Phosphatidylinositol 4,5-Diphosphate

potassium voltage-gated channel subfamily Q member 1 ; Homo sapiens







22 Article(s)
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1 34958868 PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K+ channel activity by mutant α1B-adrenergic receptors. 2022 Mar 2
2 31883792 Structural Basis of Human KCNQ1 Modulation and Gating. 2020 Jan 23 1
3 32678288 A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation. 2020 Jul 16 3
4 33310856 Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening. 2020 Dec 5
5 33355140 A unique mechanism of inactivation gating of the Kv channel family member Kv7.1 and its modulation by PIP2 and calmodulin. 2020 Dec 3
6 28096388 Competition of calcified calmodulin N lobe and PIP2 to an LQT mutation site in Kv7.1 channel. 2017 Jan 31 6
7 28575668 Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome. 2017 Jun 1 2
8 28976808 Ca2+-Calmodulin and PIP2 interactions at the proximal C-terminus of Kv7 channels. 2017 Nov 2 4
9 29020060 Phosphatidylinositol-4,5-bisphosphate is required for KCNQ1/KCNE1 channel function but not anterograde trafficking. 2017 4
10 25559286 PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6. 2015 Jan 6 3
11 26469389 Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation. 2015 Oct 15 1
12 26668384 KCNE3 acts by promoting voltage sensor activation in KCNQ1. 2015 Dec 29 1
13 24904429 PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating. 2014 1
14 24947509 Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning. 2014 Aug 15 3
15 25037568 Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂. 2014 Sep 15 4
16 23861489 Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. 2013 Aug 6 2
17 22787448 Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels. 2012 3
18 19139916 Regulation of wild-type and mutant KCNQ1/KCNE1 channels by tyrosine kinase. 2009 Jul 2
19 15677683 PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels. 2005 Apr 1 1
20 15746441 Impaired KCNQ1-KCNE1 and phosphatidylinositol-4,5-bisphosphate interaction underlies the long QT syndrome. 2005 Apr 15 5
21 15579540 Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. 2004 Dec 1 1
22 14532114 Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels. 2003 Oct 15 2