Glutamic Acid

microtubule associated protein tau ; Homo sapiens







38 Article(s)
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1 34591222 Network activity changes in the pathophysiology of Alzheimer's disease: the role of aging and early entorhinal cortex dysfunction. 2022 Feb 1
2 35038671 1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults. 2022 Apr 3
3 35274343 Extracellular tau oligomers affect extracellular glutamate handling by astrocytes through downregulation of GLT-1 expression and impairment of NKA1A2 function. 2022 Mar 10 2
4 35358667 Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation. 2022 Jul 1
5 33075193 Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. 2021 Jan 1
6 33246331 Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. 2021 Feb 12 1
7 33303219 Genetic variants in glutamate-, Aβ-, and tau-related pathways determine polygenic risk for Alzheimer's disease. 2021 May 1
8 33616735 High performance liquid chromatography determination of L-glutamate, L-glutamine and glycine content in brain, cerebrospinal fluid and blood serum of patients affected by Alzheimer's disease. 2021 Mar 1
9 34416145 Modeling neurodegeneration with mutant-tau organoids. 2021 Aug 19 2
10 34469725 Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau. 2021 Aug 31 2
11 34769068 Differential Effects of Human P301L Tau Expression in Young versus Aged Mice. 2021 Oct 28 1
12 34786841 Hypothesis: Modulation of microglial phenotype in Alzheimer's disease drives neurodegeneration. 2021 Nov 17 1
13 31774919 Astroglial contribution to tau-dependent neurodegeneration. 2019 Nov 29 1
14 31904014 Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes. 2019 Dec 20 1
15 32096031 Presynaptic Pathophysiology Encoded in Different Domains of Tau - Hyper-Versus Hypoexcitability? 2019 1
16 30251689 cPLA2 and desaturases underlie the tau hyperphosphorylation offset induced by BACE knock-down in neuronal primary cultures. 2018 Nov 1
17 26931569 The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity. 2016 Apr 1
18 26971324 Dysfunction of NMDA receptors in Alzheimer's disease. 2016 Jul 1
19 27721502 Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. 2016 Oct 10 1
20 26070304 Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. 2015 Dec 2
21 24534188 Neuronal activity regulates extracellular tau in vivo. 2014 Mar 10 1
22 21919991 Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease. 2012 Mar 1
23 22334661 Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). 2012 Mar 30 3
24 21910444 Structural impact of proline-directed pseudophosphorylation at AT8, AT100, and PHF1 epitopes on 441-residue tau. 2011 Oct 12 1
25 22002427 Truncation of tau at E391 promotes early pathologic changes in transgenic mice. 2011 Nov 1
26 19642195 Deletion of tau attenuates heat shock-induced injury in cultured cortical neurons. 2010 Jan 1
27 18467332 Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases. 2008 Jun 27 1
28 18725412 Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation. 2008 Nov 14 1
29 16407562 Impaired glutamate transport in a mouse model of tau pathology in astrocytes. 2006 Jan 11 1
30 12769185 Lysosomal activation is a compensatory response against protein accumulation and associated synaptopathogenesis--an approach for slowing Alzheimer disease? 2003 May 1
31 14627651 Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes. 2003 Nov 19 1
32 10961425 Markers of apoptosis and models of programmed cell death in Alzheimer's disease. 2000 1
33 10461542 Damage and repair of nerve cell DNA in toxic stress. 1999 Aug 2
34 10461544 Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions. 1999 Aug 5
35 9427355 Co-localization of truncated tau and DNA fragmentation in Alzheimer's disease neurones. 1997 Dec 1 2
36 8781663 Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's disease. 1996 2
37 1351785 A dose-dependent increase of Tau immunostaining is produced by glutamate toxicity in primary neuronal cultures. 1992 Feb 14 2
38 3099793 Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease. 1986 Dec 15 1