quizartinib

fms related receptor tyrosine kinase 3 ; Homo sapiens







111 Article(s)
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101 23714533 The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. 2013 4
102 23967177 The FLT3 inhibitor quizartinib inhibits ABCG2 at pharmacologically relevant concentrations, with implications for both chemosensitization and adverse drug interactions. 2013 5
103 23998902 The E3 ubiquitin ligase TRAF2 can contribute to TNF-α resistance in FLT3-ITD-positive AML cells. 2013 Nov 2
104 24002496 Phase I study of quizartinib administered daily to patients with relapsed or refractory acute myeloid leukemia irrespective of FMS-like tyrosine kinase 3-internal tandem duplication status. 2013 Oct 10 2
105 24070241 The role of quizartinib in the treatment of acute myeloid leukemia. 2013 Dec 5
106 22504184 Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 2012 Apr 15 3
107 22875611 The N676D and G697R mutations in the kinase domain of FLT3 confer resistance to the inhibitor AC220. 2012 Nov 1
108 23012328 Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML. 2012 Nov 15 3
109 21895538 The clinical development of FLT3 inhibitors in acute myeloid leukemia. 2011 Oct 2
110 19654408 AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). 2009 Oct 1 1
111 19754199 Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor. 2009 Dec 10 2