Cyclosporine

peptidylprolyl isomerase A ; Homo sapiens







144 Article(s)
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51 23152499 Hepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5A. 2012 Dec 28 2
52 23342381 Subtype specific differences in NS5A domain II reveals involvement of proline at position 310 in cyclosporine susceptibility of hepatitis C virus. 2012 Dec 1
53 21396746 Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro. 2011 May 2
54 21489988 Domain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A. 2011 Jun 10 1
55 21593166 Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner. 2011 Jul 2
56 21728990 Evidences of monomer, dimer and trimer of recombinant human cyclophilin A. 2011 Dec 4
57 21963115 Oligopeptide cyclophilin inhibitors: a reassessment. 2011 Nov 5
58 22046132 The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors. 2011 Oct 2
59 24900335 Ranking high affinity ligands of low solubility by NMR spectroscopy. 2011 Jun 9 4
60 20089655 Hepatitis B virus (HBV) surface antigen interacts with and promotes cyclophilin a secretion: possible link to pathogenesis of HBV infection. 2010 Apr 1
61 20132841 The use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A. 2010 May 6
62 20204291 Cyclosporin A and sanglifehrin A enhance chemotherapeutic effect of cisplatin in C6 glioma cells. 2010 Apr 6
63 20364129 Acetylation regulates cyclophilin A catalysis, immunosuppression and HIV isomerization. 2010 May 4
64 20451281 HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors. 2010 Jul 3
65 20602248 Molecular aspects of cyclophilins mediating therapeutic actions of their ligands. 2010 Oct 2
66 20681522 Cyclophilin A is involved in functional expression of the Na(+)-Ca(2+) exchanger NCX1. 2010 Sep 7 2
67 20945139 Novel combinational treatment of cisplatin with cyclophilin A inhibitors in human heptocellular carcinomas. 2010 Sep 2
68 21994697 Cyclophilin inhibitors as a novel HCV therapy. 2010 Aug 1
69 18704644 Knockdown endogenous CypA with siRNA in U2OS cells results in disruption of F-actin structure and alters tumor phenotype. 2009 Jan 2
70 19211263 Characterization of acid-induced protein conformational changes and noncovalent complexes in solution by using coldspray ionization mass spectrometry. 2009 May 2
71 19380579 The isomerase active site of cyclophilin A is critical for hepatitis C virus replication. 2009 Jun 19 1
72 19451286 Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein. 2009 Aug 2
73 19480458 Isoform-specific inhibition of cyclophilins. 2009 Jul 7 1
74 19656870 Target cell type-dependent modulation of human immunodeficiency virus type 1 capsid disassembly by cyclophilin A. 2009 Nov 3
75 19680534 Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. 2009 Aug 2
76 19691347 Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. 2009 Sep 10 1
77 19865066 Cyclophilin A: potential functions and therapeutic target for human cancer. 2009 Nov 2
78 17919644 Cyclophilin A differentially activates monocytes and endothelial cells: role of purity, activity, and endotoxin contamination in commercial preparations. 2008 Apr 1
79 18367226 TRIM5alpha-independent anti-human immunodeficiency virus type 1 activity mediated by cyclophilin A in Old World monkey cells. 2008 Jun 5 1
80 18385230 Cyclophilin A is an essential cofactor for hepatitis C virus infection and the principal mediator of cyclosporine resistance in vitro. 2008 Jun 8
81 18567920 Cyclophilin A up-regulates MMP-9 expression and adhesion of monocytes/macrophages via CD147 signalling pathway in rheumatoid arthritis. 2008 Sep 1
82 18653356 Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection. 2008 Sep 1
83 18673375 A search for cyclophilin-A gene variants in cyclosporine A-treated renal transplanted patients. 2008 Nov-Dec 5
84 18816083 Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencing. 2008 Nov 2
85 18829531 Prolyl isomerase cyclophilin A regulation of Janus-activated kinase 2 and the progression of human breast cancer. 2008 Oct 1 1
86 17267487 A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA. 2007 Apr 3
87 17609268 Fusion of cyclophilin A to Fv1 enables cyclosporine-sensitive restriction of human and feline immunodeficiency viruses. 2007 Sep 2
88 17728232 Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A. 2007 Nov 1
89 17927958 Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans. 2007 Nov 30 3
90 16307882 Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay. 2006 Apr 1 6
91 16372262 Redox regulation of cyclophilin A by glutathionylation. 2006 Feb 2
92 16471698 Thermodynamics of buried water clusters at a protein-ligand binding interface. 2006 Jan 26 4
93 16571786 Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr. 2006 Apr 5
94 16643975 Cyclophilin A: an auxiliary but not necessary cofactor for TRIM5alpha restriction of HIV-1. 2006 Jul 20 1
95 16737676 A fluorescence polarization-based assay for peptidyl prolyl cis/trans isomerase cyclophilin A. 2006 Sep 1 2
96 15706440 Roles of cyclophilins in cancers and other organ systems. 2005 Mar 1
97 15963461 1.88 A crystal structure of the C domain of hCyP33: a novel domain of peptidyl-prolyl cis-trans isomerase. 2005 Aug 5 2
98 16199531 Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells. 2005 Dec 2 1
99 15130913 Cyclophilin A is a proinflammatory cytokine that activates endothelial cells. 2004 Jul 2
100 15283571 Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate. 2004 Aug 1 9