Lactic Acid

solute carrier family 16 member 3 ; Homo sapiens







121 Article(s)
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1 34472101 l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters. 2022 Jan 1
2 34619707 Coexpression of MCT1 and MCT4 in ALK-positive Anaplastic Large Cell Lymphoma: Diagnostic and Therapeutic Implications. 2022 Feb 1 1
3 34710950 An ROS-Activatable Nanoassembly Remodulates Tumor Cell Metabolism for Enhanced Ferroptosis Therapy. 2022 Jan 1
4 34822124 Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning. 2022 Feb 1
5 34843897 Lactate Supply from Astrocytes to Neurons and its Role in Ischemic Stroke-induced Neurodegeneration. 2022 Jan 15 1
6 35043976 Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack. 2022 Jan 19 2
7 35050463 Heat shock protein A12A activates migration of hepatocellular carcinoma cells in a monocarboxylate transporter 4-dependent manner. 2022 Jan 1
8 35075123 Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer. 2022 Jan 24 1
9 35102189 Effect of endurance training and PGC-1α overexpression on calculated lactate production volume during exercise based on blood lactate concentration. 2022 Jan 31 1
10 35239073 Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma. 2022 Mar 3 1
11 35509603 Lactate Transporter SLC16A3 (MCT4) as an Onco-Immunological Biomarker Associating Tumor Microenvironment and Immune Responses in Lung Cancer. 2022 1
12 35561786 TGF-β1 induced autophagy in cancer associated fibroblasts during hypoxia contributes EMT and glycolysis via MCT4 upregulation. 2022 Aug 1 1
13 33540599 In Vitro and In Vivo Characterization of MCT1 Inhibitor AZD3965 Confirms Preclinical Safety Compatible with Breast Cancer Treatment. 2021 Feb 2 1
14 33596451 Lactate released from human fibroblasts enhances Ni elution from Ni plate. 2021 Apr 15 2
15 33968927 Evaluation of Monocarboxylate Transporter 4 (MCT4) Expression and Its Prognostic Significance in Circulating Tumor Cells From Patients With Early Stage Non-Small-Cell Lung Cancer. 2021 2
16 34471053 Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells. 2021 1
17 34513685 Integrative Analysis Identified MCT4 as an Independent Prognostic Factor for Bladder Cancer. 2021 3
18 34671407 LINC00035 Transcriptional Regulation of SLC16A3 via CEBPB Affects Glycolysis and Cell Apoptosis in Ovarian Cancer. 2021 1
19 31395464 Monocarboxylate transporters in cancer. 2020 Mar 1
20 31711985 The NF-κB/miR-425-5p/MCT4 axis: A novel insight into diabetes-induced endothelial dysfunction. 2020 Jan 15 3
21 31738978 Role of monocarboxylate transporter 4 in Alzheimer disease. 2020 Jan 1
22 31963392 SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner. 2020 Jan 17 2
23 31964840 Imaging breast cancer using hyperpolarized carbon-13 MRI. 2020 Jan 28 1
24 32002519 MCT4 regulates de novo pyrimidine biosynthesis in GBM in a lactate-independent manner. 2020 Jan-Dec 1
25 32416791 Altered expression of lactate dehydrogenase and monocarboxylate transporter involved in lactate metabolism in broiler wooden breast. 2020 Jan 2
26 32468005 Comparison of neuronal death and expression of TNF‑α and MCT4 in the gerbil hippocampal CA1 region induced by ischemia/reperfusion under hyperthermia to those under normothermia. 2020 Aug 3
27 32633891 Positive feedback in Cav-1-ROS signalling in PSCs mediates metabolic coupling between PSCs and tumour cells. 2020 Aug 2
28 32650130 Targeting lactate production and efflux in prostate cancer. 2020 Nov 1 1
29 32695876 Monocarboxylate Transporter 4 Is a Therapeutic Target in Non-small Cell Lung Cancer with Aerobic Glycolysis Preference. 2020 Sep 25 1
30 32782531 Prognostic and predictive value of monocarboxylate transporter 4 in patients with breast cancer. 2020 Sep 2
31 32808215 Monitoring Lactate Dynamics in Individual Macrophages with a Genetically Encoded Probe. 2020 2
32 33184582 Lactate Exposure Promotes Immunosuppressive Phenotypes in Innate Immune Cells. 2020 Oct 1
33 33614502 Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells. 2020 3
34 30270512 The prognostic significance of the expression of monocarboxylate transporter 4 in patients with right- or left-sided colorectal cancer. 2019 Apr 2
35 30809511 Potential Therapies for Infectious Diseases Based on Targeting Immune Evasion Mechanisms That Pathogens Have in Common With Cancer Cells. 2019 1
36 31217781 MCT4 promotes cell proliferation and invasion of castration-resistant prostate cancer PC-3 cell line. 2019 1
37 31271899 Hypoxia-induced RelA/p65 derepresses SLC16A3 (MCT4) by downregulating ZBTB7A. 2019 Aug 5
38 31297034 Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells. 2019 1
39 31479685 Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma. 2019 Nov 1 6
40 31530214 Changes of Metabolic Phenotype of Cardiac Progenitor Cells During Differentiation: Neutral Effect of Stimulation of AMP-Activated Protein Kinase. 2019 Nov 15 1
41 31719150 Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments. 2019 Dec 27 10
42 28846107 Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells. 2018 Jan 4 3
43 29854024 Evaluation of Monocarboxylate Transporter 4 in Inflammatory Bowel Disease and Its Potential Use as a Diagnostic Marker. 2018 5
44 29905005 Targeting MCT4 to reduce lactic acid secretion and glycolysis for treatment of neuroendocrine prostate cancer. 2018 Jun 14 3
45 30177396 Genetic variations in the monocarboxylate transporter genes (SLC16A1, SLC16A3, and SLC16A11) in the Japanese population. 2018 Oct 1
46 30262589 Selective Inhibition of the Lactate Transporter MCT4 Reduces Growth of Invasive Bladder Cancer. 2018 Dec 3
47 30540938 Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. 2018 Dec 11 3
48 27859555 Pyruvate cellular uptake and enzymatic conversion probed by dissolution DNP-NMR: the impact of overexpressed membrane transporters. 2017 Jun 2
49 28107190 Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. 2017 Apr 11 2
50 28222424 1α,25(OH) 2D3 Sensitive Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Ishikawa Cells. 2017 1