| 1 |
33422633 | Plasma from obese children increases monocyte-endothelial adhesion and affects intracellular insulin signaling in cultured endothelial cells: Potential role of mTORC1-S6K1. | 2021 Apr 1 |
2 |
| 2 |
31005665 | Nicotine inhibits rapamycin-induced pain through activating mTORC1/S6K/IRS-1-related feedback inhibition loop. | 2019 Jul |
1 |
| 3 |
29483302 | Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival. | 2018 May 15 |
2 |
| 4 |
28831455 | Inhibition of p70S6K does not mimic the enhancement of Akt phosphorylation by rapamycin. | 2017 Aug |
1 |
| 5 |
27686967 | Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. | 2016 Dec |
2 |
| 6 |
25813876 | Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling. | 2015 Jul |
2 |
| 7 |
25875045 | Involvement of mTOR in Type 2 CRF Receptor Inhibition of Insulin Signaling in Muscle Cells. | 2015 Jun |
1 |
| 8 |
24936056 | The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT. | 2014 Aug 1 |
1 |
| 9 |
22890326 | The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling. | 2013 Jul 4 |
1 |
| 10 |
21701901 | Murine gamma herpes virus 68 infection promotes fatty liver formation and hepatic insulin resistance in C57BL/6J mice. | 2012 Apr |
2 |
| 11 |
22028412 | Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation. | 2012 Jan 15 |
1 |
| 12 |
22281494 | Improved insulin sensitivity by rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes. | 2012 Feb 10 |
1 |
| 13 |
20936651 | Comparison of intracellular signalling by insulin and the hypermitogenic AspB10 analogue in MCF-7 breast adenocarcinoma cells. | 2011 May |
1 |
| 14 |
21478152 | Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways. | 2011 May 27 |
1 |
| 15 |
21602475 | Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake. | 2011 Aug |
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| 16 |
19887566 | Central insulin signaling is attenuated by long-term insulin exposure via insulin receptor substrate-1 serine phosphorylation, proteasomal degradation, and lysosomal insulin receptor degradation. | 2010 Jan |
2 |
| 17 |
20135346 | Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. | 2010 Aug |
1 |
| 18 |
19356713 | A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. | 2009 Apr |
1 |
| 19 |
18264722 | Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts. | 2008 Aug |
1 |
| 20 |
18922904 | Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. | 2008 Oct 15 |
1 |
| 21 |
17329620 | The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man. | 2007 Jun |
1 |
| 22 |
17334390 | Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. | 2007 Aug 16 |
1 |
| 23 |
17908691 | Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling. | 2007 Dec 7 |
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| 24 |
16452206 | mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. | 2006 Feb 1 |
1 |
| 25 |
15576463 | Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. | 2005 Mar |
2 |
| 26 |
15988698 | Pharmacological inhibition of p38 MAP kinase results in improved glucose uptake in insulin-resistant 3T3-L1 adipocytes. | 2005 Jul |
1 |
| 27 |
16099428 | Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1. | 2005 Sep 30 |
1 |
| 28 |
16129690 | Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. | 2005 Oct 14 |
1 |
| 29 |
16227402 | Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade. | 2005 Oct |
3 |
| 30 |
11948686 | Role of mTOR in the degradation of IRS-1: regulation of PP2A activity. | 2002 |
1 |
| 31 |
12051762 | Rapamycin partially prevents insulin resistance induced by chronic insulin treatment. | 2002 May 10 |
1 |
| 32 |
11147790 | Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation. | 2001 Jan |
3 |
| 33 |
11287630 | A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. | 2001 Apr 10 |
1 |
| 34 |
11438661 | Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. | 2001 Aug |
4 |
| 35 |
10847581 | A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. | 2000 Jun |
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