Levodopa

glutamate receptor, ionotropic, kainate 1 ; Mus musculus







20 Article(s)
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1 30259400 Genetic Knockdown of mGluR5 in Striatal D1R-Containing Neurons Attenuates L-DOPA-Induced Dyskinesia in Aphakia Mice. 2019 Jun 2
2 31422483 Group I metabotropic glutamate receptors in the primate motor thalamus: subsynaptic association with cortical and sub-cortical glutamatergic afferents. 2019 Nov 1
3 29055799 Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson's disease and levodopa-induced dyskinesia. 2018 Jan 4
4 30271338 Effects of mGluR5 Antagonists on Parkinson's Patients With L-Dopa-Induced Dyskinesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 2018 2
5 30439288 L-DOPA-Induced Motor Impairment and Overexpression of Corticostriatal Synaptic Components Are Improved by the mGluR5 Antagonist MPEP in 6-OHDA-Lesioned Rats. 2018 Jan-Dec 1
6 27214664 A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease. 2016 Sep 1
7 24865335 The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque model. 2014 Jul 1
8 24960254 Mavoglurant as a treatment for Parkinson's disease. 2014 Aug 2
9 24029003 Modulating mGluR5 and 5-HT1A/1B receptors to treat l-DOPA-induced dyskinesia: effects of combined treatment and possible mechanisms of action. 2013 Dec 1
10 21161716 Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia. 2011 Dec 1
11 21484883 The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl) pyridine decreases striatal VGlut2 expression in association with an attenuation of L-DOPA-induced dyskinesias. 2011 Oct 1
12 20074579 Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys. 2010 Jun 1
13 20132464 Effect of L-Dopa on metabotropic glutamate receptor 5 in the brain of parkinsonian monkeys. 2010 May 9
14 20452425 A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys. 2010 Sep 1
15 19660528 Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats. 2009 Nov 10 4
16 17353071 mGluR5 metabotropic glutamate receptors and dyskinesias in MPTP monkeys. 2008 Jul 1
17 17933546 Systemic administration of an mGluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesias in a rodent model of Parkinson's disease. 2008 Jan 2
18 18690408 Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats. 2008 Dec 1
19 17359492 Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease. 2007 Apr 2
20 16564428 Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease. 2006 Apr 14 1