olaparib

checkpoint kinase 1 ; Homo sapiens







11 Article(s)
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PMID
Title
Pub. Year
#Total Relationships
1 35000525 Repeated treatments of Capan-1 cells with PARP1 and Chk1 inhibitors promote drug resistance, migration and invasion. 2022 Dec 31 1
2 35051747 Recent advances in DDR (DNA damage response) inhibitors for cancer therapy. 2022 Feb 15 1
3 33412559 Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells. 2021 1
4 34131002 Phase 1 Combination Study of the CHK1 Inhibitor Prexasertib and the PARP Inhibitor Olaparib in High-grade Serous Ovarian Cancer and Other Solid Tumors. 2021 Sep 1 1
5 34206543 Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells. 2021 Jun 22 1
6 33352723 PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality-An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness. 2020 Dec 19 3
7 30201826 Repurposing of mTOR Complex Inhibitors Attenuates MCL-1 and Sensitizes to PARP Inhibition. 2019 Jan 1
8 28490518 CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib. 2017 Jul 15 1
9 24413181 Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors. 2014 Mar 1
10 24694947 New insights into PARP inhibitors' effect on cell cycle and homology-directed DNA damage repair. 2014 Jun 1
11 23917378 PARP and CHK inhibitors interact to cause DNA damage and cell death in mammary carcinoma cells. 2013 May 1