| 1 |
34949833 | The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis. | 2022 Feb |
1 |
| 2 |
35159680 | Safety Profile of Rapamycin Perfluorocarbon Nanoparticles for Preventing Cisplatin-Induced Kidney Injury. | 2022 Jan 21 |
1 |
| 3 |
35316218 | Rapamycin limits CD4+ T cell proliferation in simian immunodeficiency virus-infected rhesus macaques on antiretroviral therapy. | 2022 May 16 |
1 |
| 4 |
31074719 | Sirolimus selectively increases circulating Treg cell numbers and restores the Th17/Treg balance in rheumatoid arthritis patients with low disease activity or in DAS28 remission who previously received conventional disease-modifying anti-rheumatic drugs. | 2020 Jan-Feb |
2 |
| 5 |
31876121 | CD4+ T Cells as Key Players in the Immunopathology of Takayasu Arteritis: Comment on the Article by. | 2020 Apr |
1 |
| 6 |
32381646 | Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice. | 2020 Aug |
2 |
| 7 |
32488108 | mTOR-Myc axis drives acinar-to-dendritic cell transition and the CD4+ T cell immune response in acute pancreatitis. | 2020 Jun 2 |
1 |
| 8 |
32535334 | Low expressions of PD-L1 and CTLA-4 by induced CD4+CD25+ Foxp3+ Tregs in patients with SLE and their correlation with the disease activity. | 2020 Sep |
2 |
| 9 |
33329581 | Enhanced Fatty Acid Synthesis Leads to Subset Imbalance and IFN-γ Overproduction in T Helper 1 Cells. | 2020 |
1 |
| 10 |
31191530 | Comprehensive Characterization of a Next-Generation Antiviral T-Cell Product and Feasibility for Application in Immunosuppressed Transplant Patients. | 2019 |
2 |
| 11 |
31624262 | Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation. | 2019 Oct 17 |
1 |
| 12 |
29551338 | Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial. | 2018 Mar 24 |
3 |
| 13 |
30061014 | mTOR pathway activation in large vessel vasculitis. | 2018 Nov |
3 |
| 14 |
27974559 | mTOR Promotes Antiviral Humoral Immunity by Differentially Regulating CD4 Helper T Cell and B Cell Responses. | 2017 Feb 15 |
1 |
| 15 |
26758248 | Human regulatory T cells suppress proliferation of B lymphoma cells. | 2016 Aug |
2 |
| 16 |
26886923 | Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate. | 2016 |
1 |
| 17 |
27400793 | Autophagy Improves the Immunosuppression of CD4+ T Cells by Mesenchymal Stem Cells Through Transforming Growth Factor-β1. | 2016 Nov |
1 |
| 18 |
27569951 | Correlation Between Immunosuppressive Therapy and CD4(+) T-Cell Intracellular Adenosine Triphosphate Levels in Liver Transplant Recipients. | 2016 Jul-Aug |
2 |
| 19 |
25354238 | Cellular and molecular immune profiles in renal transplant recipients after conversion from tacrolimus to sirolimus. | 2015 Apr |
1 |
| 20 |
25682989 | Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells. | 2015 Jun |
1 |
| 21 |
26037126 | Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria. | 2015 Jun 2 |
1 |
| 22 |
24107844 | Rapamycin induces ILT3(high)ILT4(high) dendritic cells promoting a new immunoregulatory pathway. | 2014 Apr |
1 |
| 23 |
24683191 | Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus. | 2014 May 1 |
2 |
| 24 |
23165214 | Sirolimus-based regimen promotes inhibitory costimulatory signal of HVEM/BTLA/CD160/LIGHT pathway in allo-renal recipients. | 2013 Jan |
2 |
| 25 |
23426943 | Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation. | 2013 Apr 11 |
1 |
| 26 |
23835553 | Rapamycin and omega-1: mTOR-dependent and -independent Th2 skewing by human dendritic cells. | 2013 Aug |
1 |
| 27 |
23913957 | Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus. | 2013 Sep 1 |
1 |
| 28 |
23968562 | Rapamycin has suppressive and stimulatory effects on human plasmacytoid dendritic cell functions. | 2013 Dec |
3 |
| 29 |
24123683 | Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo. | 2013 Nov 15 |
2 |
| 30 |
22300641 | Regulatory T cells exhibit decreased proliferation but enhanced suppression after pulsing with sirolimus. | 2012 Jun |
1 |
| 31 |
22366291 | Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates. | 2012 Apr |
3 |
| 32 |
22500984 | Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo. | 2012 Aug |
1 |
| 33 |
22689677 | A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation. | 2012 Dec |
1 |
| 34 |
21094689 | Adoptive transfer of CD4+CD25+ regulatory cells combined with low-dose sirolimus and anti-thymocyte globulin delays acute rejection of renal allografts in Cynomolgus monkeys. | 2011 May |
1 |
| 35 |
21107839 | Expansion of CD4(+)CD25 (+) regulatory T cells from cord blood CD4(+) cells using the common γ-chain cytokines (IL-2 and IL-15) and rapamycin. | 2011 Jun |
2 |
| 36 |
21439133 | Rapamycin generates graft-homing murine suppressor CD8(+) T cells that confer donor-specific graft protection. | 2011 |
4 |
| 37 |
21530600 | CD4(+)CD25(high)CD127(low) regulatory T cells in patients with stable angina and their dynamics after intracoronary sirolimus-eluting stent implantation. | 2011 Jul |
1 |
| 38 |
21538345 | Subsets of human CD4(+) regulatory T cells express the peripheral homing receptor CXCR3. | 2011 Aug |
1 |
| 39 |
21565906 | Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells. | 2011 Sep |
1 |
| 40 |
19903662 | Rapamycin, unlike cyclosporine A, enhances suppressive functions of in vitro-induced CD4+CD25+ Tregs. | 2010 Mar |
4 |
| 41 |
20406686 | Preferential increase in memory and regulatory subsets during T-lymphocyte immune reconstitution after Thymoglobulin induction therapy with maintenance sirolimus vs cyclosporine. | 2010 May |
3 |
| 42 |
20626386 | Rapamycin-conditioned donor dendritic cells differentiate CD4CD25Foxp3 T cells in vitro with TGF-beta1 for islet transplantation. | 2010 Aug |
1 |
| 43 |
18841360 | Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2. | 2009 Jun |
5 |
| 44 |
19453998 | Monotherapy rapamycin allows an increase of CD4 CD25 FoxP3 T cells in renal recipients. | 2009 Sep |
1 |
| 45 |
19715817 | Rapamycin--rather than FK506--might promote allograft tolerance induced by CD4+CD25+ regulatory T cells. | 2009 Sep |
1 |
| 46 |
20137731 | [The effect of the different immunosuppression therapy on CD4(+)Foxp3(+) Treg cells in kidney recipients]. | 2009 Nov 15 |
2 |
| 47 |
18313267 | Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells. | 2008 Jun |
1 |
| 48 |
18424697 | Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin. | 2008 May 1 |
1 |
| 49 |
18559659 | Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells. | 2008 Sep |
3 |
| 50 |
17182569 | Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin. | 2007 Jan 1 |
4 |