Simvastatin

nuclear factor kappa B subunit 1 ; Homo sapiens







35 Article(s)
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1 35123844 Impact of oxidized LDL/LOX-1 system on ligamentum flavum hypertrophy. 2022 Feb 2 2
2 31924353 Simvastatin down-regulates osteogenic response in cultured human aortic valve interstitial cells. 2021 Apr 2
3 32633363 Simvastatin induces apoptosis of nasopharyngeal carcinoma cells through NF-κB signaling pathway. 2020 Jun 3
4 32706497 Simvastatin abolishes nitric oxide- and reactive oxygen species-induced cyclooxygenase-2 expression by blocking the nuclear factor κB pathway in rabbit articular chondrocytes. 2020 Oct 2
5 31934265 Simvastatin Mitigates Apoptosis and Transforming Growth Factor-Beta Upregulation in Stretch-Induced Endothelial Cells. 2019 1
6 29604489 Attenuation of TNF-induced neutrophil adhesion by simvastatin is associated with the inhibition of Rho-GTPase activity, p50 activity and morphological changes. 2018 May 3
7 29872377 Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models. 2018 1
8 31070532 Effect of simvastatin on the SIRT2/NF-κB pathway in rats with acute pulmonary embolism. 2018 Dec 4
9 28910332 Concurrent treatment with simvastatin and NF-κB inhibitor in human castration-resistant prostate cancer cells exerts synergistic anti-cancer effects via control of the NF-κB/LIN28/let-7 miRNA signaling pathway. 2017 2
10 26574150 Statin pretreatment inhibits the lipopolysaccharide-induced epithelial-mesenchymal transition via the downregulation of toll-like receptor 4 and nuclear factor-κB in human biliary epithelial cells. 2016 Jun 2
11 26911804 Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-κB signalling pathway in human chronic myelogenous leukaemia. 2016 Oct 1
12 25547946 Statins impair survival of primary human mesenchymal progenitor cells via mevalonate depletion, NF-κB signaling, and Bnip3. 2015 Mar 2
13 25738368 Molecular mechanism underlying the anticancer effect of simvastatin on MDA-MB-231 human breast cancer cells. 2015 Jul 2
14 25978361 Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin. 2015 May 1
15 24233024 Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products. 2014 Mar 4
16 24392131 Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of astroglial NF-κB activation. 2014 3
17 25013486 Suppressive effects of simvastatin on the human acute promyelocytic leukemia NB4 cell line through the regulation of the nuclear factor-κB signaling pathway. 2014 Aug 5
18 25316568 Simvastatin induces NFκB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells. 2014 Dec 15 2
19 23762985 [Effect of simvastatin on the oxygen transport function and prooxidant - antioxidant balance in blood]. 2013 1
20 23794945 Angiotensin receptor blockers and statins could alleviate atrial fibrosis via regulating platelet-derived growth factor/Rac1/nuclear factor-kappa B Axis. 2013 3
21 22633472 Identical LDL-cholesterol lowering but non-identical effects on NF-κB activity: High dose simvastatin vs combination therapy with ezetimibe. 2012 Jul 1
22 22694979 Simvastatin decreases free radicals formation in the human abdominal aortic aneurysm wall via NF-κB. 2012 Aug 3
23 20060890 Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth. 2010 May 4
24 19008785 Simvastatin reduces endotoxin-induced nuclear factor kappaB activation and mortality in guinea pigs despite lowering circulating low-density lipoprotein cholesterol. 2009 Aug 1
25 18036510 Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway. 2008 Feb 15 3
26 18698233 Statins inhibit toll-like receptor 4-mediated lipopolysaccharide signaling and cytokine expression. 2008 Sep 1
27 17197385 Molecular programming of endothelin-1 in HIV-infected brain: role of Tat in up-regulation of ET-1 and its inhibition by statins. 2007 Mar 1
28 17317725 Modulation of COX-2 expression by statins in human monocytic cells. 2007 Jun 1
29 17464346 The inhibitory effect of simvastatin on the ADMA-induced inflammatory reaction is mediated by MAPK pathways in endothelial cells. 2007 Feb 1
30 17644777 Atorvastatin decreases lipoprotein lipase and endothelial lipase expression in human THP-1 macrophages. 2007 Oct 1
31 17729120 Simvastatin enhances induction of inducible nitric oxide synthase in 3T3-L1 adipocytes. 2007 Sep 1
32 16515553 Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal. 2006 Apr 5
33 15821443 HMG-CoA reductase inhibitors reduce I kappa B kinase activity induced by oxidative stress in monocytes and vascular smooth muscle cells. 2005 May 1
34 12524225 HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. 2003 Jan 1 2
35 12753293 Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. 2003 Jun 6