| 1 |
19561084 | Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR. | 2009 Aug 21 |
1 |
| 2 |
19781106 | Early responses of insulin signaling to high-carbohydrate and high-fat overfeeding. | 2009 Sep 28 |
1 |
| 3 |
16354680 | Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. | 2006 Jan |
2 |
| 4 |
16395615 | Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects. | 2006 Feb |
1 |
| 5 |
16574739 | Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation. | 2006 Aug |
2 |
| 6 |
15855334 | Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study. | 2005 May |
1 |
| 7 |
15919784 | Dose-response effect of elevated plasma free fatty acid on insulin signaling. | 2005 Jun |
1 |
| 8 |
14693696 | Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane. | 2004 Jan |
1 |
| 9 |
14769130 | Muscarinic-receptor-mediated inhibition of insulin-like growth factor-1 receptor-stimulated phosphoinositide 3-kinase signalling in 1321N1 astrocytoma cells. | 2004 May 1 |
2 |
| 10 |
15292339 | Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects. | 2004 Aug |
1 |
| 11 |
15316008 | SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. | 2004 Oct 15 |
2 |
| 12 |
12510059 | Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. | 2003 Mar 7 |
2 |
| 13 |
12525499 | Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes. | 2003 Mar 21 |
1 |
| 14 |
11832350 | Defective Akt activation is associated with glucose- but not glucosamine-induced insulin resistance. | 2002 Mar |
2 |
| 15 |
11171554 | Skeletal muscle and insulin sensitivity: pathophysiological alterations. | 2001 Feb 1 |
1 |
| 16 |
11384880 | Multiple signal transduction pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase in normal and tumoral target tissues. | 2001 Jan-Mar |
1 |
| 17 |
11438661 | Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. | 2001 Aug |
1 |
| 18 |
11498541 | Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. | 2001 Oct 12 |
2 |
| 19 |
11526109 | Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting. | 2001 Nov 2 |
1 |
| 20 |
10674396 | Multiple signaling pathways mediate interleukin-4-induced 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase type 1 gene expression in human breast cancer cells. | 2000 Feb |
1 |
| 21 |
10847581 | A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. | 2000 Jun |
1 |
| 22 |
10847585 | Different subcellular localization and phosphoinositides binding of insulin receptor substrate protein pleckstrin homology domains. | 2000 Jun |
1 |
| 23 |
10320056 | Insulin-mediated pseudoacromegaly in a patient with severe insulin resistance: association of defective insulin-stimulated glucose transport with impaired phosphatidylinositol 3-kinase activity in fibroblasts. | 1999 |
1 |
| 24 |
9693122 | PTB domain of insulin receptor substrate-1 binds inositol compounds. | 1998 Aug 15 |
3 |
| 25 |
9753293 | Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. | 1998 Oct |
1 |
| 26 |
8999900 | Prolactin activates tyrosyl phosphorylation of insulin receptor substrate 1 and phosphatidylinositol-3-OH kinase. | 1997 Jan 24 |
1 |
| 27 |
9036989 | Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha. | 1997 Mar 1 |
1 |
| 28 |
8628286 | Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain. | 1996 May |
1 |
| 29 |
8647950 | A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. | 1996 Jun 1 |
3 |
| 30 |
8660383 | Differential regulation of insulin-stimulated tyrosine phosphorylation of IRS-1 and SHC by Wortmannin in intact cells. | 1996 Jun 5 |
3 |
| 31 |
8739921 | Molecular scanning of the insulin receptor substrate-1 (IRS-1) gene in Japanese patients with NIDDM: identification of five novel polymorphisms. | 1996 May |
3 |
| 32 |
7782332 | Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. | 1995 Jun 16 |
1 |
| 33 |
7507665 | Correlation of the insulin receptor substrate-1 with insulin-responsive deoxyglucose transport in 3T3-L1 adipocytes. | 1994 Jan 28 |
1 |
| 34 |
7520748 | Potent activation of phosphatidylinositol 3'-kinase by simple phosphotyrosine peptides derived from insulin receptor substrate 1 containing two YMXM motifs for binding SH2 domains. | 1994 Aug 16 |
2 |
| 35 |
7983060 | Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells. | 1994 Dec 9 |
1 |
| 36 |
8388384 | Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2. | 1993 May 25 |
1 |
| 37 |
1332046 | IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. | 1992 Nov 1 |
1 |