| 1 |
34856334 | SIRT1-FOXOs activity regulates diabetic complications. | 2022 Jan |
2 |
| 2 |
35358824 | Hit evaluation results in 5-benzyl-1,3,4-thiadiazole-2-carboxamide based SIRT2-selective inhibitor with improved affinity and selectivity. | 2022 Jun |
2 |
| 3 |
35441145 | Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration. | 2022 Apr 6 |
2 |
| 4 |
33360352 | A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation. | 2021 Feb |
1 |
| 5 |
33627431 | The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis. | 2021 Feb |
1 |
| 6 |
34108853 | Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders. | 2021 |
4 |
| 7 |
34429771 | Emerging role of SIRT2 in non-small cell lung cancer. | 2021 Oct |
2 |
| 8 |
34695733 | Continuous Sirtuin/HDAC (histone deacetylase) activity assay using thioamides as PET (Photoinduced Electron Transfer)-based fluorescence quencher. | 2021 Dec |
1 |
| 9 |
34925016 | Inhibition of Sirt2 Alleviates Fibroblasts Activation and Pulmonary Fibrosis via Smad2/3 Pathway. | 2021 |
4 |
| 10 |
31692222 | Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology. | 2020 Apr 17 |
1 |
| 11 |
31932479 | E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation. | 2020 Mar 16 |
2 |
| 12 |
32049001 | NAD+ Repletion Rescues Female Fertility during Reproductive Aging. | 2020 Feb 11 |
2 |
| 13 |
32103017 | NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. | 2020 Feb 26 |
2 |
| 14 |
32493816 | An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases. | 2020 Jul 30 |
2 |
| 15 |
32672888 | HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2)*. | 2020 Dec 1 |
2 |
| 16 |
32711564 | Cortactin deacetylation by HDAC6 and SIRT2 regulates neuronal migration and dendrite morphogenesis during cerebral cortex development. | 2020 Jul 25 |
1 |
| 17 |
32831651 | p33ING1b regulates acetylation of p53 in oral squamous cell carcinoma via SIR2. | 2020 |
2 |
| 18 |
32965071 | SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer. | 2020 Nov |
1 |
| 19 |
33061819 | The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response. | 2020 |
3 |
| 20 |
30616888 | The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss. | 2019 Feb 12 |
2 |
| 21 |
30885568 | New SIRT2 inhibitors: Histidine-based bleomycin spin-off. | 2019 May 1 |
1 |
| 22 |
31433161 | SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration. | 2019 Sep 20 |
2 |
| 23 |
31510043 | Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement. | 2019 Sep 10 |
1 |
| 24 |
31604796 | SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly. | 2019 Nov 1 |
2 |
| 25 |
28168426 | Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson's Disease. | 2018 Feb |
1 |
| 26 |
29298345 | Redox modulation of NQO1. | 2018 |
2 |
| 27 |
29371109 | Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus. | 2018 Mar |
1 |
| 28 |
29679549 | CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells. | 2018 Jun 1 |
1 |
| 29 |
29685963 | New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2. | 2018 Jun 5 |
1 |
| 30 |
29685974 | Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2. | 2018 Jun 5 |
1 |
| 31 |
29957526 | X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. | 2018 Jul 15 |
4 |
| 32 |
30114477 | NQO1 regulates mitotic progression and response to mitotic stress through modulating SIRT2 activity. | 2018 Oct |
1 |
| 33 |
30275764 | AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo. | 2018 |
4 |
| 34 |
30568770 | Facile chemoenzymatic synthesis of a novel stable mimic of NAD. | 2018 Nov 28 |
1 |
| 35 |
28053092 | Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. | 2017 Feb 17 |
1 |
| 36 |
28073696 | SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth. | 2017 Feb 5 |
1 |
| 37 |
28240897 | Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity. | 2017 Mar 23 |
1 |
| 38 |
28286128 | Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure. | 2017 Mar 16 |
2 |
| 39 |
28301150 | Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis. | 2017 Apr 24 |
1 |
| 40 |
28445509 | Functional genetic variants within the SIRT2 gene promoter in acute myocardial infarction. | 2017 |
1 |
| 41 |
28506746 | The NAD+-dependent deacetylase, Bifidobacterium longum Sir2 in response to oxidative stress by deacetylating SigH (σH) and FOXO3a in Bifidobacterium longum and HEK293T cell respectively. | 2017 Jul |
2 |
| 42 |
28808418 | Emerging roles of SIRT1 in fatty liver diseases. | 2017 |
4 |
| 43 |
28973648 | The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes. | 2017 Nov 1 |
1 |
| 44 |
28989670 | Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site. | 2017 Sep 1 |
5 |
| 45 |
29213065 | Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency. | 2017 Dec 6 |
2 |
| 46 |
29239724 | SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. | 2017 Dec 14 |
4 |
| 47 |
26414199 | HDAC4 stabilizes SIRT1 via sumoylation SIRT1 to delay cellular senescence. | 2016 Jan |
2 |
| 48 |
26647771 | SIRT2 mediates multidrug resistance in acute myelogenous leukemia cells via ERK1/2 signaling pathway. | 2016 Feb |
2 |
| 49 |
26794150 | Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-Cell Chronic Lymphocytic Leukemia (CLL). | 2016 |
1 |
| 50 |
26982234 | 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors. | 2016 Apr 14 |
1 |