Doxorubicin

checkpoint kinase 2 ; Homo sapiens







19 Article(s)
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Pub. Year
#Total Relationships
1 30665195 Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21. 2019 Feb 22 1
2 31759252 APC loss affects DNA damage repair causing doxorubicin resistance in breast cancer cells. 2019 Dec 1
3 29316526 Part II: New candidates of pyrazole-benzimidazole conjugates as checkpoint kinase 2 (Chk2) inhibitors. 2018 Jan 20 1
4 29775409 Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells. 2018 Sep 1 2
5 30405800 Low dose dinaciclib enhances doxorubicin-induced senescence in myeloma RPMI8226 cells by transformation of the p21 and p16 pathways. 2018 Nov 2
6 27403577 The Effect of Caffeine and chk2 Inhibitor on Doxorubicin-Induced Cellular Senescence in MCF-7 Cells. 2016 Sep 3
7 27888802 Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption. 2016 Dec 20 1
8 25478729 Alternation of adriamycin penetration kinetics in MCF-7 cells from 2D to 3D culture based on P-gp expression through the Chk2/p53/NF-κB pathway. 2015 Jan 15 1
9 25683911 Chk1 and Wee1 control genotoxic-stress induced G2-M arrest in melanoma cells. 2015 May 1
10 25535901 Distinct DNA damage determines differential phosphorylation of Chk2. 2014 1
11 20959117 Sodium salicylate is a novel catalytic inhibitor of human DNA topoisomerase II alpha. 2011 Feb 1 1
12 21624350 ALCAPs induce mitochondrial apoptosis and activate DNA damage response by generating ROS and inhibiting topoisomerase I enzyme activity in K562 leukemia cell line. 2011 Jun 17 1
13 19996108 Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control. 2010 Jan 29 1
14 20526748 Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases. 2010 Sep 1
15 19453842 Cellular effects of genotoxic stress and gene silencing of the checkpoint kinases in human oral cells. 2009 Aug 2
16 15707569 The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint. 2005 Mar 10 4
17 16150728 DNA damage regulates Chk2 association with chromatin. 2005 Nov 11 1
18 15489221 Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. 2004 Dec 17 2
19 11741320 Etoposide and adriamycin but not genistein can activate the checkpoint kinase Chk2 independently of ATM/ATR. 2001 Dec 21 3