cajal-Retzius cells fail to trigger the developmental expression of the Cl- extruding co-transporter KCC2. 2008 Nov 6 3
42 17045484 Brain injury impairs dentate gyrus inhibitory efficacy. 2007 Jan 1
43 17134779 Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum. 2007 Feb 2
44 17715129 A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2. 2007 Oct 19 1
45 17008020 Developmental localization of potassium chloride co-transporter 2 in granule cells of the early postnatal mouse cerebellum with special reference to the synapse formation. 2006 Dec 1
46 15469961 Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride. 2005 Mar 4
47 15567717 Expression of the sodium-driven chloride bicarbonate exchanger NCBE during prenatal mouse development. 2004 Dec 1
48 12810559 Heterogeneous expression of the potassium-chloride cotransporter KCC2 in gonadotropin-releasing hormone neurons of the adult mouse. 2003 Jul 2
49 12000122 Hyperexcitability and epilepsy associated with disruption of the mouse neuronal-specific K-Cl cotransporter gene. 2002 1
50 11395011 Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition. 2001 May 1