Cyclosporine

ATP-binding cassette, subfamily B (MDR/TAP), member 1B ; Rattus norvegicus







139 Article(s)
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51 17117422 Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY. 2007 Feb 1
52 17207946 Intestinal absorption of novel-dipeptide prodrugs of saquinavir in rats. 2007 May 24 1
53 17365275 P-glycoprotein mediates brain-to-blood efflux transport of buprenorphine across the blood-brain barrier. 2007 Jan 1
54 17609666 Irradiation of rat brain reduces P-glycoprotein expression and function. 2007 Aug 6 1
55 17664251 Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. 2007 Nov 2
56 17845805 Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats. 2007 Oct 1
57 19093450 Membrane transport of andrographolide in artificial membrane and rat small intestine. 2007 Jun 15 1
58 16252067 Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp). 2006 Jul 5
59 16353156 Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation. 2006 May 15 1
60 16415090 Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data. 2006 May 1
61 16457995 Limited interaction between tacrolimus and P-glycoprotein in the rat small intestine. 2006 May 3
62 16476567 Effect of cyclosporin A on the biliary excretion of cholephilic compounds in rats. 2006 Mar 4
63 16545584 Development and characterization of LLC-PK1 cells containing Sprague-Dawley rat Abcb1a (Mdr1a): comparison of rat P-glycoprotein transport to human and mouse. 2006 Jul-Aug 1
64 16793245 Influence of Verapamil and Cyclosporin A on bile acid metabolism and transport in rat liver slices. 2006 Aug 3
65 16805961 Effect of imatinib mesilate on the disposition kinetics of ciclosporin in rats. 2006 Jul 1
66 16857389 Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET. 2006 Sep 5
67 17015956 Radiosynthesis and evaluation of 11C-labeled diaryl-substituted imidazole and indole derivatives for mapping cyclooxygenase-2. 2006 Oct 3
68 15620875 Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier. 2005 Jan 20 2
69 15624117 Influence of P-glycoprotein inhibition on the distribution of the tricyclic antidepressant nortriptyline over the blood-brain barrier. 2005 Mar 2
70 15684491 In vivo effects of cyclosporin A and ketoconazole on the pharmacokinetics of representative substrates for P-glycoprotein and cytochrome P450 (CYP) 3A in rats. 2005 Feb 5
71 15858844 Role of organic anion transporting polypeptide 2 in pharmacokinetics of digoxin and beta-methyldigoxin in rats. 2005 Jun 2
72 15909533 Measurement of unbound ranitidine in blood and bile of anesthetized rats using microdialysis coupled to liquid chromatography and its pharmacokinetic application. 2005 May 6 1
73 15910387 Elevated blood concentrations of calcineurin inhibitors during diarrheal episode in pediatric liver transplant recipients: involvement of the suppression of intestinal cytochrome P450 3A and P-glycoprotein. 2005 Jun 3
74 15951832 New positron emission tomography tracer [(11)C]carvedilol reveals P-glycoprotein modulation kinetics. 2005 Aug 3
75 16085598 Synthesis and evaluation of dopamine D3 receptor antagonist 11C-GR218231 as PET tracer for P-glycoprotein. 2005 Aug 3
76 15039293 Hepatobiliary excretion of berberine. 2004 Apr 1
77 15114410 Effect of cyclosporine A on the tissue distribution and pharmacokinetics of etoposide. 2004 Aug 4
78 15187451 Involvement of P-glycoprotein in blood-brain barrier transport of pentazocine in rats using brain uptake index method. 2004 Jun 1
79 15482640 Decrease in oral bioavailability of ciclosporin by intravenous pulse of methylprednisolone succinate in rats. 2004 Oct 1
80 15638085 Effect of p-glycoprotein inhibitor combinations on drug efflux from rat brain microvessel endothelial cells. 2004 Dec 2
81 12612437 Cyclosporine a augments P-glycoprotein expression in the regenerating rat liver. 2003 Mar 5
82 12626638 Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. 2003 Jun 1
83 12644037 Hydrophilic bile salts have a cytoprotective effect against cyclosporine A-induced cholestasis through enhanced canalicular membrane fluidity and transporter activity. 2003 Jan 2
84 12817897 Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats. 2003 Jun 3
85 12820149 Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and beta-methyldigoxin in rats. 2003 Jul 1
86 14642487 Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET. 2003 Nov 2
87 14743973 Effect of P-glycoprotein inhibitors erythromycin and cyclosporin A on brain pharmacokinetics of nimodipine in rats. 2003 Oct-Dec 1
88 11796340 Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats. 2002 Feb 1
89 11861816 Pharmacokinetic role of P-glycoprotein in oral bioavailability and intestinal secretion of grepafloxacin in vivo. 2002 Mar 1
90 11897974 Role of chiral chromatography in therapeutic drug monitoring and in clinical and forensic toxicology. 2002 Apr 3
91 11918846 Cyclosporin A enhanced protection of nimodipine against brain damage induced by hypoxia-ischemia in mice and rats. 2002 Mar 5
92 12112443 Functional expression and localization of P-glycoprotein at the blood brain barrier. 2002 Jun 1 1
93 12113888 Tissue-specific regulation of expression and activity of P-glycoprotein in adjuvant arthritis rats. 2002 Jul 2
94 12235265 Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate. 2002 Oct 1
95 12405759 Determination of naringin in rat blood, brain, liver, and bile using microdialysis and its interaction with cyclosporin a, a p-glycoprotein modulator. 2002 Nov 6 1
96 12427482 Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. 2002 Dec 6 3
97 12466241 The effects of the cyclosporin A, a P-glycoprotein inhibitor, on the pharmacokinetics of baicalein in the rat: a microdialysis study. 2002 Dec 2
98 12530470 The involvement of P-glycoprotein in berberine absorption. 2002 Oct 3
99 11217075 Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions. 2001 Feb 1
100 11237863 Cyclosporin A reduces canalicular membrane fluidity and regulates transporter function in rats. 2001 Mar 15 1